Revelation Biosciences Inc. announced topline data for its Phase 1b CLEAR clinical study to evaluate the effect of intranasal REVTx-99b on nasal challenge allergen in participants with allergic rhinitis to rye grass pollen. The primary endpoint to evaluate the effects of REVTx-99b versus placebo on safety and tolerability was met. Exploratory endpoints for efficacy were not met.

This includes no reduction in allergy symptoms (Total Nasal Symptom Score) and no increase in peak nasal inspiratory flow versus placebo. The study enrolled two cohorts: one cohort received study drug prior to nasal allergen challenge (the prophylactic cohort) and the second cohort received study drug after the nasal allergen challenge (the treatment cohort). The Phase 1b, randomized, double-blind, placebo-controlled, crossover study design was conducted in Australia.

Revelation management plans to evaluate future development of this and other ongoing programs.