Seagen to Highlight New Research from its Diverse Pipeline of Targeted Cancer Therapy Candidates at the Society for Immunotherapy of Cancer's (SITC) Annual Meeting

Seagen Inc. (Nasdaq: SGEN) today announced that data from the company's diverse pipeline of targeted cancer therapy candidates will be presented at the Society for Immunotherapy of Cancer's (SITC) Annual Meeting being held November 8-12 in Boston.

The presentations highlight data from multiple ongoing clinical and preclinical research studies that employ Seagen's proprietary antibody-drug conjugate (ADC) technology, as well as other novel cancer targeting approaches.

'Seagen has a deep heritage in pioneering first-in-class antibody-drug conjugates. We are encouraged by initial results from a clinical study of SGN-B6A, a wholly owned investigational antibody-drug conjugate that demonstrated antitumor activity with an acceptable safety profile in previously treated patients with non-small cell lung cancer, head and neck cancer, and esophageal cancer,' said Megan O'Meara, M.D., Senior Vice President of Early-Stage Development at Seagen. 'We are also sharing new data demonstrating enhanced preclinical activity of enfortumab vetodin in combination with immune checkpoint inhibitors, as well as preclinical data that support the initiation of a first-in-human study of a bispecific molecule called SGN-BB228.'

Highlights From SGN-B6A Program Presented at SITC

Data from an ongoing Phase 1 study of SGN-B6A, an ADC directed to integrin beta-6, which is overexpressed in multiple solid tumors, showed early efficacy signals in at least three cancer types, including non-small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), and esophageal squamous cell carcinoma (ESCC).

Dose escalation cohorts enrolled 79 participants with metastatic or unresectable solid tumors, whose disease had relapsed or was refractory to standard of care therapies and had not previously received an MMAE-containing agent or agent targeting integrin beta-6. Participants had received a median of 3 lines of therapy for metastatic disease prior to enrollment in the study. SGN-B6A demonstrated a manageable and tolerable safety profile at the explored dose levels and schedules. Intermittent dosing schedules (2Q3W, 2Q4W) are being evaluated further. The initial anti-tumor activity observed in heavily pre-treated patients is encouraging and has triggered expansion cohorts in NSCLC, HNSCC, and ESCC, which are currently ongoing. SGN-B6A is an investigational agent, and its safety and efficacy have not been established.

About Seagen

Seagen Inc. is a global biotechnology company that discovers, develops and commercializes transformative cancer medicines to make a meaningful difference in people's lives. Seagen is headquartered in the Seattle, Washington area and has locations in California, Canada, Switzerland and the European Union.

Forward-Looking Statements

Certain of the statements made in this press release are forward-looking, such as those, among others, relating to the potential of SGN-B6A, SGN-BB228, SGN-B7H4V, SEA-CD40, enfortumab vedotin and disitamab vedotin and Seagen's other products and product candidates, their potential efficacy, safety and therapeutic uses, plans for presenting at the referenced medical conference, plans with respect to clinical trials, and the potential of the company's pipeline. Actual results or developments may differ materially from those projected or implied in these forward-looking statements. Factors that may cause such a difference include, without limitation, the difficulty and uncertainty of pharmaceutical product development even after encouraging results in early-stage trials or preclinical research, the risk of adverse events or safety signals, the inability to show sufficient efficacy in clinical trials and the possibility of adverse regulatory actions. More information about the risks and uncertainties faced by Seagen is contained under the caption 'Risk Factors' included in the company's Quarterly Report on Form 10-Q for the quarter ended September 30, 2022, filed with the Securities and Exchange Commission. Seagen disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.

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