Item 5.02 Departure of Directors or Principal Officers; Election of Directors; Appointment of Principal Officers.

Appointment of Allison Dorval to the Board

On July 8, 2021, Allison Dorval, 45, was appointed to the Board of Directors (the "Board") of Puma Biotechnology, Inc. (the "Company"), effective July 15, 2021. Ms. Dorval will serve on the Board for a term expiring at the 2022 Annual Meeting of Stockholders and until her successor is duly elected and qualified, or until her earlier death, resignation or removal. In connection with her appointment to the Board, Ms. Dorval was also appointed to the Audit Committee of the Board (the "Audit Committee").

Ms. Dorval has served as the Chief Financial Officer of Voyager Therapeutics, Inc. ("Voyager"), a public clinical stage gene therapy company, since November 2018 and as Voyager's principal financial officer and principal accounting officer since June 2018. Ms. Dorval joined Voyager as its Vice President of Finance in June 2017 and is a certified public accountant. Prior to joining Voyager, Ms. Dorval served as Vice President and Controller of Juniper Pharmaceuticals, Inc., a biopharmaceutical company, from August 2016 to June 2017, and as a consultant at Danforth Advisors, a life sciences consultancy focusing on accounting and financial matters, from September 2015 to August 2016. In connection with her role at Danforth, Ms. Dorval served as interim Chief Financial Officer of medical device companies 480 Biomedical, Inc. and Arsenal Medical, Inc. from December 2015 to August 2016. Prior to her time at Danforth, Ms. Dorval served in several roles at Insulet Corporation, a medical device company, from August 2008 to July 2015, including as Chief Financial Officer from November 2014 to May 2015 and as Vice President and Controller from August 2008 to November 2014. Earlier in her career, Ms. Dorval served in various financial and accounting capacities at iBasis, Inc., a telecommunications company; Digitas Inc., an advertising company; and PricewaterhouseCoopers LLP. Ms. Dorval received a B.S. in Business Administration, with a concentration in Accounting, from the University of Vermont and has completed a graduate-level certificate program in Taxation at Bentley University's McCallum Graduate School of Business. Ms. Dorval was selected as a director because of her extensive background in finance and accounting and her experience in the life sciences industry.

Ms. Dorval will receive the standard fees paid by the Company to all of its non-employee directors and members of the Audit Committee under the Company's non-employee director compensation program, a copy of which is filed as Exhibit 10.3 to the Company's Quarterly Report on Form 10-Q filed with the SEC on May 7, 2020 and incorporated herein by reference.

In accordance with the Company's customary practice, the Company is entering into an indemnification agreement with Ms. Dorval, which will require the Company to indemnify her against certain liabilities that may arise as result of her status or service as a director.

There are no arrangements or understandings between Ms. Dorval and any other person pursuant to which she was selected as a director, nor are there any transactions in which Ms. Dorval has an interest that would be reportable under Item 404(a) of Regulation S-K.

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