Stryker : 2021 Comprehensive Report

2021 in review

Table of contents

2021 in review
Game-changing innovations......................................................................	2
Our company..............................................................................................	5
A message from Stryker Chair and CEO...................................................	6
Innovating for growth.............................................................................	10
Financial highlights..................................................................................	12
Our corporate responsibility journey......................................................	14
Stronger people
Healthcare providers and patients..........................................................	17
Employees................................................................................................	24
Communities............................................................................................	38
Good business
Governance..............................................................................................	42
Information security and privacy...........................................................	47

Business ethics and ethical marketing....................................................	49
Product quality and safety......................................................................	53
Supply chain management......................................................................	56
Healthier planet
Operational impact..................................................................................	61
Product design and lifecycle management.............................................	69
Data summary
References................................................................................................	72
About this report......................................................................................	75
Legal disclaimers.....................................................................................	76
Non-GAAP reconciliation.........................................................................	77

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2021 Comprehensive Report

2021 in review

Patient impact

Game-changing

innovations

With the help of Blueprint technology, a surgeon restores the shoulder- and the hope-of a former Major League Baseball (MLB) pitcher.

One moment, Jeff Brantley was reaching into the refrigerator for a carton of milk. The next, a jolt of pain overtook his extended right arm. The

carton came crashing to the floor as his son

looked on in surprise.

That same arm used to throw strike after strike during Jeff's 14 seasons as a relief pitcher.

Now a broadcaster for the Cincinnati Reds, the baseball great led the National League in

saves in 1996, played in the MLB All-Star Game in 1990 and was inducted into the Mississippi Sports

Hall of Fame in 2010. As his baseball career progressed, though, Jeff's shoulder slowly deteriorated.

"The problem that you have being a pitcher is the repetitive motion on one side of your body, over and over and over. Especially with your shoulder and elbow," Jeff says. By his fifties, despite having undergone multiple surgeries, he was plagued by weakness and pain.

"I was really concerned because I'm right- handed," Jeff says. "I can't even get a carton of milk out of the refrigerator? I'm a pro athlete. I should be able to do that in my sleep."

The problem that you have being a pitcher is the repetitive motion on one side of your body, over and over and over. Especially with your shoulder and elbow."

Jeff Brantley

Patient

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2021 in review

Desperate to alleviate the pain and to finally play catch with his son, Jeff consulted longtime Cincinnati Reds medical director Dr. Tim Kremchek, who referred him to Dr. Andrew Razzano.

Dr. Razzano-a knee, shoulder and elbow specialist- proposed a solution: shoulder arthroplasty, commonly known as total shoulder replacement. Jeff was hesitant, but Dr. Razzano gave him confidence by using Stryker's Blueprint 3D Planning software to walk him through the procedure from every angle. Beyond aiding in patient communication, Dr. Razzano and many other orthopaedic surgeons use Blueprint to prepare for operations by visualizing each procedure in advance. This allows for precise and reproducible 3D measurements and leads

to improved decision-making, Dr. Razzano says.1,2,3 "If, in the O.R., something happens and you have to change

your plan, you've already done it in a virtual model. You don't have to think as much on the fly."

Thousands of miles away, Dr. Ruth Delaney recently became the first surgeon in Ireland to use Blueprint's new Mixed

Reality software. Originally unveiled by Wright Medical- which Stryker acquired in November 2020-the latest generation of Blueprint allows doctors to interact with their 3D pre-operative plan as they perform surgery (see sidebar below).

Introducing Blueprint Mixed Reality

Developed by pioneering orthopaedic surgeons from around the globe, the latest generation of Stryker's Blueprint technology is transforming the way shoulder surgeries are performed. Using a mixed reality headset, the software allows surgeons to view 3D versions of their patients' pre-operative plans and anatomy while in the operating room.

"When we first started on the journey to create this

software, we likened it to the difference between a smartphone and a flip phone," says Dr. Jon J.P. Warner, co-chief of shoulder services at Boston Shoulder Institute. After decades of relying on 2D CT scans, Blueprint Mixed Reality puts critical patient information at surgeons' fingertips.

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"With Mixed Reality, we can see our plans in real time in front of our faces when we operate. It is dynamic, so you can see a patient's anatomy in a lot of detail," says Dr. Delaney. "What was interesting the first day that I used it was that it didn't interfere with my surgery or distract me."

Dr. Razzano agrees. "What Mixed Reality means to me is that you're using it intraoperatively in real time. It's not diverting your focus to go look at the computer again," he says.

After his operation with Dr. Razzano, Jeff began to feel improvement in about two weeks. A few months into the rehabilitation process, he noticed a dramatic difference and was able to move his shoulder up and down and back and forth. "Now it slides smooth as silk," Jeff says.

While Jeff continues to use his shoulder thoughtfully, today he is relieved to perform simple tasks like lifting a suitcase and tossing a ball to his son without debilitating pain.

"I'm not trying to throw the ball 90 miles an hour anymore, but if we want to go out and play catch, I know I can do it," he says. "The first time being

able to go out and throw with my son was great for me. But it was even greater for him."

What mixed reality means to me is that you're using it intraoperatively in real time. It's not diverting your focus to go look at the computer again."

Dr. Andrew Razzano

Knee, shoulder and elbow specialist

All surgery carries risk. The only way to determine whether surgery is appropriate for a patient is after consultation with an orthopaedic surgeon regarding risks and benefits of surgery.

Not all patients have the same operative recovery and activity level. Individual results vary.

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