Solasia Pharma K.K. officially announced egarding SP-04 PledOx® development status. The results of the non-clinical study conducted since 2021 at the University of Milan, Italy, using a rat model of Taxane-induced peripheral neuropathy are now available, and have evaluated the results with Egetis Therapeutics AB, the licensor of SP-04 PledOx®, and Professor Cavaletti of the University of Milan, who was responsible for conducting the study. The results of the study suggest that SP-04 PledOx® may have protective effect on Taxane-induced peripheral neuropathy in terms of the evaluation of some of the parameters predefined in the study protocol.

On the other hand, other parameters did not show the same results, and the overall interpretation of the study result was complicated and did not confirm a clear protective effect on the onset of Taxane-induced peripheral neuropathy. A new animal study will be planned based on the useful information suggested by this study.