Item 2.06 Material Impairments.

On December 1, 2022, Royalty Pharma plc (the "Company") concluded that a non-cash impairment charge related to the financial royalty asset associated with gantenerumab is required under generally accepted accounting principles of the United States ("GAAP") in the three months ending December 31, 2022. This non-cash impairment charge will not impact the Company's non-GAAP financial results. On November 30, 2022, Roche stated that it would discontinue clinical trials of gantenerumab after the GRADUATE I and II studies evaluating gantenerumab in people with early Alzheimer's disease did not meet their primary endpoint of slowing clinical decline, which led the Company to conclude its financial royalty asset is impaired. The Company expects that the non-cash impairment charge will be $273.6 million, which was the net carrying value of the asset as of September 30, 2022. No portion of the impairment charge relates to future cash expenditures.

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