Management's Discussion and Analysis of Financial Condition and Results of
Operations is intended to help the reader understand the results of operations
and the financial condition of Supernus Pharmaceuticals, Inc. (the Company, we,
us, or our). The interim condensed consolidated financial statements included in
this report and this Management's Discussion and Analysis of Financial Condition
and Results of Operations should be read in conjunction with our audited
consolidated financial statements and notes thereto for the year ended
December 31, 2021 and the related Management's Discussion and Analysis of
Financial Condition and Results of Operations, both of which are contained in
our Annual Report on Form 10-K, filed with the Securities and Exchange
Commission on April 13, 2022.

In addition to historical information, this Quarterly Report on Form 10-Q
contains forward-looking statements within the meaning of Section 27A of the
Securities Act of 1933, as amended, and Section 21E of the Securities Exchange
Act of 1934, as amended, which are intended to be covered by the safe harbors
created thereby. These forward-looking statements may include declarations
regarding the Company's belief or current expectations of management, such as
statements including the words "budgeted," "anticipate," "project," "forecast,"
"estimate," "expect," "may," "believe," "potential," and similar statements or
expressions, which are intended to be among the statements that are
forward-looking statements, as such statements reflect the reality of risk and
uncertainty that is inherent in our business. Actual results may differ
materially from those expressed or implied by such forward-looking statements.
Readers are cautioned not to place undue reliance on these forward-looking
statements, which are made as of the date this report was filed with the
Securities and Exchange Commission. Our actual results and the timing of events
could differ materially from those discussed in our forward-looking statements
as a result of many factors, including those set forth under the "Risk Factors"
section of our Annual Report on Form 10-K, our Quarterly Report on Form 10-Q
filed with the Securities and Exchange Commission on August 8, 2022 and
elsewhere in this report as well as in other reports and documents we file with
the Securities and Exchange Commission from time to time. Except as required by
law, we undertake no obligation to update any forward-looking statements to
reflect events or circumstances occurring after the date of this Quarterly
Report on Form 10-Q.

Solely for convenience, in this Quarterly Report on Form 10-Q, the trade names
are referred to without the TM symbols and the trademark registrations are
referred to without the circled R, but such references should not be construed
as any indicator that the Company will not assert, to the fullest extent under
applicable law, our rights thereto.
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Overview



We are a biopharmaceutical company focused on developing and commercializing
products for the treatment of central nervous system (CNS) diseases. Our diverse
neuroscience portfolio includes approved treatments for epilepsy, migraine,
attention-deficit hyperactivity disorder (ADHD), hypomobility in Parkinson's
Disease (PD), cervical dystonia, chronic sialorrhea, dyskinesia in PD patients
receiving levodopa-based therapy, and drug-induced extrapyramidal reactions in
adult patients. The Company is developing a broad range of novel CNS product
candidates including new potential treatments for hypomobility in PD, epilepsy,
depression, and other CNS disorders.

We have a portfolio of commercial products and product candidates.

Commercial Products



•Trokendi XR® (topiramate) is the first once-daily extended-release topiramate
product indicated for the treatment of epilepsy in patients 6 years of age and
older in the United States (U.S.) market. It is also indicated for the
prophylaxis of migraine headache in adults and adolescents 12 years and older.

•Oxtellar XR® (oxcarbazepine) is indicated as therapy for the treatment of partial onset seizures in patients 6 years of age and older. It is also the first once-daily extended-release oxcarbazepine product indicated for the treatment of epilepsy in the U.S.



•Qelbree® (viloxazine extended-release capsules) is a novel non-stimulant
product indicated for the treatment of ADHD in adults and pediatric patients 6
years and older. On April 2, 2021, the U.S. Food and Drug Administration (FDA)
approved Qelbree for the treatment of ADHD in pediatric patients 6 to 17 years
of age. In May 2021, the Company launched Qelbree for pediatric patients in the
U.S. On April 29, 2022, the FDA approved Qelbree for treatment of ADHD in adult
patients. The Company launched Qelbree for adult patients in May 2022.

•GOCOVRI® (amantadine) extended-release capsules is the first and only FDA
approved medicine indicated for the treatment of dyskinesia in patients with PD
receiving levodopa-based therapy, with or without concomitant dopaminergic
medications, and as an adjunctive treatment to levodopa/carbidopa with PD
experiencing "off" episodes.

•APOKYN® (apomorphine hydrochloride injection) is a product indicated for the acute, intermittent treatment of hypomobility, "off" episodes ("end-of-dose wearing off" and unpredictable "on/off" episodes) in patients with advanced PD.

•XADAGO® (safinamide) is a once-daily product indicated as adjunctive treatment to levodopa/carbidopa in patients with PD experiencing "off" episodes.

•Osmolex ER® (amantadine) extended-release is a once-daily product for the treatment of PD and drug-induced extrapyramidal reactions in adult patients.

•MYOBLOC® (rimabotulinumtoxinB injection) is a product indicated for the treatment of cervical dystonia and chronic sialorrhea in adults. It is the only botulinum toxin type B available on the market.


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Research and Development



We are developing a pipeline of novel CNS product candidates for the treatment
of various CNS conditions. The table below summarizes our product candidates in
clinical development.

         Product Candidate                      Indication                     Development                      NDA
                                       Continuous treatment of motor                               Complete Response Letter (CRL)
              SPN-830               fluctuations ("off" episodes) in PD                             received from FDA in October
                                                 patients                                                       2022
              SPN-820                 Treatment-resistant depression             Phase II
              SPN-817                  Treatment-resistant seizures              Phase I
              SPN-443                               CNS                        Preclinical
              SPN-446                               CNS                        Preclinical

SPN-830 (apomorphine infusion device)



SPN-830 is a late-stage drug/device combination product candidate for the
continuous treatment of motor fluctuations ("off" episodes) in PD patients that
are not adequately controlled with oral levodopa and one or more adjunct PD
medications. If approved, it would be the only continuous infusion of
apomorphine available in the U.S. and an important step for PD patients that
would have otherwise been candidates for potentially invasive surgical
procedures, such as deep brain stimulation. Continuous slow infusion may also
limit some of the side effects of a bolus injection of apomorphine.

In December 2021, we resubmitted the NDA to the FDA. In February 2022, we
received a notice from the FDA that the resubmission of the NDA for SPN-830 is
considered as a Standard Review, thereby was assigned a PDUFA target action date
in early October 2022. In October 2022, the FDA issued a CRL regarding the NDA
for SPN-830. The CRL requires additional information and analysis related to the
infusion device and drug product across several areas of the NDA including, but
not limited to, labeling, product quality and manufacturing, device performance
and risk analysis. In addition, the FDA mentions that approval of the NDA
requires inspections that could not be completed in a timely manner due to
COVID-19 travel restrictions. The CRL does not request additional efficacy and
safety clinical studies. The FDA has made an initial determination that the
amendment to the Company's application in response to the CRL will be subject to
a Class 2, or six-month, review timeline.

SPN-820 (NV-5138)



SPN-820 is a first-in-class, orally active small molecule that directly
activates brain mechanistic target of rapamycin complex 1 (mTORC1), a gatekeeper
of cellular metabolism and renewal. SPN-820 binds to and modulates sestrin,
which senses amino acid availability in the brain, a potent natural activator of
mTORC1.

SPN-817 (huperzine A)

SPN-817 represents a novel mechanism of action (MOA) for an anticonvulsant.
SPN-817 is a novel synthetic form of
huperzine A, whose MOA includes potent acetylcholinesterase inhibition, with
pharmacological activities in CNS conditions such as epilepsy. The development
will initially focus on the drug's anticonvulsant activity, which has been shown
in preclinical models to be effective for the treatment of partial seizures and
Dravet Syndrome. SPN-817 is in clinical development and has received Orphan Drug
designation for several epilepsy indications from the FDA.

Adamas Reorganization



In the first quarter of 2022 and subsequent to the Adamas Acquisition, the
Company completed a reorganization of the Adamas legal entities in an effort to
obtain operational, legal and other benefits that also resulted in certain state
tax efficiencies. The reorganization had no effect on the condensed consolidated
financial statements other than certain state tax efficiencies. (See Note 12,
Income Tax (Benefit) Expense).
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COVID-19 Impact



While the impact of the ongoing COVID-19 pandemic did not have a material
adverse effect on our financial position or results of operations for the three
months and nine months ended September 30, 2022, we continue to closely monitor
the events and circumstances surrounding the COVID-19 pandemic and its impact on
all aspects of our business operations. Since the situation surrounding the
COVID-19 pandemic remains fluid and the duration uncertain, the long-term nature
and extent of the impacts of the pandemic on our business operations and
financial position cannot be reasonably estimated at this time. See "Risk
Factors" in Part I, Item 1A of our Annual Report on Form 10-K and "Risk Factors"
in Part II, Item 1A of our Quarterly Report on Form 10-Q filed with the
Securities and Exchange Commission on August 8, 2022 for additional information
on risk factors that could impact our business and our results.

Operational Highlights

Qelbree Launch Update



•Total IQVIA prescriptions were 94,328 in the third quarter of 2022, an increase
of 50% compared to total prescriptions of 62,938 in the second quarter of 2022.
In September 2022, the most recent month available, total prescriptions reached
34,633.

•Qelbree continues to expand its base of prescribers, with approximately 14,265
prescribers in the third quarter of 2022, up from 9,276 prescribers from the
second quarter of 2022.

Product Pipeline Update

SPN-830 (apomorphine infusion device) - Continuous treatment of motor fluctuations ("off" episodes) in Parkinson's disease (PD)



•In October 2022, the Company announced the U.S. Food and Drug Administration
(FDA) issued a Complete Response Letter (CRL) for the SPN-830 New Drug
Application (NDA). The CRL does not request additional efficacy and safety
clinical studies but rather requires additional information and analysis related
to the infusion device and drug product across several areas of the NDA,
including labeling, product quality and manufacturing, device performance and
risk analysis. In addition, the FDA mentions that approval of the NDA requires
inspections that could not be completed in a timely manner due to COVID-19
travel restrictions. Supernus will continue to work closely with the FDA to
address all questions, and when possible, to provide clarity regarding the
potential timing of a resubmission of the NDA. The FDA has made an initial
determination that the amendment to the Company's application in response to the
CRL will be subject to a Class 2, or six-month, review timeline.

SPN-820 - Novel first-in-class activator of mTORC1



•The Phase II multi-center, randomized double-blind placebo-controlled parallel
design study of SPN-820 in adults with treatment-resistant depression is
ongoing. The study will examine the efficacy and safety of SPN-820 over a course
of five weeks of treatment in approximately 270 patients. The primary outcome
measure is the change from baseline to end of treatment period on the
Montgomery-Asberg Depression Rating Scale (MADRS) Total Score, a standard
depression rating scale.

SPN-817 - A novel product candidate for the treatment of epilepsy

•An open-label Phase II clinical study of SPN-817 in patients with treatment-resistant seizures is expected to start in the fourth quarter of 2022.

Critical Accounting Policies and the Use of Estimates



A summary of our significant accounting policies is included in Note 2, Summary
of Significant Accounting Policies of our audited consolidated financial
statements included in the Annual Report on Form 10-K for the year ended
December 31, 2021. There were no significant changes to the disclosures with
respect to our critical accounting policies in our Annual Report on Form 10-K
for the year ended December 31, 2021.
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Results of Operations

Comparison of the Three and Nine Months Ended September 30, 2022 and 2021

Revenues



Revenues consist primarily of net product sales of our commercial products in
the U.S., supplemented by royalty revenues from our collaborative licensing
arrangements. The following table provides information regarding our revenues
during the three and nine months ended September 30, 2022 and 2021 (dollars in
thousands):
                               Three Months Ended September 30,                   Change                    Nine Months Ended September 30,                    Change
                                   2022                2021              Amount            Percent              2022                2021              Amount            Percent
Net product sales
Trokendi XR                    $   69,599          $  80,935          $ (11,336)            (14)%           $  204,033          $ 231,531          $ (27,498)            (12)%
Oxtellar XR                        30,528             29,728                800               3%                88,007             82,120              5,887               7%
GOCOVRI                            27,878                  -             27,878               **                75,179                  -             75,179               **
Qelbree                            18,326              2,370             15,956               **                37,708              2,685             35,023               **
APOKYN                             18,261             24,627             (6,366)            (26)%               57,156             73,338            (16,182)            (22)%
Other(1)                            8,132              7,872                260               3%                23,564             22,867                697               3%
Total net product sales        $  172,724          $ 145,532          $  27,192              19%            $  485,647          $ 412,541          $  73,106              18%
Royalty revenues                    4,629              2,932              1,697              58%                14,263              8,184              6,079              74%
Total revenues                 $  177,353          $ 148,464          $  28,889              19%            $  499,910          $ 420,725          $  79,185              19%

______________________________

(1) Includes net product sales of MYOBLOC, XADAGO and Osmolex ER.



The $27.2 million and 19% increase in net product sales for the three months
ended September 30, 2022, as compared to the same period in 2021, was primarily
due to the inclusion of $27.9 million in net product sales of GOCOVRI,
subsequent to the completion of the Adamas Acquisition in November 2021, as well
as a $16.0 million increase in net product sales of Qelbree, which was launched
in May 2021. Partially offsetting this increase was a $11.3 million decrease in
net product sales of Trokendi XR and a $6.4 million decrease in net product
sales of APOKYN primarily attributable to the decline in unit demand due to
competitive headwinds.

The $73.1 million and 18% increase in net product sales for the nine months
ended September 30, 2022, as compared to the same period in 2021, was primarily
due to the inclusion of $75.2 million in net product sales of GOCOVRI,
subsequent to the completion of the Adamas Acquisition in November 2021, the
increase of $5.9 million in net product sales of Oxtellar, as well as a $35.0
million increase in net product sales of Qelbree, which was launched in May 2021
for pediatric patients and in May 2022 for adult patients. Partially offsetting
this increase was a $27.5 million decrease in net product sales of Trokendi XR
and a $16.2 million decrease in net product sales of APOKYN primarily
attributable to the decline in unit demand due to competitive headwinds.

Sales Deductions and Related Accruals



We record accrued product returns and accrued product rebates as current
liabilities in Accrued product returns and rebates, on our condensed
consolidated balance sheets. We record sales discounts as a reduction against
Accounts receivable, net on the condensed consolidated balance sheets. Both
amounts are generally affected by changes in gross product sales, changes in the
provision for net product sales deductions, and the timing of payments/credits.





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The following table provides a summary of activity with respect to sales
deductions and related accruals during the periods indicated (dollars in
thousands):

                                                   Accrued Product Returns and
                                                             Rebates
                                                                                        Reduction to Accounts
                                                    Product            Product              Receivable for
                                                    Returns            Rebates             Sales Discounts              Total
Balance at December 31, 2021                     $   35,127          $  97,597          $            13,537          $ 146,261

Provision


Provision for current year sales                     13,846            321,860                       55,693            391,399
Adjustments relating to prior year sales             (3,225)                31                           (3)            (3,197)
Total provision                                  $   10,621          $ 321,891          $            55,690          $ 388,202
Less: Actual payments/credits                        (6,440)          (300,326)                     (56,447)          (363,213)
Balance at September 30, 2022                    $   39,308          $ 119,162          $            12,780          $ 171,250

Balance at December 31, 2020                     $   29,603          $  96,589          $            11,404          $ 137,596

Provision


Provision for current year sales                      9,945            275,352                       51,472            336,769
Adjustments relating to prior year sales             (1,525)             1,334                           19               (172)
Total provision                                  $    8,420          $ 276,686          $            51,491          $ 336,597
Less: Actual payments/credits                        (4,611)          (274,639)                     (51,677)          (330,927)
Balance at September 30, 2021                    $   33,412          $  98,636          $            11,218          $ 143,266

Accrued Product Returns and Rebates Balances



The accrued product returns balance increased from $33.4 million as of
September 30, 2021 to $39.3 million as of September 30, 2022 principally due to
the timing of related return activity and an increase in provision for product
returns primarily for Qelbree.

The accrued product rebates balance increased from $98.6 million as of September 30, 2021 to $119.2 million as of September 30, 2022 due to timing of payments which more than offsets the increase in the provision.

Provision for Product Returns and Rebates



The provision for product returns increased from $8.4 million for the nine month
period ended September 30, 2021 to $10.6 million for the nine month period ended
September 30, 2022. The change was primarily attributable to an increase in
volume of products sold with the launch of Qelbree for pediatric patients in the
second quarter of 2021 and for adults in second quarter of 2022, partially
offset by lower sales of Trokendi XR.

The provision for product rebates increased from $276.7 million for the nine month period ended September 30, 2021 to $321.9 million for the nine month period ended September 30, 2022. The increase was primarily attributable to higher sales volume, as well as higher per patient payments under both government and commercial managed care programs.

Royalty Revenues



Royalty revenues include a royalty from net product sales of Mydayis, a product
of Takeda Pharmaceuticals Company Ltd., Namzaric royalties, and noncash royalty
revenue pursuant to our agreement with Healthcare Royalty Partners III, L.P. (HC
Royalty). HC Royalty receives royalty payments from United Therapeutics
Corporation (United Therapeutics) based on net product sales of United
Therapeutics' product Orenitram.

Royalty revenues were $4.6 million and $2.9 million for the three months ended
September 30, 2022 and 2021, respectively. Royalty revenues were $14.3 million
and $8.2 million for the nine months ended September 30, 2022 and 2021,
respectively. The increase was primarily due to the Namzaric royalties for the
three and nine months ended September 30, 2022. Namzaric royalty rights were
acquired in connection with the Adamas Acquisition.
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Cost of Goods Sold



Cost of goods sold was $25.9 million and $18.1 million for the three months
ended September 30, 2022 and 2021, respectively. The increase was primarily due
to higher Qelbree sales, offset by lower royalty expense compared to the same
period in the prior year.

Cost of goods sold was $64.3 million and $58.1 million for the nine months ended
September 30, 2022 and 2021, respectively. The increase was primarily due to
higher Qelbree sales, offset by lower royalty expense compared to the same
period in the prior year.

Royalty expense associated with the acquired commercial products, APOKYN and
XADAGO, made up the majority of cost of goods sold. Royalty expense declined
$2.4 million for the three months ended September 30, 2022 and $5.7 million for
the nine months ended September 30, 2022 primarily due to the decline in APOKYN
sales in 2022.

Research and Development Expenses



R&D expenses were $19.6 million and $19.7 million for the three months ended
September 30, 2022 and 2021, respectively. R&D expenses were $56.8 million and
$69.4 million for the nine months ended September 30, 2022 and 2021. The $12.6
million decrease for the nine months ended September 30, 2022 was primarily due
to the write-down of the $15.0 million investment in Navitor LLC which was
attributable to a single in-process research and development (IPR&D) asset and
recorded in R&D expense in the first quarter of 2021, offset by a $2.0 million
increase in costs associated with regulatory activities mainly related to
acquired products.

Selling, General and Administrative Expenses



The following table provides information regarding our selling, general and
administrative (SG&A) expenses during the periods indicated (dollars in
thousands):

                                     Three Months Ended September
                                                  30,                                 Change                    Nine Months Ended September 30,                     Change
                                        2022               2021             Amount             Percent              2022                2021              Amount             Percent
 Selling and marketing              $   85,704          $ 50,704          $ 35,000               69%            $  219,798          $ 137,531          $  82,267               60%
 General and administrative             26,610            21,328             5,282               25%                83,451             65,493          $  17,958               27%
 Total                              $  112,314          $ 72,032          $ 40,282               56%            $  303,249          $ 203,024          $ 100,225               49%


Selling, general and administrative expenses increased by 56% to $112.3 million
for the three months ended September 30, 2022. The increase was primarily due to
increased marketing expenditures of approximately $30.5 million primarily for
activities to support the launch of Qelbree to the adult population and the
Qelbree direct-to-consumer campaign, which substantially occurred in the third
quarter of 2022, as well as the acquired commercial products from Adamas
Acquisition. In addition, general and administrative expenses increased
$3.3 million due to higher professional and consulting costs and increased
employee-related costs mainly to support IT and finance operations related to
the ransomware incident, financial reporting and Adamas integration in 2022.

Selling, general and administrative expenses increased by 49% to $303.2 million
for the nine months ended September 30, 2022. The increase was primarily due to
increased marketing expenditures of (i) approximately $46.1 million primarily
for activities to support the launch of Qelbree to the adult population and the
Qelbree direct-to-consumer campaign, which substantially occurred in the third
quarter of 2022, as well as (ii) approximately $8.0 million related to the
commercial products acquired from the Adamas Acquisition. In addition, general
and administrative expenses increased $10.7 million due to higher professional
and consulting costs and increased employee-related costs mainly to support IT
and finance operations related to the ransomware incident, financial reporting
and Adamas integration in 2022.

Amortization of Intangible Assets



Amortization of intangible assets was $20.6 million and $6.0 million for the
three months ended September 30, 2022 and 2021, respectively. Amortization of
intangible assets was $61.9 million and $18.0 million for the nine months ended
September 30, 2022 and 2021, respectively. The increase was due to amortization
of the definite-lived intangible assets acquired in the Adamas Acquisition.

Contingent Consideration Expense (Gain)


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The change in fair value of the contingent consideration liabilities was an expense of $0.5 million and $0.1 million for the three months ended September 30, 2022 and 2021, respectively. The contingent consideration expense was primarily due to an increase in the estimated fair value of regulatory and developmental milestones due to the passage of time.



The change in fair value of the contingent consideration liabilities was an
expense of $1.9 million and a gain of $7.7 million for the nine months ended
September 30, 2022 and 2021, respectively. The contingent consideration gain was
primarily due to a reduction of the sales based contingent consideration
liabilities associated with the USWM Acquisition recorded in the second quarter
of 2021, offset by an increase in the estimated fair value of regulatory and
developmental milestones due to the passage of time and the accretion to the
payout amount related to the milestone achieved in the first quarter of 2022.

Other Income (Expense)



Other income (expense) was income of $1.1 million and an expense of $3.6 million
for the three months ended September 30, 2022 and 2021, respectively. The
increase in other income was principally due to a decrease of $4.2 million in
interest expense. The decrease in interest expense was primarily related to the
Company's adoption of ASU 2020-06 on January 1, 2022. As a result of the
adoption, the Company no longer records interest expense on the previously
recorded discount for the embedded conversion feature on the 2023 Notes.

Other income (expense) was income of $13.8 million and an expense of $8.8
million for the nine months ended September 30, 2022 and 2021, respectively. The
increase in other income was primarily due to $12.9 million recognized in
connection with the gain associated with the Navitor investment and a decrease
in interest expense of $12.0 million primarily related to the Company's adoption
of ASU 2020-06.

Income Tax (Benefit) Expense

Income tax benefit was $2.2 million and income tax expense was $7.4 million for
the three months ended September 30, 2022 and 2021, respectively. The decrease
was mainly due to lower earnings before income taxes. The effective income tax
rate was 493.9% and 25.5% for the three months ended September 30, 2022 and
2021, respectively. The change in effective income tax rate was primarily due to
larger excess tax benefits of stock-based awards in 2022.

Income tax benefit was $9.6 million and income tax expense was $20.1 million for
the nine months ended September 30, 2022 and 2021, respectively. The effective
income tax rate was (37.6)% and 28.3% for the nine months ended September 30,
2022 and 2021, respectively. The change in income tax (benefit) expense and
effective income tax rate was primarily due to tax benefits associated with the
Adamas legal entities reorganization in the first quarter of 2022.

Liquidity and Capital Resources



We have financed our operations primarily with cash generated from product
sales, supplemented by revenues from royalty and licensing arrangements, as well
as proceeds from the sale of equity and debt securities. Continued cash
generation is highly dependent on the success of our commercial products, as
well as the success of our product candidates if approved by the FDA. While we
expect continued profitability in future years, we anticipate there may be
significant variability from year to year in the level of our profits
particularly due to the commercial launch of Qelbree and the future commercial
launch of SPN-830 (apomorphine infusion device), if approved by the FDA;
continued market and payor pressures for our commercial products; and the likely
unfavorable impact of the upcoming loss of patent exclusivity for Trokendi XR in
January 2023, or sooner under certain conditions.

The Company believes its balances of cash, cash equivalents and unrestricted
marketable securities, which totaled $523.7 million as of September 30, 2022,
along with cash generated from ongoing operations and continued access to debt
markets, will be sufficient to satisfy its cash requirements over the next 12
months and beyond.

We may, from time to time, consider raising additional capital through: new
collaborative arrangements; strategic alliances; additional equity and/or debt
financings; or financing from other sources, especially in conjunction with
opportunistic business development initiatives. We will continue to actively
manage our capital structure and to consider all financing opportunities that
could strengthen our long-term financial profile. Any such capital raises may or
may not be similar to transactions in which we have engaged in the past. There
can be no assurance that any such financing opportunities will be available on
acceptable terms, if at all.
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Financial Condition



Cash and cash equivalents, marketable securities, and long-term marketable
securities as of the periods presented below, are as follows (dollars in
thousands):

                                     September 30,       December 31,                Change
                                          2022               2021            Amount         Percent
  Cash and cash equivalents         $      111,492      $     203,434      $ (91,942)        (45)%
  Marketable securities                    280,297            136,246        144,051         106%
  Long-term marketable securities          131,937            119,166         12,771          11%
  Total                             $      523,726      $     458,846      $  64,880          14%

Total cash and cash equivalents, marketable securities and long-term marketable securities increased by $64.9 million in the first nine months of 2022, primarily due to cash generated from ongoing operations.



As of September 30, 2022 and December 31, 2021, the outstanding principal on our
0.625% Convertible Senior Notes Due 2023 (2023 Notes) was $402.5 million. No
2023 Notes have been converted as of September 30, 2022. We have reclassified
the debt from long-term to current liabilities on our Condensed Consolidated
Balance Sheet, as the debt matures in less than twelve months as of
September 30, 2022. There were no changes to the separate convertible note hedge
transactions (collectively, the Convertible Note Hedge Transactions) and
separate warrant transactions (the Warrant Transactions). Refer to Part I, Item
1, Unaudited Condensed Financial Statements, Note 9, Convertible Senior Notes
Due 2023, in the Notes to the Condensed Consolidated Financial Statements, for
further discussion of the 2023 Notes and our other indebtedness.

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