The study will evaluate the efficacy of ZEN-3694 + enzalutamide vs. single agent enzalutamide as measured by its primary endpoint, radiographic free progression.
Abiraterone, also an ARSI, is frequently prescribed as a first line therapy for patients with metastatic prostate cancer. A significant fraction of these patients, whose tumors have low androgen receptor (AR) signaling activity, have a sub optimal response to abiraterone and their subsequent treatment options are limited to cytotoxic therapies. The rationale for this study design is supported by a recent publication in
'We are delighted to initiate this study in collaboration with our partners Newsoara and Astellas to continue the development of ZEN-3694 in mCRPC patients,' said
Dr.
About Prostate Cancer
Prostate cancer is the second-most commonly diagnosed cancer among men and the fifth most common cause of male cancer death worldwide. Adenocarcinoma of the prostate is dependent on androgen for tumor progression and depleting or blocking androgen action has been a mainstay for over six decades. Although tumors are often initially sensitive to medical or surgical therapies that decrease levels of testosterone and to ARSIs that block AR signaling, disease progression ultimately occurs leading to mCRPC. The treatment of prostate cancer patients has evolved rapidly over the past ten years with second generation ARSIs. Despite these advances, many patients with mCRPC fail or develop resistance to existing treatments, leading to continued disease progression and limited survival rates.
About Astellas
About Newsoara
Newsoara is a biotech company based in
About Zenith
Zenith Capital Corp. is a biotechnology investment company originally spun out ofResverlogix Corp. (TSX: RVX) in 2013.Zenith Epigenetics Ltd. , a wholly-owned subsidiary ofZenith Capital Corp. , is a clinical stage biotechnology company focused on the discovery and development of novel therapeutics for the treatment of cancer and other disorders with significant unmet medical need. Zenith Epigenetics is developing various novel combinations ofBET inhibitors with other targeted agents. The lead compound, ZEN-3694, is in clinical development for: 1. mCRPC in combination with androgen receptor inhibitor, enzalutamide (XTANDI), with Astellas and Newsoara as collaborators. 2. Triple Negative Breast Cancer in combination with the PARP inhibitor TALZENNA withPfizer as a collaborator. 3. Androgen receptor independent mCRPC in combination with immune checkpoint inhibitor KEYTRUDA and XTANDI withUniversity of California, San Francisco as a collaborator. 4. Ovarian cancer in combination with immune-checkpoint inhibitors, nivolumab and ipilimumab in collaboration with theNational Cancer Institute . 5. Nut midline carcinoma in combination with chemotherapy in collaboration with theNational Cancer Institute .
Contact:
Tel: 587-390-7865
Email: info@zenithepigenetics.com
Web: www.zenithepigenetics.com
This news release may contain certain forward-looking information as defined under applicable Canadian securities legislation, that are not based on historical fact, including without limitation statements containing the words 'believes', 'anticipates', 'plans', 'intends', 'will', 'should', 'expects', 'continue', 'estimate', 'forecasts' and other similar expressions. In particular, this news release includes forward-looking information relating to the potential role of ZEN-3694 in the treatment of cancer and other disorders, and the Company's development of ZEN-3694 including its planned Phase 2b Randomized Metastatic Castration-Resistant Prostate Cancer (mCRPC) study. Our actual results, events or developments could be materially different from those expressed or implied by these forward-looking statements. We can give no assurance that any of the events or expectations will occur or be realized. By their nature, forward-looking statements are subject to numerous assumptions and risk factors including those discussed in our most recent MD&A which are incorporated herein by reference and are available through SEDAR at www.sedar.com. The forward-looking statements contained in this news release are expressly qualified by this cautionary statement and are made as of the date hereof. Zenith disclaims any intention and has no obligation or responsibility, except as required by law, to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.
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