Next Science : Investor Presentation - Q1 2022

Quarter ended 31 March 2022 Investor Presentation

28 April 2022

Approved by the Board of Next Science

*This presentation contains graphical images

Disclaimer

This presentation has been prepared by Next Science Limited (Company) and is provided for general information purposes only. It is not a product disclosure statement, pathfinder document or any other disclosure document for the purposes of the Corporations Act 2001 (Cth) and has not been, and is not required to be, lodged with the Australian Securities and Investments Commission (ASIC). It should not be relied upon by the recipient in considering the merits of the Company or the acquisition of shares in the Company. This presentation should not be considered an offer or an invitation to acquire or sell, or a solicitation to invest in or refrain from investing in, new shares in the Company or any other financial products.

This document has been prepared based on information available as at the date of this presentation. It contains selected summary information and does not purport to be all-inclusive, comprehensive or to contain all of the information that may be relevant or which a prospective investor may require in evaluations for a possible investment in the Company. It should be read in conjunction with the Company's periodic and continuous disclosure announcements which are available atwww.nextscience.com and www.asx.com.au. The recipient acknowledges that circumstances may change and that this presentation may become outdated as a result. This presentation and the information in it are subject to change without notice. The Company is not obliged to update this presentation.

The information contained in this presentation does not constitute investment, legal, tax, accounting or financial product advice nor any recommendation to acquire securities in the Company. This presentation has been prepared without taking account of any person's individual investment objectives, financial situation or particular needs. Before making an investment decision, the recipient should consider its own financial situation, objectives and needs, and conduct its own independent investigation and assessment of the contents of this presentation, including obtaining investment, legal, tax, accounting and such other advice as it considers necessary or appropriate. Any references to or explanations of legislation, regulatory issues, benefits or any other legal commentary (if any) are indicative only, do not summarise all relevant issues and are not intended to be a full explanation of a particular matter. The information in this presentation has been obtained from and based on sources believed by the Company to be reliable. Past performance is not an indication of future performance.

This presentation may contain forward-looking statements, guidance, forecasts, estimates, prospects, projections or statements in relation to future matters that may involve risks or uncertainties and may involve significant items of subjective judgement and assumptions of future events that may or may not eventuate (Forward Statements). Forward Statements can generally be identified by the use of forward looking words such as "anticipate", "estimates", "will", "should", "could", "may", "expects", "plans", "forecast", "target" or similar expressions. Forward Statements including indications, guidance or outlook on future revenues, distributions or financial position and performance or return or growth in underlying investments are provided as a general guide only and should not be relied upon as an indication or guarantee of future performance. No independent third party has reviewed the reasonableness of any such statements or assumptions. None of the Company, its related bodies corporate and their respective officers, directors, employees, advisers, partners, affiliates and agents (together, the Next Science Parties) represent or warrant that such Forward Statements will be achieved or will prove to be correct or gives any warranty, express or implied, as to the accuracy, completeness, likelihood of achievement or reasonableness of any Forward Statement contained in this presentation. Except as required by law or regulation, the Company assumes no obligation to release updates or revisions to Forward Statements to reflect any changes. Recipients should form their own views as to these matters and any assumptions on which any of the Forward Statements are based and not place reliance on such statements.

All dollar values are in $USD unless stated otherwise.

An investment in Company shares is subject to investment and other known and unknown risks, some of which are beyond the control of the Company, including factors and risks specific to the industry in which Next Science operates as well as general economic conditions, prevailing exchange rates and interest rates and conditions in the financial markets. The Company does not guarantee any particular rate of return on its performance nor does it guarantee any particular tax treatment. Prospective investors should make their own enquiries and investigations regarding all information in this presentation, including the assumptions, uncertainties and contingencies which may affect future operations of the Company and the impact that different future outcomes may have on the Company.

The distribution of this presentation to persons or in jurisdictions outside Australia may be restricted by law and any person into whose possession this document comes should seek advice on and observe those restrictions. Any failure to comply with such restrictions may violate applicable securities law.

No party other than the Company has authorised, permitted or caused the issue, submission, dispatch or provision of this presentation, or takes any responsibility for, or makes or purports to make any statement, representation or undertaking in this presentation and there is no statement in this presentation that is based on any statement by any other party. No person, either as a director or partner of, or in the employment of, the Company has any authority to make, imply, or give any representation or warranty whatsoever in relation to the information contained in this presentation. None of the Next Science Parties take any responsibility for any information in this presentation or any action taken by you on the basis of such information. To the maximum extent permitted by law, the Next Science Parties: exclude and disclaim all liability, including (without limitation) any liability for fraud or negligence, for any expenses, losses, damages or costs incurred either as a result of the information in this presentation being inaccurate or incomplete in any way for any reason, or otherwise arising in connection with this presentation; and make no representation or warranty, express or implied, as to the currency, accuracy, reliability or completeness of information in this presentation.

Q1 2022 Highlights - accelerating market awareness and adoption

• • Product sales growth in Q1 2022, 31% increase on pcp

• • Resolution of Zimmer dispute. Zimmer sales management engaged and focused on XPERIENCETM launch in H2 2022 in the US

• • TELA Bio Inc launch of Site GuardTM (White label - XPERIENCETM) in US in Q1 2022 with their sales force driving early wins

• • Contracted dedicated distributor for XPERIENCETM for New Zealand. Product sales commencing in Q2 2022

Increased US XPERIENCETMTM customer base to 119 Hospitals (+42% on Q4) and 210 Surgeons

(+31% on Q4)

Next Science to train Zimmer sales representatives for the H2 2022

Zimmer XPERIENCETM launch

First clinical XPERIENCETM case study results to be published June/July. Results show over 900 hip & knee replacements with zero infection.

Next Science's Xbio product platform - US$22B total addressable market

Treating chronic wounds:

Preventing surgical site infection (SSI)1:

8.2 million patients in the US1 Total addressable market $11BChronic wounds can be a cause of death in 27.7% of patients within a 2 year period.2

Total market 110 million surgical procedures pa1 2 million SSIs occurring per year in the US1 SSI causes 90,000 deaths pa

Total addressable market $11B

Cost to US healthcare system to treat >$50B pa 2

Approved products are reimbursed by CMS (Medicare/Medicaid) and main insurers

NXS 2022 focus:

• • Veterans Affairs' hospitals (171 medical centres and 1,121 outpatient clinics)

• • Chronic wound clinics in commercial hospitals

• • (>1000 Centres)

• • Private Podiatry offices (DFUs) (>10,382 offices)Cost to US healthcare system to treat $25-40B pa1, increased 36% in the past decade1

Preventative technologies covered in 'Episode of Care' costs paid by insurance companies or by

CMS (Medicare/Medicaid)

NXS current focus:

• • >7M orthopaedic procedures pa

• • >1.2M plastic surgeries pa

FY22 growth continuing

• • YTD 2022 XPERIENCETM adoption has increased to 210 surgeons (~1% of US orthopaedic surgeons*) in 119 US hospitals

• • Additional system accounts include Advent Health (34 hospitals predominantly based in Florida) UNC Health (7 hospitals based in Carolinas). These are outcomes of the commercial strategy focus on "land and expand" - add new hospitals and grow pull-through of new surgeons

• • Distribution through Zimmer's exclusive hip & knee field force of sales agents to provide increased access to the US orthopaedic markets

XP US Hospitals and Surgeons

250

200

150

100

50

0

Q2 2021

Q3 2021

Q4 2021

Q1 2022

Hospitals

Surgeons