Item 5.02 Departure of Directors or Certain Officers; Election of Directors;


          Appointment of Certain Officers; Compensatory Arrangements of Certain
          Officers.


On December 9, 2021, Ann Miller notified Puma Biotechnology, Inc. ("Puma" or the "Company") of her decision to resign as a director of the Company, effective December 31, 2021. Dr. Miller's resignation is not the result of any disagreement with the Company.

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