Nanoform Finland Plc and Nacuity Pharmaceuticals announced that they have signed a Technology Proof of Concept Agreement, with compensation on standard commercial terms. This will apply Nanoform's award-winning nanoparticle CESS technology to enhance ophthalmic drug delivery of Nacuity's NPI-001 and NPI-002 drug candidates. This work will explore the feasibility of the patented CESS process ("Controlled Expansion of Supercritical Solutions") to produce nanoparticles of both molecules in an effort to enhance ophthalmic drug delivery. Nacuity focuses on ophthalmology and leverages their diverse library of novel antioxidant molecules to address ocular diseases involving oxidative stress. Such stress has been implicated in a variety of ophthalmological conditions and diseases, such as retinitis pigmentosa (including Usher syndrome) cataract, cystinosis, age-related macular degeneration, corneal endothelial cell loss, diabetic retinopathy, glaucoma and presbyopia. Many pharma and biotech companies struggle to realize the full therapeutic potential of their drug candidates stymied by physico-chemical limitations, solubility and bioavailability challenges. Active pharmaceutical ingredients converted to nanometer-sized particles using the CESS process may exhibit greater dissolution rate and intrinsic solubility and offer the potential to enhance penetration into tissues. This presents a unique opportunity to explore how nanoformed particles may enhance the performance of Nacuity's proprietary ophthalmic drug product candidate formulations, inserts and implants.