MyMD Pharmaceuticals, Inc. announced new data demonstrating Supera-CBD’s superior potency over CBD by factor of 8,000 times. Supera-CBD is MyMD’s pre-clinical patented synthetic cannabidiol (CBD) derivative that is being developed as a pharmaceutical drug to address anxiety, pain, and neurodegeneration. The study was conducted by Eurofins Discovery, a Eurofins Scientific (EUFI.PA) company. Supera-CBD targets the cannabinoid receptor type 2 (CB2), a protein mainly expressed in the immune system and which is associated with the therapeutic effects of CBD, including its anxiolytic, anticonvulsant, antipsychotic, neuroprotective and anti-inflammatory properties. CB2 receptors do not create an intoxicating negative psychotropic reaction (e.g. a high). In contrast, CB1 is usually expressed in the brain and distributed throughout the central nervous system to deliver an intoxicating effect. A vast majority of CBD developers are pursuing compounds targeted to CB2 that have minimal CB1 affinity. In comparison to Supera-CBD, the synthetic cannabinoid CP 55940, another highly potent activator of CB2, is also a highly potent activator of CB1, delivering an intoxicating effect to the user. For this reason, the compound was abandoned by its developer and never marketed. Supera-CBD is estimated by MyMD to be between 40 to 500 times the potency of the first discovered and best-characterized endocannabinoids anandamide and 2-arachidonoyl glycerol, which are produced naturally inside the body. Plant-derived CBD has almost no activity at the CB2 receptor, and therefore has nearly zero potency as a medicinal drug.