Pharming N : Group Notice of 2021 Full Year Results

Pharming Group Notice of 2021 Full Year Results

Leiden, The Netherlands, March 8, 2022: Pharming Group N.V. ("Pharming" or "the Company")

(Euronext Amsterdam: PHARM/Nasdaq: PHAR) confirms it will announce its preliminary (unaudited) financial report for the full year ended December 31, 2021 on Thursday, March 17, 2022.

The Company will host a conference call for analysts and institutional investors at 14:00CET/08:00ET on March 17, 2022. Details for the conference call are below.

In addition, the Company will hold a webinar on Thursday, March 24, 2022 at 19:00CET for its retail shareholder base. During the broadcast, CEO Sijmen de Vries and CFO Jeroen Wakkerman will review the events of 2021 and the recently published financial results. To sign up please visit the Company's website: www.pharming.com

Conference call dial-in information

Thursday, March 17, 2022 14:00CET/08:00ET

Please note, the Company will only take questions from dial-in attendees.

Dial-in details:

Netherlands (Local)	085 888 7233
United Kingdom	0800 640 6441
United Kingdom (Local) 020 3936 2999
United States (Local)	1 646 664 1960
All other locations	[phone]
Access code: 847189

Conference call webcast Link:

https://webcast.openbriefing.com/pharming-fy21/

About Pharming Group N.V.

Pharming Group N.V. is a global, commercial stage biopharmaceutical company developing innovative protein replacement therapies and precision medicines for the treatment of rare diseases and unmet medical needs.

The flagship of our portfolio is our recombinant human C1 esterase inhibitor (rhC1INH) franchise. C1INH is a naturally occurring protein that down regulates the complement and contact cascades in order to control inflammation in affected tissues.

Our lead product, RUCONEST®, is the first and only plasma-free rhC1INH protein replacement therapy. It is approved for the treatment of acute hereditary angioedema (HAE) attacks. We are commercializing RUCONEST® in the United States, the European Union and the United Kingdom through our own sales and marketing organization, and the rest of the world through our distribution network.

In addition, we are investigating the clinical efficacy of rhC1INH in the treatment of further indications, including pre-eclampsia, acute kidney injury and severe pneumonia as a result of COVID-19 infections.

We are also studying our oral precision medicine, leniolisib (a phosphoinositide 3-kinase delta, or PI3K delta, inhibitor), for the treatment of activated PI3K delta syndrome, or APDS. Worldwide rights for leniolisib were licensed from Novartis AG in 2019. Leniolisib met both of its primary end points in a registration enabling Phase 2/3 study in the United States and Europe. We are targeting global regulatory filings for leniolisib from Q2 2022 onwards.

Additionally, we entered into a strategic collaboration with Orchard Therapeutics to research, develop, manufacture and commercialize OTL-105, a newly disclosed investigational ex-vivo autologous hematopoietic stem cell (HSC) gene therapy for the treatment of HAE.

Furthermore, we are leveraging our transgenic manufacturing technology to develop next- generation protein replacement therapies, most notably for Pompe disease, which is currently in preclinical development.

Forward-looking Statements

This press release contains forward-looking statements, including with respect to timing and progress of Pharming's preclinical studies and clinical trials of its product candidates, Pharming's clinical and commercial prospects, Pharming's ability to overcome the challenges posed by the COVID-19 pandemic to the conduct of its business, and Pharming's expectations regarding its projected working capital requirements and cash resources, which statements are subject to a number of risks, uncertainties and assumptions, including, but not limited to the scope, progress and expansion of Pharming's clinical trials and ramifications for the cost thereof; and clinical, scientific, regulatory and technical developments. In light of these risks and uncertainties, and other risks and uncertainties that are described in Pharming's 2020 Annual Report and the Annual Report on Form 20-F for the year ended December 31, 2020 filed with the U.S. Securities and Exchange Commission, the events and circumstances discussed in such forward-looking statements may not occur, and Pharming's actual results could differ materially and adversely from those anticipated or implied thereby. Any forward-looking statements speak only as of the

date of this press release and are based on information available to Pharming as of the date of this release.

Inside Information

This press release relates to the disclosure of information that qualifies, or may have qualified, as inside information within the meaning of Article 7(1) of the EU Market Abuse Regulation.

For further public information, contact:

Pharming Group, Leiden, The Netherlands Sijmen de Vries, CEO: T: [phone]

Susanne Embleton, Investor Relations Manager: T: [phone] E: [e-mail]

FTI Consulting, London, UK

Victoria Foster Mitchell/Alex Shaw

1. [phone] FTI Consulting, USA Jim Polson

1. [phone]

LifeSpring Life Sciences Communication, Amsterdam, The Netherlands

Leon Melens

T: [phone]

E: [e-mail]