On December 14, 2020, Tetraphase Pharmaceuticals, Inc. entered into a Termination of Lease and Voluntary Surrender of Premises Agreement (the “Lease Termination Agreement”) with ARE-480 Arsenal Street, LLC (the “Landlord”) for its office and laboratory space at 480 Arsenal Way, Watertown, Massachusetts (the “Watertown Lease”). The Lease Termination Agreement is effective December 31, 2020. In connection with the Lease Termination Agreement, La Jolla will pay the Landlord approximately $0.5 million and will otherwise have no further obligations under the Watertown Lease, including with respect to the estimated remaining $3.3 million of future lease payments.