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On or about May 11, 2021, Simulations Plus, Inc., a California corporation (the 'Company'), mailed a proxy statement (the 'Proxy Statement') to its shareholders relating to a special meeting of the Company's shareholders (the 'Special Meeting'), which Special Meeting is to be held on Wednesday, June 23, 2021, at 2:00 p.m. Pacific Time, virtually via live webcast through www.virtualshareholdermeeting.com/SLP2021. The Proxy Statement included a proposal to approve the Company's adoption of a new 2021 Equity Incentive Plan (the '2021 Plan').

As disclosed in the Current Reports on Form 8-K and supplemental proxy materials filed with the Securities and Exchange Commission ('SEC') by the Company on June 8, 2021 and June 10, 2021 (collectively, the 'Supplemental Proxy Materials'), on June 3, 2021 and June 9, 2021, respectively, Institutional Shareholder Services Inc. ('ISS') published proxy analysis and vote recommendations for the Special Meeting (the 'ISS Recommendations'), both of which included an unfavorable recommendation from ISS with respect to the Company's adoption of the 2021 Plan. In response to the ISS recommendations to vote 'against' the proposal to approve the 2021 Plan, (i) on June 8, 2021, the Company revised the 2021 Plan to decrease the total number of shares of common stock authorized and reserved for issuance under the 2021 Plan from 2,100,000 shares (as originally proposed) to 1,300,000 shares (as revised, the 'Revised 2021 Plan'), and (ii) on June 10, 2021 the Company publicly disclosed additional and updated information regarding equity awards granted, outstanding and reserved for issuance under our equity incentive plans.

On June 11, 2021, after reviewing the Supplemental Proxy Materials filed with the SEC, ISS published an updated proxy analysis and vote recommendation for the Special Meeting, pursuant to which it changed its prior recommendations and recommended that the Company's shareholders vote 'for' the adoption of our Revised 2021 Plan at the Special Meeting.

Except as set forth above and in the Supplemental Proxy Materials filed with the SEC on June 8, 2021 and June 10, 2021, respectively, the Proxy Statement remains unchanged. The Revised 2021 Plan will be presented for shareholder approval at the Special Meeting. The Company's Board of Directors continues to recommend unanimously that shareholders vote 'for' the proposal in the Proxy Statement, as supplemented by this supplement, to approve the Company's Revised 2021 Plan. Any vote 'for' or 'against' the 2021 Plan proposal using the proxy card previously furnished to the shareholders of record as of April 26, 2021, the record date for the Special Meeting, or the voting instruction card made available to the beneficial owners by their broker, bank or another nominee will be counted as a vote 'for' or 'against,' as applicable, the Revised 2021 Plan. If any shareholder has already returned his or her properly executed proxy card or voted via the Internet or by telephone and would like to change his or her vote on any matter, such shareholder may revoke his or her proxy before it is voted at the Special Meeting by submitting a new proxy bearing a later date via the Internet, by telephone, by mail or by attending the Special Meeting virtually and casting the online ballot, or as otherwise described in the Proxy Statement. If any shareholder would like a new proxy or has any questions, he or she should contact Will Frederick, the Company's Chief Financial Officer and Corporate Secretary, at 42505 10th Street West, Lancaster, CA 93534, or at (661) 723-7723.

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Simulations Plus Inc. published this content on 11 June 2021 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 11 June 2021 19:06:08 UTC.