Shield Therapeutics : Results for the Year Ended 31 December 2021 - Investor Presentation

Preliminary results for the year ending

31 December 2020

Tim Watts, CEO

Hans-Peter Rudolf, CFO

April 2021

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2020 operational highlights (including post-period end)

During 2020

• Feraccru® licensed to ASK Pharm in China
• AEGIS-H2Hre-analysis confirms Feraccru®/Accrufer® is a credible alternative to IV therapy for iron deficiency anaemia
• Teva withdraw all oppositions to Shield's European patents
• 2020 sales of Feraccru® packs increase by 70% in Germany and UK compared with 2019
• First stage of paediatric study conducted successfully

Post period end

• £29 million gross proceeds raised by means of placing, subscription and open offer
• Decision made for Shield to launch Accrufer® in US

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US opportunity

Accrufer® Market Opportunity Overview

• Iron deficiency is a large, diverse and undertreated market
• • ~10 million ID patients in US: ~5 million patients treated annually for IDA
  • Existing 1st line therapies are poorly tolerated iron salts: ~10-11 million TRx annually
  • 2nd line therapy is intravenous (IV) iron which is inconvenient for patients with expensive administration costs
  • • ~ 2.3 million doses yearly
    • Annual IV iron sales ~$1.2 billion
• Prescriber market research highlights the need for an effective, well-tolerated oral iron option
• Payer market research indicates that Accrufer® should have few restrictions at
  WAC (gross price) of ~$500/pack (1 month's supply containing 60 capsules)
• COVID-19is changing healthcare delivery and recommendations for the care of at- risk patients
• • Increased use of telemedicine
  • Recommendations to consider home treatments and/or switching patients from IV to oral therapies to minimise exposure

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