Shattuck Labs, Inc. announced a strategic pipeline prioritization to include the discontinuation of its clinical program, SL-172154. The Company will turn its focus to SL-325, its DR3 antagonist antibody, and plans initial clinical development in patients with IBD, where TL1A/DR3 blocking antibodies have demonstrated compelling monotherapy efficacy. Top-line Phase 1B SL-172154 Clinical Trial Results: HR-MDS: InterimOverall Survival (OS) analysis was completed on September 3, 2024.

Overall Survival: Current median OS of 15.6 months. The median survival for patients with TP53m HR-MDS is currently 10.6 months and will not improve beyond 13.1 months with subsequent data cuts. Benchmark Data: Benchmark median OS of approximately 9?12 months for TP53m HR-MDS patients treated with azacitidine alone.

Safety and Tolerability: No deaths have occurred in patients (n=3) without TP53m. SL-172154 showed a manageable safety profile with Infusion-Related Reactions (IRRs) as the most common SL-172154 treatment-emergent adverse events (TEAEs). TP53m AML InterimOS analysis was completed on September 3, 2024.

Overall Survival: Current median OS is 10.5 months and will not improve beyond 11.7 months with subsequent data cuts. Benchmark Data: Benchmark median OS of approximately 5-8 months for TP53m AML patients treated with azacitidine alone. Safety and Tolerability: SL-172154 showed a manageable safety profile with IRRs as the most common SL-172154 treatment-emergent adverse events TEAEs.