Oragenics, Inc. announced favorable preliminary results from its ongoing Good Laboratory Practice (GLP) toxicology study to evaluate the safety profile and immunogenicity of its NT-CoV2-1 vaccine candidate in rabbits. These initial results continue to demonstrate a safety profile and immune responses that the Company believes will support regulatory filings required to progress to a Phase 1 clinical study. The final toxicology report, including ongoing histopathology evaluation, is expected by year-end.

The objectives of this ongoing toxicology study are to evaluate the potential toxicity of NT-CoV2-1 following repeated intranasal administration at the maximal dose anticipated to be used in humans, and to confirm the immunogenicity of the vaccine.