SHANGHAI (Reuters) - China's top economic planning agency is investigating costs and prices charged by drugmakers, including units of GlaxoSmithKline (>> GlaxoSmithKline plc) and Merck (>> Merck & Co., Inc.), as foreign firms come under pressure from Beijing over possible price-fixing.

The move follows a separate probe into instant milk powder, which has already led to price cuts.

The National Development and Reform Commission (NDRC) is surveying production costs and prices charged at multiple foreign and Chinese drug companies, according to a July 2 statement from the commission.

News of the investigation was reported earlier on Thursday by the official Securities Daily newspaper.

The NDRC will examine 27 companies on cost issues and 33 for pricing. The investigation is being done to understand the cost and pricing situation within the companies, and to adjust drug prices in a timely manner, the agency said.

In addition to GSK and Merck, other foreign companies being investigated over costs include Astellas (>> Astellas Pharma Inc), Novartis's (>> Novartis AG) generics unit Sandoz, Boehringer Ingelheim, Baxter International (>> Baxter International Inc.) and Fresenius (>> Fresenius SE & Co KGaA).

An investigation team from NDRC will visit the companies involved between July and October, the agency said.

One industry source familiar with the situation said the probe appeared to be focused on so-called transfer pricing, which determines how costs are distributed between units of large companies. Beijing plans to analyse the difference in prices of imported products sold by foreign firms in China compared with those in other markets.

The NDRC has also been investigating potential price-fixing and anti-competitive behaviour by five instant milk powder makers, including Swiss food company Nestle (>> Nestle SA) and French rival Danone (>> DANONE).

In response, Nestle and Danone said on Wednesday they were cutting the price of infant formula milk in China.

GSK OPERATIONS IN FOCUS

The NDRC probe into GlaxoSmithKline comes as high-level Chinese staff at the firm are being investigated by police in a separate case in the south-central Chinese city of Changsha on suspicion of economic crimes.

Changsha police have not provided any further details about the investigation and a GSK spokesman in London said it remained unclear what the investigation was about.

An anonymous whistleblower earlier made allegations that GSK sales representatives in China were involved in widespread bribery to get doctors to prescribe the company's medicines.

However, GSK said it had investigated the allegations thoroughly and found no evidence of any wrongdoing. It is not clear if the Changsha police investigation is related to these bribery allegations.

China is an increasingly important market for international pharmaceutical companies, which are relying on growth in emerging markets to offset slower sales in Western markets where many former blockbuster drugs have lost patent protection.

IMS Health, which tracks pharmaceutical industry trends, expects China to overtake Japan as the world's second biggest drugs market behind the United States by 2016.

(Additional reporting by Ben Hirschler in London; editing by Jeremy Laurence, Ron Askew)

By Kazunori Takada