Surrozen, Inc. announced that data from its liver disease program, including preclinical studies of SZN-043 showing improved liver metabolic function, were presented during The Liver Meeting 2021, organized by the American Association for the Study of Liver Diseases (AASLD) and held November 12-15. In a poster titled, ?SZN-043 Improves Liver Metabolic Function in a Mouse Preclinical Model,? the data showed that methacetin quantification after IV dosing in mice can be used to demonstrate that SZN-043 can quickly increase liver function and that the duration of this effect is transient but can last beyond effects on gene regulation. The poster titled ?Non-Invasive Pharmacodynamic Markers of SZN-043 Target Engagement and Wnt Pathway Activation,? analyzed the effect of SZN-043 on non-invasive pharmacodynamic markers of target occupancy and Wnt/?-catenin activation in normal mice treated with a single dose of SZN-043 at increasing doses. Target occupancy was evaluated by measuring serum alkaline phosphatase (ALP) as SZN-043 binds to the ASGR receptor and increases ALP serum concentration by interfering with ALP elimination occurring through the ASGR receptor. Wnt/?-catenin activation was evaluated by measuring serum leukocyte cell-derived chemotaxin-2 (LECT2), a direct Wnt target gene. The results showed that serum ALP concentrations and LECT2 concentrations increased in a dose-dependent manner and that these markers can be used as non-invasive pharmacodynamic markers of SZN-043 target occupancy and Wnt activation, respectively. Consistent with the observation of interfering with ALP elimination, SZN-043 did not affect ALP gene expression.