Item 1.01 Entry into a Material Definitive Agreement.

On February 3, 2021, as contemplated by the terms of the amended and restated loan and security agreement, dated June 28, 2019, by and between Puma Biotechnology, Inc. (the "Company") and Oxford Finance LLC ("Oxford"), as collateral agent and lender, as amended February 27, 2020, July 6, 2020 and August 5, 2020 (the "Credit Facility"), the Company and Oxford amended the Credit Facility to amend the Company's minimum revenue thresholds for the trailing year to date periods ending March 31, June 30, September 30 and December 31, 2021 (the "Fourth Amendment"). Other than as set forth in the Fourth Amendment, the terms of the Credit Facility remain in full force and effect.

The foregoing description of the Fourth Amendment is qualified in its entirety by reference to the Fourth Amendment, a copy of which will be filed as an exhibit to the Company's Quarterly Report on Form 10-Q for the quarter ended March 31, 2021.

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