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Takeda to Acquire Adaptate Biotherapeutics to Develop Novel Gamma Delta T Cell Engager Therapies Targeting Solid Tumors

01/11/2022 | 10:03am EDT

OSAKA, Japan, and LONDON, UK. - Takeda Pharmaceutical Company Limited (TSE:4502/NYSE:TAK) ('Takeda') announced the exercise of its option to acquire Adaptate Biotherapeutics ('Adaptate'), a UK company focused on developing antibody-based therapeutics for the modulation of variable delta 1 (V?1) gamma delta (??) T cells. Through the acquisition, Takeda will obtain Adaptate's antibody-based T cell engager platform, including pre-clinical candidate and discovery pipeline programs. Adaptate's T cell engagers are designed to specifically modulate T cell-mediated immune responses at tumor sites while sparing damage to healthy cells.

The planned acquisition of Adaptate follows Takeda's recently exercised option to acquire GammaDelta Therapeutics ('GammaDelta') and is intended to further accelerate the development of innovative T cell-based therapies. Combining GammaDelta's cell therapy-based platform and Adaptate's antibody-based T cell engager platform with Takeda's strong research and development organization positions Takeda to be at the leading edge in deploying the full potential of T cells in the fight against cancer. The planned acquisition complements Takeda's ongoing efforts to research and develop cell engagers for solid tumor applications, bolstered by the novel T cell engager COBRA platform, which was acquired from Maverick Therapeutics in another successful build-to-buy collaboration.

'Partnering with early-stage innovators to access cutting-edge platforms in the fight against cancer is at the center of our R&D strategy,' said Christopher Arendt, Ph.D., Head of Oncology Cell Therapy and Therapeutic Area Unit of Takeda. 'Adaptate's T cell engager platform and the team's deep understanding of T cell biology gives us an opportunity to develop a new class of therapeutics that tap into powerful innate immune mechanisms. The planned acquisition will strengthen our immuno-oncology R&D efforts as part of our ongoing pursuit of life-transforming medicines for patients with cancer.'

Adaptate was formed in 2019 as a spin-out company from GammaDelta with investment from Abingworth LLP and Takeda, in which Takeda received an exclusive right to purchase Adaptate for a pre-negotiated upfront payment. The acquisitions of Adaptate and GammaDelta are expected to be finalized in Q1 of Takeda's fiscal year 2022, pending completion of review under applicable antitrust laws, including the Hart-Scott-Rodino (HSR) Antitrust Improvements Act of 1976 in the U.S.

'Our acquisition by Takeda recognizes the tremendous work put in over the last two years by Adaptate's incredibly talented team,' said Dr. Natalie Mount, CEO of Adaptate. 'We have rapidly demonstrated, in preclinical models, the therapeutic potential of our novel V?1-targeting antibodies, and this move brings us an exciting step closer to realizing the full potential for V?1 T cell targeted therapies to improve treatment outcomes for cancer patients.'

In addition, Tim Haines, Chair & Managing Partner at Abingworth noted, 'Having played an instrumental role in creating Adaptate, we are delighted to see the impressive developments of its T cell therapeutic antibody portfolio to date, under the leadership of Natalie Mount. We look forward to seeing Takeda progress Adaptate's very promising therapeutic antibodies into the clinic.'

Takeda's oncology pipeline focuses on novel strategies that leverage the power of the immune system, with a focus on innate immunity. Innate immune responses serve as the body's first defense mechanism against disease and involve the orchestration of a broad arsenal of mechanisms and cell types, including T cells and natural killer (NK) cells, that may help to overcome cancer's ability to evade immune recognition. Adaptate has discovered a unique set of antibodies that selectively modulate T cell activity in the tumor microenvironment. The antibodies provide a precisely targeted signal to the immune system, thereby offering the opportunity for superior efficacy and safety compared to conventional immuno-oncology approaches in solid tumors.

Takeda's Commitment to Oncology

Our core R&D mission is to deliver novel medicines to patients with cancer worldwide through our commitment to science, breakthrough innovation and passion for improving the lives of patients. Whether it's with our hematology therapies, our robust pipeline, or solid tumor medicines, we aim to stay both innovative and competitive to bring patients the treatments they need. For more information, visit www.takedaoncology.com

About Takeda Pharmaceutical Company Limited

Takeda Pharmaceutical Company Limited (TSE: 4502/NYSE: TAK) is a global, values-based, R&D-driven biopharmaceutical leader headquartered in Japan, committed to discover and deliver life-transforming treatments, guided by our commitment to patients, our people and the planet. Takeda focuses its R&D efforts on four therapeutic areas: Oncology, Rare Genetics and Hematology, Neuroscience, and Gastroenterology (GI). We also make targeted R&D investments in Plasma-Derived Therapies and Vaccines. We are focusing on developing highly innovative medicines that contribute to making a difference in people's lives by advancing the frontier of new treatment options and leveraging our enhanced collaborative R&D engine and capabilities to create a robust, modality-diverse pipeline. Our employees are committed to improving quality of life for patients and to working with our partners in healthcare in approximately 80 countries and regions.

Important Notice

For the purposes of this notice, 'press release' means this document, any oral presentation, any question-and-answer session and any written or oral material discussed or distributed by Takeda Pharmaceutical Company Limited ('Takeda') regarding this release. This press release (including any oral briefing and any question-and-answer in connection with it) is not intended to, and does not constitute, represent or form part of any offer, invitation or solicitation of any offer to purchase, otherwise acquire, subscribe for, exchange, sell or otherwise dispose of, any securities or the solicitation of any vote or approval in any jurisdiction. No shares or other securities are being offered to the public by means of this press release. No offering of securities shall be made in the United States except pursuant to registration under the U.S. Securities Act of 1933, as amended, or an exemption therefrom. This press release is being given (together with any further information which may be provided to the recipient) on the condition that it is for use by the recipient for information purposes only (and not for the evaluation of any investment, acquisition, disposal or any other transaction). Any failure to comply with these restrictions may constitute a violation of applicable securities laws.

The companies in which Takeda directly and indirectly owns investments are separate entities. In this press release, 'Takeda' is sometimes used for convenience where references are made to Takeda and its subsidiaries in general. Likewise, the words 'we', 'us' and 'our' are also used to refer to subsidiaries in general or to those who work for them. These expressions are also used where no useful purpose is served by identifying the particular company or companies.

Takeda Forward-Looking Statements

This press release and any materials distributed in connection with this press release may contain forward-looking statements, beliefs or opinions regarding Takeda's future business, future position and results of operations, including estimates, forecasts, targets and plans for Takeda. Without limitation, forward-looking statements often include words such as 'targets', 'plans', 'believes', 'hopes', 'continues', 'expects', 'aims', 'intends', 'ensures', 'will', 'may', 'should', 'would', 'could' 'anticipates', 'estimates', 'projects' or similar expressions or the negative thereof. These forward-looking statements are based on assumptions about many important factors, including the following, which could cause actual results to differ materially from those expressed or implied by

the forward-looking statements: the economic circumstances surrounding Takeda's global business, including general economic conditions in Japan and the United States; competitive pressures and developments; changes to applicable laws and regulations, including global health care reforms; challenges inherent in new product development, including uncertainty of clinical success and decisions of regulatory authorities and the timing thereof; uncertainty of commercial success for new and existing products; manufacturing difficulties or delays; fluctuations in interest and currency exchange rates; claims or concerns regarding the safety or efficacy of marketed products or product candidates; the impact of health crises, like the novel coronavirus pandemic, on Takeda and its customers and suppliers, including foreign governments in countries in which Takeda operates, or on other facets of its business; the timing and impact of post-merger integration efforts with acquired companies; the ability to divest assets that are not core to Takeda's operations and the timing of any such divestment(s); and other factors identified in Takeda's most recent Annual Report on Form 20-F and Takeda's other reports filed with the U.S. Securities and Exchange Commission, available on Takeda's website at: https://www.takeda.com/investors/reports/sec-filings/ or at www.sec.gov. Takeda does not undertake to update any of the forward-looking statements contained in this press release or any other forward-looking statements it may make, except as required by law or stock exchange rule. Past performance is not an indicator of future results and the results or statements of Takeda in this press release may not be indicative of, and are not an estimate, forecast, guarantee or projection of Takeda's future results.

About Adaptate Biotherapeutics

Adaptate Biotherapeutics is an immunotherapy company developing an innovative portfolio of therapeutic antibodies designed to modulate the activity of a patient's own cytotoxic gamma delta T cells in situ. Our exquisitely targeted approach offers the potential to safely and effectively address the challenges often encountered by current cancer immunotherapies.

Adaptate Biotherapeutics spun-out from GammaDelta Therapeutics in late 2019. The Company has received investment from Abingworth LLP and Takeda Pharmaceutical Company Limited with support from King's College London, the Francis Crick Institute and Cancer Research Technology.


Takeda Media

Japanese Media

Ritsuko Nomura

E: ritsuko.nomura@takeda.com

T: +81 (0) 466-32-4520

U.S. and International Media

David Webster

E: david.webster@takeda.com

T: +1 (617) 551-7929

Adaptate Contacts

Sarah Jeffery

Zyme Communications

E: sarah.jeffery@zymecommunications.com

T: +44 (0) 7771 730 919

(C) 2022 Electronic News Publishing, source ENP Newswire

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