Novo Nordisk A/S: Trading in Novo Nordisk shares by board members, executives and associated persons

Bagsværd, Denmark, 3 May 2022 — This document discloses the data of the transaction(s) made in Novo Nordisk shares by the company’s board members, executives and their associated persons in accordance with Article 19 of Regulation No. 596/2014 on market abuse.

The company’s board members, executives and their associated persons have given Novo Nordisk power of attorney on their behalf to publish trading in Novo Nordisk shares by the company’s board members, executives and their associated persons.

Please find below a statement of such trading in shares issued by Novo Nordisk.

1	Details of the person discharging managerial responsibilities/person closely associated
a)	Name of the Board member/Executive/Associated Person	Doug Langa
2	Reason for the notification
a)	Position/status	Executive Vice President, North America Operations
b)	Initial notification/Amendment	Initial notification
3	Details of the issuer
a)	Name	Novo Nordisk A/S
b)	LEI	549300DAQ1CVT6CXN342
4	Details of the transaction(s)
a)	Description of the financial instrument, type of instrument,	Shares
	Identification code	Novo Nordisk B DK0060534915
b)	Nature of the transaction	Sale of shares
c)	Price(s) and volume(s)		Price(s)	Volume(s)
			DKK 808,10	200 Shares
			DKK 808,10	204 Shares
			DKK 807,90	29 Shares
			DKK 807,70	110 Shares
			DKK 807,90	2 Shares
			DKK 807,90	24 Shares
			DKK 807,90	95 Shares
			DKK 807,90	85 Shares
			DKK 807,90	70 Shares
			DKK 807,60	170 Shares
			DKK 807,50	179 Shares
			DKK 807,05	200 Shares
			DKK 807,10	185 Shares
			DKK 807,05	185 Shares
			DKK 807,10	93 Shares
			DKK 807,40	62 Shares
			DKK 807,40	27 Shares
			DKK 807,50	15 Shares
			DKK 807,50	15 Shares
			DKK 807,50	14 Shares
			DKK 807,50	169 Shares
			DKK 807,60	217 Shares
			DKK 807,60	115 Shares
			DKK 807,50	23 Shares
			DKK 807,80	494 Shares
			DKK 807,80	27 Shares
			DKK 807,70	495 Shares
			DKK 807,80	4913 Shares
			DKK 807,60	38 Shares
			DKK 807,50	54 Shares
			DKK 807,60	8 Shares
			DKK 807,60	5 Shares
			DKK 807,60	85 Shares
			DKK 807,50	125 Shares
			DKK 807,45	230 Shares
			DKK 807,60	44 Shares
			DKK 807,60	22 Shares
			DKK 807,60	104 Shares
			DKK 807,55	870 Shares
			DKK 807,70	69 Shares
			DKK 807,70	46 Shares
			DKK 808,00	38 Shares
			DKK 808,00	20 Shares
			DKK 808,00	44 Shares
			DKK 808,00	87 Shares
			DKK 808,30	10 Shares
			DKK 808,30	17 Shares
			DKK 808,30	10 Shares
			DKK 808,30	8 Shares
			DKK 808,30	62 Shares
			DKK 808,30	13 Shares
			DKK 808,40	27 Shares
			DKK 808,40	62 Shares
			DKK 808,50	27 Shares
			DKK 808,50	62 Shares
			DKK 808,60	24 Shares
			DKK 808,60	3 Shares
			DKK 808,60	12 Shares
			DKK 808,60	62 Shares
			DKK 808,60	12 Shares
			DKK 808,70	27 Shares
			DKK 808,70	62 Shares
			DKK 808,90	27 Shares
		DKK 808,90	62 Shares
		DKK 808,90	27 Shares
		DKK 808,90	43 Shares
		DKK 808,90	19 Shares
		DKK 808,70	1 Shares
		DKK 808,60	15 Shares
d)	Aggregated information Aggregated volume Price	11,000 shares DKK 807.76
e)	Date of the transaction	2022-04-29
f)	Place of the transaction	Nasdaq Copenhagen

1	Details of the person discharging managerial responsibilities/person closely associated
a)	Name of the Board member/Executive/Associated Person	Henrik Ehlers Wulff
2	Reason for the notification
a)	Position/status	Executive Vice President, Product Supply, Quality and IT
b)	Initial notification/Amendment	Initial notification
3	Details of the issuer
a)	Name	Novo Nordisk A/S
b)	LEI	549300DAQ1CVT6CXN342
4	Details of the transaction(s)
a)	Description of the financial instrument, type of instrument,	Shares
	Identification code	Novo Nordisk B DK0060534915
b)	Nature of the transaction	Sale of shares
c)	Price(s) and volume(s)
			Price(s)	Volume(s)
			DKK 815.00	6,346 shares
d)	Aggregated information Aggregated volume Price	6,346 shares DKK 815.00
e)	Date of the transaction	2022-05-02
f)	Place of the transaction	Nasdaq Copenhagen

1	Details of the person discharging managerial responsibilities/person closely associated
a)	Name of the Board member/Executive/Associated Person	Henrik Ehlers Wulff
2	Reason for the notification
a)	Position/status	Executive Vice President, Product Supply, Quality and IT
b)	Initial notification/Amendment	Initial notification
3	Details of the issuer
a)	Name	Novo Nordisk A/S
b)	LEI	549300DAQ1CVT6CXN342
4	Details of the transaction(s)
a)	Description of the financial instrument, type of instrument,	Shares
	Identification code	Novo Nordisk B DK0060534915
b)	Nature of the transaction	Sale of shares
c)	Price(s) and volume(s)
			Price(s)	Volume(s)
			DKK 814.00	10,954 shares
d)	Aggregated information Aggregated volume Price	10,954 shares DKK 814.00
e)	Date of the transaction	2022-05-03
f)	Place of the transaction	Nasdaq Copenhagen

Novo Nordisk is a leading global healthcare company, founded in 1923 and headquartered in Denmark. Our purpose is to drive change to defeat diabetes and other serious chronic diseases such as obesity and rare blood and endocrine disorders. We do so by pioneering scientific breakthroughs, expanding access to our medicines, and working to prevent and ultimately cure disease. Novo Nordisk employs about 49,300 people in 80 countries and markets its products in around 170 countries. Novo Nordisk's B shares are listed on Nasdaq Copenhagen (Novo-B). Its ADRs are listed on the New York Stock Exchange (NVO). For more information, visit novonordisk.com,Facebook, Twitter, LinkedIn, andYouTube.

Further information

Media:
Ambre Brown Morley	[phone]	[e-mail]
Natalia Salomao Abrahao (US)	[phone]	[e-mail]
Investors:
Daniel Muusmann Bohsen	[phone]	[e-mail]
Ann Søndermølle Rendbæk	[phone]	[e-mail]
David Heiberg Landsted	[phone]	[e-mail]
Jacob Martin Wiborg Rode	[phone]	[e-mail]
Mark Joseph Root (US)	[phone]	[e-mail]

Company announcement No 39 / 2022

Attachment

• CA220503_ InsiderTrading