Item 5.07. Submission of Matters to a Vote of Security Holders

At the Protagonist Therapeutics, Inc. (the "Company") 2022 Annual Meeting of Stockholders (the "Annual Meeting") held on May 26, 2022, the stockholders voted on the four proposals listed below. The proposals are described in detail in the Company's definitive proxy statement for the Annual Meeting, filed with the Securities and Exchange Commission on April 13, 2022. The results of the matters voted upon at the Annual Meeting were:

Proposal 1 - To elect the two Class III directors named below to serve until the 2025 Annual Meeting of Stockholders. Each of the two named nominees was so elected, with the votes thereon as follows:





                                         Final Voting Results
Nominees                      For           Withheld        Broker Non-Votes
Harold E. Selick, Ph.D.     27,907,944       8,361,194           2,405,334
Bryan Giraudo               28,108,252       8,160,886           2,405,334

Proposal 2 - To approve, on an advisory basis, the compensation of the Company's named executive officers. This proposal was approved by the requisite vote, with the votes thereon as follows:





                     Final Voting Results
    For           Against      Abstain       Broker Non-Votes
  35,832,587       413,371       23,180           2,405,334

Proposal 3 - To recommend, by non-binding vote, the frequency of future executive compensation votes. The votes on this proposal were as follows:





                           Final Voting Results
   1 Year        2 Years       3 Years      Abstain       Broker Non-Votes
  35,578,366        4,924       683,401        2,447           2,405,334

Considering the strong support for an annual vote as reflected in the voting results, the Company intends to hold future advisory votes to approve executive compensation annually until the matter is again submitted to the Company's stockholders for a vote.

Proposal 4 - To ratify the selection of Ernst & Young LLP as the Company's independent registered public accounting firm for the fiscal year ending December 31, 2022. This proposal was approved by the requisite vote, with the votes thereon as follows:





                    Final Voting Results
    For          Against      Abstain       Broker Non-Votes
  38,667,405        5,575        1,492                --

No other matters were submitted for stockholder action.

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