Osaka, Japan - Ono Pharmaceutical Co., Ltd. (President and CEO, Gyo Sagara; 'the Company') announced that it has acquired its own shares pursuant to the provision of Article 156 of the Companies Act, applied by replacing terms pursuant to the provision of Paragraph 3, Article 165 of the same Act. The status of the acquisition (progress report) is as follows:

1. Class of shares acquired

Common stock of the Company

2. Total number of shares acquired

334,400 shares

3. Total amount of acquisition cost

849,835,900 yen

4. Period of acquisition

November 29 to 30, 2021 (execution base)

5. Method for acquisition

Purchased on the Tokyo Stock Exchange

(Reference)

1. Details of the resolution on November 26, 2021 by documents instead of resolution by board meetings

1. Class of shares to be acquired

Common stock of the Company

2. Total number of shares acquired

11 million shares (maximum)

(2.20% of the total outstanding shares excluding own shares)

3. Total amount of acquisition cost

30.0 billion yen (maximum)

4. Period of acquisition

November 29, 2021 to April 28, 2022

2. Accumulated Company's own shares acquired through November 30, 2021, pursuant to the resolution by documents instead of resolution by board meetings

1. Total number of shares acquired?

334,400 shares

2. Total amount of acquisition cost

849,835,900 yen

Contact:

ONO PHARMACEUTICAL CO., LTD.

Corporate Communications

Mail: public_relations@ono.co.jp

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