Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

On December 5, 2022, Michele Janis informed OptiNose, Inc. (the "Company) of her resignation as the Company's Acting Chief Financial Officer to accept a Chief Financial Officer role at a privately-held company, which resignation will become effective on December 30, 2022.

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