SINOMED announced that the clinical trial results for its HT Supreme? Drug-Eluting Stent (DES) System has been published in Circulation. The article described results from the PIONEER III trial where investigators demonstrated equivalence in safety and effectiveness between the HT Supreme and best-in-class DES. The PIONEER III study enrolled 1,629 patients from centres in Belgium, Canada, France, Germany, Japan, Netherlands, Spain, Switzerland, U.K., and the U.S.A. This tri-continent trial had a primary composite endpoint of target lesion failure (TLF) at one-year. The TLF outcomes showed that the HT Supreme met the non-inferiority endpoint at 5.4% compared to 5.1% from the control arm (p=0.002) of Xience and Promus devices (DP DES). A grouped analysis of secondary endpoints showed a numerically better result for HT Supreme in cardiac death or target-vessel myocardial infarction (TV MI) with 3.5% in the HT Supreme arm compared to 4.6% in the control arm (p=0.27). Lower late stent thrombosis data (0.1% compared to 0.4%, p=0.22) also suggested exceptional safety for the HT Supreme. A powered, landmark TLF analysis evaluating the healing superiority of HT Supreme between 1 and 5 years is ongoing. Data from this trail will be submitted to the U.S. Food and Drug Administration (FDA) for approval in the U.S.A. and the and Pharmaceuticals and Medical Devices Agency (PMDA) for approval in Japan. The HT Supreme represents a novel class of stents that highlights the importance of early, timely healing. Through patented designs and proprietary processes, the HT Supreme is tailored to help patients accelerate their wound-healing process and restore their naturally protective vessel function. The HT Supreme was launched this summer in Europe and China.