Press Release : Roche launches Elecsys Anti-p53 immunoassay to aid diagnosis of various cancer types

 
   -- Anti-p53 antibodies are antibodies that mistakenly target a patient's own 
      tissues, leading to a growth of solid tumors. 
 
   -- Screening for Anti-p53 helps to diagnose throat, bowel and breast cancers 
      earlier, thereby increasing the chances that a patient responds to a 
      treatment 
 
   -- The Elecsys Anti-p53 could be used to monitor cancer cell remnants in the 
      patient's body 
 
   Basel, 07 April 2021 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today 
announced the launch of the Elecsys Anti-p53 immunoassay for the in 
vitro quantitative determination of anti-p53 antibodies. This test is 
used to aid physicians to diagnose throat cancer, bowel cancer and 
breast cancer in patients, in conjunction with other diagnostic tests. 
The assay is now available for all markets accepting the CE Mark. 
 
 
 
   "The addition of our Elecsys Anti-p53 immunoassay will help clinicians 
to quickly and reliably diagnose several prevalent cancers and might 
assist in leading to a better prognosis for many patients.", said Thomas 
Schinecker, CEO Roche Diagnostics. "Beyond breakthrough cancer medicines, 
Roche also offers a growing number of testing solutions to help 
physicians diagnose and treat people with cancer. 
 
 
 
   p53 is protein which, when active, helps to regulate processes which 
stop tumors from developing. A mutation of p53 is present in half of 
solid tumor cancers and is the most common genetic change identified so 
far in human cancers.(1) Certain mutations of p53 can lead to a build up 
of p53 which results in the formation of anti-p53 autoantibodies. 
Autoantibodies are antibodies that mistakenly target and react with a 
person's own tissues. Between 20-50% of patients with mutated p53 will 
produce anti-p53 autoantibodies.(2) This mutation causes the tumor 
suppressive function of p53 to switch to a tumor-promoting function and 
thus cancer development. 
 
 
 
   Early appearance of anti-p53 antibodies during tumour development may 
have potential to detect malignant changes.(3) The Elecsys Anti-p53 
immunoassay detects these anti-p53 antibodies and, when used with other 
diagnostic tests, can help to diagnose certain cancers, at an earlier 
stage, which may help to improve patient outcomes. Determining the 
presence of anti-p53 antibodies may also be useful for monitoring 
cancerous cells that are still in the body following treatment.(4) In 
addition, the Elecsys Anti-p53 test could aid in determining which 
patients may require less invasive treatment procedures, as part of 
their cancer treatment. 
 
 
 
   About Elecsys Anti-p53 
 
   Elecsys Anti-p53 immunoassay for the in vitro quantitative determination 
of anti-p53 autoantibodies in human serum and plasma. Elecsys Anti-p53 
is a high precision immunoassay, with a low turn-around time for testing, 
complementing our overall tumor marker portfolio.  The new Elecsys 
Anti-p53 immunoassay uses the well-established electrochemiluminescence 
immunoassay "ECLIA" technology and is intended for use on cobas e 
immunoassay analyzers. 
 
   For further information on Elecsys immunoassays visit 
https://www.globenewswire.com/Tracker?data=OFh5-DMScoDJWAWjTQjpGnkwWG40yJalCF2tjqceDfzrPlTpwBpooI-EsXD1O-j82u8l5HZQps5g2FVDgScTj6ncnImPX4wnlKP33UXbLYaGrOP3ngJ2uhv9XRht4QyC5fnUoQih3ySzuBC23gmCun9OestnI_CVytpBHGsfSnE= 
here. 
 
 
 
   About Roche 
 
   Roche is a global pioneer in pharmaceuticals and diagnostics focused on 
advancing science to improve people's lives. The combined strengths of 
pharmaceuticals and diagnostics under one roof have made Roche the 
leader in personalised healthcare -- a strategy that aims to fit the 
right treatment to each patient in the best way possible. 
 
 
 
   Roche is the world's largest biotech company, with truly differentiated 
medicines in oncology, immunology, infectious diseases, ophthalmology 
and diseases of the central nervous system. Roche is also the world 
leader in in vitro diagnostics and tissue-based cancer diagnostics, and 
a frontrunner in diabetes management. 
 
 
 
   Founded in 1896, Roche continues to search for better ways to prevent, 
diagnose and treat diseases and make a sustainable contribution to 
society. The company also aims to improve patient access to medical 
innovations by working with all relevant stakeholders. More than thirty 
medicines developed by Roche are included in the World Health 
Organization Model Lists of Essential Medicines, among them life-saving 
antibiotics, antimalarials and cancer medicines. Moreover, for the 
twelfth consecutive year, Roche has been recognised as one of the most 
sustainable companies in the Pharmaceuticals Industry by the Dow Jones 
Sustainability Indices (DJSI). 
 
 
 
   The Roche Group, headquartered in Basel, Switzerland, is active in over 
100 countries and in 2020 employed more than 100,000 people worldwide. 
In 2020, Roche invested CHF 12.2 billion in R&D and posted sales of CHF 
58.3 billion. Genentech, in the United States, is a wholly owned member 
of the Roche Group. Roche is the majority shareholder in Chugai 
Pharmaceutical, Japan. For more information, please visit 
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www.roche.com. 
 
 
 
   All trademarks used or mentioned in this release are protected by law. 
 
 
 
   References 
 
   [1] Yue X, et al. J Mol Biol 2017;429:1595-606 
 
   [2] Suppiach et al. World J Gastroenterol 2013 August 7; 19(29): 
4651-4670 
 
   [3] Soussi T. Cancer Res 2000;60:1777-88 
 
   [4] Kastenhuber E & Lowe S. Cell 2017;170(6):1062-78 
 
   Roche Group Media Relations 
 
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(END) Dow Jones Newswires

April 07, 2021 01:00 ET (05:00 GMT)