NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN ANY JURISDICTION IN 
WHICH IT WOULD BE UNLAWFUL TO DO SO 
 
   Pratteln, Switzerland, April 6, 2021 -- Santhera Pharmaceuticals (SIX: 
SANN) gives an update on the restructuring of its CHF 60 Million 
Convertible Bonds and the options from which bondholders may choose. 
 
   As from today, April 6, 2021, holders of Santhera's outstanding CHF 60 
million 5% Convertible Bonds due 2022 (the 2017/22 Bonds) are able to 
accept the exchange offer that Santhera had announced on March 25, 2021, 
subject to applicable offer restrictions. The exchange offer is open for 
acceptance until Monday, April 19, 2021, 5:00 p.m. CEST, unless extended 
by Santhera. The interim results of the exchange offer are expected to 
be published on April 20, 2021. If Santhera declares the exchange offer 
successful, an additional acceptance period is expected to begin on 
April 21, 2021, and end on April 27, 2021, 5:00 p.m. CEST. 
 
   In parallel, Santhera continues to seek and obtain additional consents 
to the restructuring of the 2017/22 Bonds it had proposed to the 
bondholders' meeting of March 8, 2021. The amendments proposed to the 
bondholders' meeting and the terms offered in the exchange offer are 
economically the same, mutatis mutandis. Hence Santhera encourages 
bondholders to submit their consent, if not already done, and accept the 
exchange offer. Santhera still requires further votes in order to reach 
the necessary two thirds majority. If a two thirds majority is achieved, 
the bondholders' resolution would, subject to court approval, become 
binding on all bondholders, and the exchange offer would not be 
completed. 
 
   "The recent support of Santhera's shareholders in approving additional 
capital has paved the way for a restructuring of our outstanding bond. 
In order to achieve this, we encourage all bondholders to consider this 
exchange offer in addition to the ongoing consent process," said Dario 
Eklund, CEO of Santhera. "Such a restructuring of Santhera's capital 
structure is the best way to secure the Company's operations past the 
6-month VISION-DMD data readout, after which, if positive, we will seek 
additional financing to fuel our future growth plans." 
 
   Currently, bondholders may both and simultaneously 
 
   (1)           vote on the bondholder's resolution (if they have held the 
bonds since March 5, 2021, or earlier, and if they have not already 
voted), and 
 
   (2)           accept the exchange offer 
 
   These two decisions are completely independent from each other. A vote 
for the bondholders' resolution does not constitute an acceptance of the 
exchange offer, and acceptance of the exchange offer does not constitute 
a vote for the restructuring proposed to the bondholders' meeting. 
 
   To vote on the bondholders' resolution, bondholders should fill out and 
submit the forms that are published on the Santhera website under 
https://www.globenewswire.com/Tracker?data=1f-D_X5cR9NkFkTXT7DAjUFOqfuxAjQqR3F93rJE0WM4r7nw2zRa5lvUx3JAStxALZPyMa79p8VTwZl7C91tVsphUoFDkdqg8_olUDeQWq4QzmrhP0cRSXUL985j8M4IpCZul4LlNXF_N6Gx2A2LAwPEWCCrHEc8-Ewfp5heZjHvC4pBoLfWTq239_68tYJGd5QEkVVPdmbP3nctHgScUEzBEf_xdfL_MLoQLfb7FVza7EpPd9xsPURCzcwXma_3 
www.santhera.com/investors-and-media/investor-toolbox/share-bondholder-meetings. 
 
 
   To accept the exchange offer, bondholders should instruct their custody 
bank accordingly. 
 
   Bondholders requiring assistance or additional information on the 
procedures are invited to contact Santhera Pharmaceuticals Holding AG, 
Hohenrainstrasse 24, 4133 Pratteln (email: 
https://www.globenewswire.com/Tracker?data=-Cd5zCRzWFTjP4sEt8NpHgS-3s-2L8lpQYSHXVyL7EWGzQkeiCyRnfS8D01xUhX6OIGaLJz-xLxD12kzaXyeHJfF5t_vLN9G8lKO6acN4Dp0p4v1u8J_bH_UiTw6ydvv 
daniela.glatz@santhera.com; phone: +41 61 906 89 50). 
 
   Related Documents 
 
   Forms to cast bondholder votes are available 
https://www.globenewswire.com/Tracker?data=24_i7J1efQpTJ5TlB47PPDgybO_7IfbpIJ_IbxPwXJBBjX-CGgVbXhUImLWxEQcr2cZ2gOswpoTs_QbBZiecY1v202yw36JAkmGwfSxZfJdGKMf3sWKxu_pkqFMRiBZYQxyhF_2Us2T4Vuz0VUgQWVhUjl14gl262iS3beglFCY= 
here. 
 
   Invitation to the Bondholders' Meeting (March 8, 2021), the EGM (March 
18, 2021) and accompanying documents: 
https://www.globenewswire.com/Tracker?data=UoX_FxfJDQbv_0tzW-HbU5bw-zN3N36ucX1gA0MaqGL9pg-WDNAPpAAOOfWm4ulKvdPNAatO6_RfUdpYgO267-gDf3LfyWykZs7koxm7ZbWZX1iPbbae6z5f92doqHIoWqAY2GaMiESaz34GdFmY6f_kCe18ksmuC4JOQMC0LHjZ0R5lXvk3gCHmB1olOEx-BvxVwyuEw1dWhIrEMMTFGBQA9RgzrpwVPQhKkPLYMocfYiL_sYTRUiGbZLq2BU0x6mkaPQLAgC9n29D48DcgoQ== 
http://www.santhera.com/investors-and-media/investor-toolbox/share-bondholder-meetings 
 
 
   Notice of a Repurchase Offer (Exchange of CHF 60,000,000 Senior 
Unsecured Convertible Bonds due 2022): 
https://www.globenewswire.com/Tracker?data=UoX_FxfJDQbv_0tzW-HbUzgj2bpImCt8VPwmJDTRz_WVVGee5sjH5NG_Mxkyyenr1EvZkXZwB0FDXyw8ZqvN_hiJgRzLziLFmTTcD2kFfTHrFoGpK1bgXjuu5P92VK5E387Pezz3S6X7IjKvy34irlVUDq1LdTJTRH8T0IK-OOJ5xuPhMMClfWmdKND9hYETJby2PzQ0fSyyXEWUkVJr2Z8hUs-WdRTQqVd-jpIVkvp4D_Co_pdpw6FL1Xw3QSpfvFejywBpmsRjUj4tgHYf3g== 
https://www.santhera.com/investors-and-media/investor-toolbox/bond-exchange-offering 
 
 
   Preliminary Issuance and Listing Prospectus Regarding the New Bonds: 
https://www.globenewswire.com/Tracker?data=UoX_FxfJDQbv_0tzW-HbUzgj2bpImCt8VPwmJDTRz_WVVGee5sjH5NG_Mxkyyenr1EvZkXZwB0FDXyw8ZqvN_hiJgRzLziLFmTTcD2kFfTHrFoGpK1bgXjuu5P92VK5ElXx1Z_W12S3hMmo36aQf5h_B_eb0SbKZIhyK5EJp8wMzAplxMHH1l1uaO7krUrTLcwXqd3sQLZPXSTti1dfxTKMDOWz2o84BabKIyMoZI3PbIUfkXkLYjbuP7hdXAwwTe2BkUwklLaNnO199aP2AUg== 
https://www.santhera.com/investors-and-media/investor-toolbox/bond-exchange-offering 
 
 
   Corporate calendar 
 
   April 27, 2021         Publication of annual results and Annual Report 
2020 
 
   June 22, 2021         Annual General Meeting 
 
   About Santhera 
 
   Santhera Pharmaceuticals (SIX: SANN) is a Swiss specialty pharmaceutical 
company focused on the development and commercialization of innovative 
medicines for rare neuromuscular and pulmonary diseases with high unmet 
medical need. Santhera has an exclusive license for all indications 
worldwide to vamorolone, a first-in-class dissociative steroid with 
novel mode of action, currently investigated in a pivotal study in 
patients with DMD as an alternative to standard corticosteroids. The 
clinical stage pipeline also includes lonodelestat (POL6014) to treat 
cystic fibrosis (CF) and other neutrophilic pulmonary diseases, as well 
as an exploratory gene therapy approach targeting congenital muscular 
dystrophies. Santhera out-licensed ex-North American rights to its first 
approved product, Raxone(R) (idebenone), for the treatment of Leber's 
hereditary optic neuropathy (LHON) to Chiesi Group. For further 
information, please visit 
https://www.globenewswire.com/Tracker?data=1f-D_X5cR9NkFkTXT7DAjd2b8WuIM9eHwi-NJTolhgLd0C8knfDniPdPFJWBVkCaa0ZlbHPQGl-R-R5CnHfc9g== 
www.santhera.com. 
 
   Raxone(R) is a trademark of Santhera Pharmaceuticals. 
 
   For further information please contact: 
 
   https://www.globenewswire.com/Tracker?data=XMvDzcLCRpVJSIHfBVtKQ-gnrP8wX5lKckqf0Q9wFAdIE-d4DyHzq7qvWd0njABHeZPEYD2tbeVVij2aobGDJfkwA7mw2X8Vfhb3ixiqT4d5t7NezsaV_8ylb9E8nxuM 
public-relations@santhera.com or 
 
   Eva Kalias, Head External Communications 
 
   Phone: +41 79 875 27 80 
 
   eva.kalias@santhera.com 
 
   Forward-looking statements 
 
   This communication does not constitute an offer or invitation to 
subscribe for or purchase any securities of Santhera Pharmaceuticals 
Holding AG. This publication may contain certain forward-looking 
statements concerning the Company and its business. Such statements 
involve certain risks, uncertainties and other factors which could cause 
the actual results, financial condition, performance or achievements of 
the Company to be materially different from those expressed or implied 
by such statements. Readers should therefore not place undue reliance on 
these statements, particularly not in connection with any contract or 
investment decision. The Company disclaims any obligation to update 
these forward-looking statements. 
 
   Offer Restrictions 
 
   The Exchange Offer is not being made and will not be made, directly or 
indirectly, in any country or jurisdiction in which the Exchange Offer 
would be considered unlawful or otherwise violate any applicable laws or 
regulations, or which would require the Company or any of its 
subsidiaries to change or amend the terms or conditions of the Exchange 
Offer in any material way, to make an additional filing with any 
governmental, regulatory or other authority or take additional action in 
relation to the Exchange Offer. It is not intended to extend the 
Exchange Offer to any such country or jurisdiction. Any such document 
relating to the Exchange Offer must neither be distributed in any such 
country or jurisdiction nor be sent into such country or jurisdiction, 
and must not be used for the purpose of soliciting the purchase of 
securities of the Company by any person or entity resident or 
incorporated in any such country or jurisdiction. 
 
   United States 
 
   The Exchange Offer is being made in the United States in reliance on, 
and compliance with, Section 14(e) of the US Securities Exchange Act of 
1934 and Regulation 14E thereunder. 
 
   The Company, certain affiliated companies and the nominees or brokers 
(acting as agents) may make certain purchases of, or arrangements to 
purchase, 2017/22 Bonds outside the Exchange Offer during the period in 
which the Exchange Offer remains open for acceptance. If such purchases 
or arrangements to purchase are made they will be made outside the 
United States and will comply with applicable law, including the 
Exchange Act. 
 
   The Company as the offeror is a Swiss company. Information distributed 
in connection with the Exchange Offer is subject to Swiss disclosure 
requirements that are different from those of the United States. 
Financial statements and financial information included herein are 
prepared in accordance with Swiss accounting standards that may not be 

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