On March 17, 2022, Don Kalkofen, the Chief Financial Officer of Protagonist Therapeutics, Inc. (the “Company”), submitted his notice of resignation from his position as Chief Financial Officer of the Company to be effective on April 1, 2022. Upon his resignation, Mr. Kalkofen will cease to serve as the Company's principal financial and accounting officer. The Company has initiated a search for a replacement for Mr. Kalkofen.