Patrys Limited announced it has completed initial production and characterisation of PAT-DX3, a full-sized, humanised antibody version of its dimerised antibody fragment PAT-DX1. This full-sized version is likely to have different pharmaceutical properties (pharmacokinetics, half-life and tissue distribution) to PAT-DX1 that may provide opportunities to use it for additional clinical applications. Patrys' lead asset, PAT-DX1 is an engineered version of the mouse lupus antibody 3E10, which has been miniaturised to just contain two copies of the binding domain of 3E10, and further modified to improve its binding properties. PAT-DX1 has been shown to cross the blood brain barrier (BBB), reduce tumour size, and increase survival in multiple animal models of brain cancer, other cancers, and cancer metastases. PAT-DX1 is tumour-agnostic, meaning that it can target many different tumour types in the body, regardless of specific tumour antigens. Initial development and characterisation of PAT-DX3 has confirmed that, like PAT-DX1, it penetrates into cancer cell nuclei and binds to the DNA released from solid tumours. Based on these findings, Patrys expects that PAT-DX3 is likely to show similar efficacy benefits in animal models of cancer. The company intends to undertake testing in these models following pharmacokinetic (PK) studies run in parallel with ongoing PK studies for PAT-DX1. Having both a dimerised antibody fragment (PAT-DX1) and a full-sized, humanised antibody (PAT-DX3) available will provide Patrys with a range of options to exploit the unique characteristics of this antibody for human therapeutic applications. Patrys' existing patent grants and applications cover the use PAT-DX3 as well as PAT-DX1, with patents granted in Europe, Japan, China and the USA. Patrys has granted or pending patents in major jurisdictions where future regulatory approvals and product sales are targeted, and currently has more than 19 patent applications pending across 10 different patent families.