Item 1.01 Entry into a Material Definitive Agreement

On February 23, 2021, Odonate Therapeutics, Inc. (the "Company") entered into an Open Market Sale AgreementSM (the "Sale Agreement") with Jefferies LLC (the "Agent"), pursuant to which the Company may offer and sell shares of the Company's common stock having an aggregate offering price of up to $100,000,000, from time to time, in "at the market" offerings through the Agent. Sales of the shares of common stock, if any, will be made at prevailing market prices at the time of sale, or as otherwise agreed with the Agent. The Agent will receive a commission from the Company of 3.0% of the gross proceeds of any shares of common stock sold under the Sale Agreement.

The Company is not obligated to sell, and the Agent is not obligated to buy or sell, any shares of common stock under the Sale Agreement. No assurance can be given that the Company will sell any shares of common stock under the Sale Agreement, or, if it does, as to the price or amount of shares of common stock that it sells or the dates when such sales will take place.

In the Sale Agreement, the Company agreed to indemnify the Agent against certain liabilities, including under the Securities Act of 1933, as amended, or to contribute payments that the Agent may be required to make because of such liabilities.

The shares of common stock sold pursuant to the Sale Agreement will be offered pursuant to a shelf registration statement on Form S-3 (File No. 333­233990), which became effective on October 18, 2019. The Company filed a prospectus supplement with the U.S. Securities and Exchange Commission on February 23, 2021 in connection with the offer and sale of shares of the Company's common stock pursuant to the Sale Agreement.

A copy of the Sale Agreement is attached as Exhibit 1.1 hereto and is incorporated herein by reference. The foregoing description of the Sale Agreement does not purport to be complete and is qualified in its entirety by reference to the full text of the Sale Agreement.

A copy of the opinion of Gibson, Dunn & Crutcher LLP relating to the validity of the shares of common stock that may be sold pursuant to the Sale Agreement is filed herewith as Exhibit 5.1.

Item 9.01 Financial Statements and Exhibits



(d) Exhibits



Exhibit
  No.                                     Description

 1.1        Odonate Therapeutics, Inc. Open Market Sale Agreement

 5.1        Opinion of Gibson, Dunn & Crutcher LLP

23.1        Consent of Gibson, Dunn & Crutcher LLP (included in Exhibit 5.1)

104       Cover Page Interactive Data File (embedded within the Inline XBRL document)

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