Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

On November 17, 2021, Joseph S. Zakrzewski, a member of the Board of Directors (the "Board") of Sangamo Therapeutics, Inc. (the "Company"), notified the Company of his voluntary resignation from the Board effective March 1, 2022. Mr. Zakrzewski's resignation is not due to any disagreement with the Company on any matter relating to the Company's operations, policies or practices.

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