SeaSpine : Corporate Presentation August 2022

Operate in the Now

August 2, 2022

©2022 SeaSpine Orthopedics Corporation. All rights reserved | 1

Forward-looking Statements & Disclaimer

This presentation includes statements that may be forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. The words "believe," "estimate," "expect," "anticipate," "project," "forecast" and similar expressions, or the negative thereof, among others, generally identify forward-looking statements. Forward- looking statements used in this presentation include revenue guidance; future revenue and revenue growth; liquidity to fund growth; new product launches and market opportunity, market share and market share growth. SeaSpine® cautions that these forward-looking statements are based on management's current expectations, estimates, forecasts and projections, and assumptions management believes are reasonable, and are subject to risks and uncertainties that may cause actual results to differ materially from those indicated in the forward-looking statements. Such risks and uncertainties include, but are not limited to, the ongoing impact of the COVID-19 pandemic on the elective surgery market and the global healthcare system generally; risks that the COVID-19 pandemic may disrupt the Company's business and/or the global healthcare system more severely than anticipated; surgeons' willingness to use the Company's existing and newly launched products; the Company's ability to continue to invest in medical education and training, product development, and/or sales and marketing initiatives at levels sufficient to drive future revenue growth; the Company's ability to attract new, high-quality distributors and potential disruption to the Company's existing distribution network; continued pricing pressure, as well as exclusion from major healthcare systems; the risk of supply shortages and the associated, potentially long-term disruption to product sales; unexpected expense and delay; changes to laws and regulations applicable to the Company and the industry in which it competes; and general economic and business conditions in the markets in which the Company does business, both in the U.S. and abroad. Additional information about the factors that may affect the operations of SeaSpine and results is set forth in SeaSpine's annual and quarterly reports filed with the U.S. Securities and Exchange Commission. Forward-looking statements contained in this presentation are made only as of the date set forth on the cover hereof and SeaSpine undertakes no obligation to release publicly any revisions or updates to forward-looking statements as a result of subsequent events or developments, except as required by law.

©2022 SeaSpine Orthopedics Corporation. All rights reserved | 2

Sea Beyond

SeaSpine® is uniquely transforming the OR with safe, fast, real-time solutions that give surgeons & hospital partners

confidence and deliver better outcomes to improve patient lives - NOW.

©2022 SeaSpine Orthopedics Corporation. All rights reserved | 3

Transformative

Solutions

at Every Level.

In Real-time -

Operate

in the Now.

©2022 SeaSpine Orthopedics Corporation. All rights reserved | 4

7D Surgical Navigation

Unique Value Proposition

Leading the charge in accuracy,

safety and hospital economic benefit

FLASH™		SEGMENTAL		RADIATION-		SURGEON		FLEXIBLE
REGISTRATION		REGISTRATION		FREE FOR OPEN		CONTROL		PURCHASE
				PROCEDURES				OPTIONS

©2022 SeaSpine Orthopedics Corporation. All rights reserved | 5