Reference is made throughout this Management's Discussion and Analysis of
Financial Condition and Results of Operations to Notes to the   Consolidated
Financial Statements  , which begin on page F-1 of this report. Management's
discussion and analysis of financial condition and results of operations for
2019 is included in Item 7 of the company's 2020   Annual Report on Form 10-K
filed with the Securities and Exchange Commission.

The company refers to various amounts or measures not prepared in accordance
with generally accepted accounting principles (non-GAAP measures). These
non-GAAP measures are further described and reconciled to their most directly
comparable amount or measure under the section "  N    on-GAAP

M easures " later in this "Management's Discussion and Analysis of Financial Condition and Results of Operations"

Overview

Thermo Fisher Scientific Inc. enables customers to make the world healthier,
cleaner and safer by helping them accelerate life sciences research, solve
complex analytical challenges, improve patient diagnostics and therapies, and
increase laboratory productivity. Markets served include pharmaceutical and
biotech, academic and government, industrial and applied, as well as healthcare
and diagnostics. The company's operations fall into four segments (Note 4): Life
Sciences Solutions, Analytical Instruments, Specialty Diagnostics and Laboratory
Products and Biopharma Services.

Financial Highlights - 2021 Compared With 2020



(Dollars in millions except per share amounts)                       2021              2020               Change
Revenues                                                      $ 39,211          $ 32,218                 22    %
GAAP operating income                                         $ 10,028          $  7,794                 29    %
GAAP operating income margin                                      25.6  %           24.2  %             1.4   pt
Adjusted operating income (non-GAAP measure)                  $ 12,138          $  9,556                 27    %
Adjusted operating income margin (non-GAAP measure)               31.0  %           29.7  %             1.3   pt

GAAP diluted earnings per share attributable to Thermo Fisher Scientific Inc.

$  19.46          $  15.96                 22    %
Adjusted earnings per share (non-GAAP measure)                $  25.13          $  19.56                 28    %


Organic Revenue Growth

Revenue growth                                    22  %
Impact of acquisitions                             3  %
Impact of currency translation                     2  %

Organic revenue growth* (non-GAAP measure) 17 %

* Results may not sum due to rounding.



The company mobilized in early 2020 to support the COVID-19 pandemic response
with products and services that help analyze, diagnose and protect from the
virus. However, as a result of the pandemic's impact on various markets, the
company saw a significant reduction in customer activity in several businesses
by late March 2020 that materially adversely affected primarily the 2020 results
of the Analytical Instruments segment and, to a lesser extent, some businesses
within the company's other three segments. The negative impact significantly
lessened in 2021, but could worsen in 2022 dependent on the success of global
efforts to control and unwind from the pandemic and economic activity ramping
up. During 2021, the Life Sciences Solutions and Specialty Diagnostics segments
as well as the laboratory products business continued to support COVID-19
diagnostic testing, scaling and evolving their molecular diagnostics solutions
and plastic consumables businesses to respond to the on-going COVID-19 pandemic.
The biosciences and bioproduction businesses also expanded their capacity to
meet the needs of pharma and biotech customers as they rapidly expanded their
own production volumes to meet global vaccine manufacturing requirements.
Additionally, through our pharma services business, we provided our pharma and
biotech customers with the services they needed to develop and produce vaccines
and therapies globally. While these positive impacts are expected to continue
through 2022, the duration and extent of future revenues from such sales are
uncertain and dependent primarily on customer testing as well as therapy and
vaccine demand. Sales of products related to COVID-19 response were $9.23
billion and $6.63 billion in 2021 and 2020, respectively.

Conditions were strong in each of the company's end markets during 2021.
Revenues were particularly strong in pharma and biotech driven by strong market
dynamics and the company's role in supporting customers across a wide range of
therapeutic areas, including our role in supporting COVID-19 vaccines and
therapies. Customers in the academic and

                                       26

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                         THERMO FISHER SCIENTIFIC INC.
          MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
                           AND RESULTS OF OPERATIONS

Overview (continued)



government market increased demand as a result of positive funding trends around
the globe and a return to pre-pandemic levels of activity. Customer activity in
the industrial and applied market returned to pre-pandemic levels in 2021.
Revenues from customers in the diagnostics and healthcare market were driven by
growth in COVID-19 testing-related products as the company continued to support
the societal response to the pandemic. Sales growth was strong across all
geographic regions during 2021. The company continues to execute its proven
growth strategy which consists of three pillars:

•Developing high-impact, innovative new products,

•Leveraging our scale in high-growth and emerging markets, and

•Delivering a unique value proposition to our customers.



GAAP operating income margin and adjusted operating income margin increased in
2021 due primarily to profit on higher sales and sales mix, offset in part by
strategic growth investments to support the company's near and long-term growth.

The company's references to strategic growth investments generally refer to
targeted spending for enhancing commercial capabilities, including expansion of
geographic sales reach and e-commerce platforms, marketing initiatives, expanded
service and operational infrastructure, research and development projects and
other expenditures to enhance the customer experience, as well as incentive
compensation and recognition for employees. The company's references throughout
this discussion to productivity improvements generally refer to improved cost
efficiencies from its Practical Process Improvement (PPI) business system
including reduced costs resulting from implementing continuous improvement
methodologies, global sourcing initiatives, a lower cost structure following
restructuring actions, including headcount reductions and consolidation of
facilities, and low cost region manufacturing. Productivity improvements are
calculated net of inflationary cost increases.

Notable Recent Acquisitions



On January 15, 2021, the company acquired, within the Laboratory Products and
Biopharma Services segment, the Belgium-based European viral vector
manufacturing business of Groupe Novasep SAS for $830 million in net cash
consideration. The European viral vector manufacturing business provides
manufacturing services for vaccines and therapies to biotechnology companies and
large biopharma customers. The acquisition expands the segment's capabilities
for cell and gene vaccines and therapies.

On February 25, 2021, the company acquired, within the Life Sciences Solutions
segment, Mesa Biotech, Inc., a U.S.-based molecular diagnostic company, for $407
million in net cash consideration and contingent consideration with an initial
fair value of $65 million due upon the completion of certain milestones. Mesa
Biotech has developed and commercialized a PCR based rapid point-of-care testing
platform available for detecting infectious diseases including COVID-19. The
acquisition enables the company to accelerate the availability of reliable and
accurate advanced molecular diagnostics at the point of care.

On September 30, 2021, the company assumed operating responsibility, within the
Laboratory Products and Biopharma Services segment, of a new state-of-the-art
biologics manufacturing facility in Lengnau, Switzerland from CSL Limited to
perform pharma services for CSL with capacity to serve other customers as well.
The company expects to make fixed lease payments aggregating to $555 million
(excluding renewals) from 2021 to 2041, with additional amounts dependent on the
extent of revenues from customers of the facility other than CSL.

On December 8, 2021, the company acquired, within the Laboratory Products and
Biopharma Services segment, PPD, Inc., a U.S.-based global provider of clinical
research services to the pharma and biotech industry, for $15.99 billion in net
cash consideration and $43 million of equity awards exchanged. The addition of
PPD's clinical research services enhances our offering to biotech and pharma
customers by enabling them to accelerate innovation and increase their
productivity within the drug development process. In 2020, PPD generated
revenues of $4.68 billion.

On December 30, 2021, the company acquired, within the Life Sciences Solutions
segment, PeproTech, Inc., a U.S. based developer and manufacturer of recombinant
proteins, for $1.86 billion in net cash consideration. PeproTech provides
bioscience reagents known as recombinant proteins, including cytokines and
growth factors. The acquisition expands the segment's bioscience offerings.

Results of Operations



The company's management evaluates segment operating performance using operating
income before certain charges/credits as defined in Note 4. Accordingly, the
following segment data are reported on this basis.

                                       27

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                         THERMO FISHER SCIENTIFIC INC.
          MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
                           AND RESULTS OF OPERATIONS

Results of Operations (continued)



(Dollars in millions)                                  2021          2020
Revenues
Life Sciences Solutions                          $ 15,631      $ 12,168
Analytical Instruments                              6,069         5,124
Specialty Diagnostics                               5,659         5,343
Laboratory Products and Biopharma Services         14,862        12,245
Eliminations                                       (3,010)       (2,662)
Consolidated revenues                            $ 39,211      $ 32,218




Life Sciences Solutions                                                                                                                                Organic*
                                                                            Total                  Currency               Acquisitions/               (non-GAAP
(Dollars in millions)               2021              2020                 Change               Translation                Divestitures                measure)
Revenues                     $ 15,631          $ 12,168                     28  %                      2  %                        3  %                   23  %
Segment income               $  7,817          $  6,109                     28  %
Segment income margin            50.0  %           50.2  %                -0.2 pt

* Results may not sum due to rounding



The increase in segment revenues at existing businesses in 2021 was driven by a
combination of increased demand for testing to diagnose COVID-19 with higher
sales of biosciences products and strong demand in each of the segment's
businesses. The decrease in segment income margin resulted primarily from
strategic growth investments, offset in part by profit on higher sales.


Analytical Instruments                                                                                                                                Organic*
                                                                           Total                  Currency               Acquisitions/               (non-GAAP
(Dollars in millions)               2021              2020                Change               Translation                Divestitures                measure)
Revenues                     $  6,069          $  5,124                    18  %                      2  %                        -  %                   17  %
Segment income                  1,197               808                    48  %
Segment income margin            19.7  %           15.8  %                3.9 pt

* Results may not sum due to rounding



The increase in segment revenues at existing businesses in 2021 was due to
increased demand for products sold by each of the segment's primary businesses
with particular strength in electron microscopy instruments as well as
chromatography and mass spectrometry instruments. The increase in segment income
margin was primarily due to profit on higher sales and, to a lesser extent, a
$108 million charge in 2020 related to a long-term supply contract (discussed in
Note 12), offset in part by strategic growth investments.


Specialty Diagnostics                                                                                                                                  Organic*
                                                                            Total                  Currency               Acquisitions/               (non-GAAP
(Dollars in millions)               2021              2020                 Change               Translation                Divestitures                measure)
Revenues                     $  5,659          $  5,343                      6  %                      1  %                        -  %                    5  %
Segment income                  1,280             1,368                     (6) %
Segment income margin            22.6  %           25.6  %                -3.0 pt

* Results may not sum due to rounding



The increase in segment revenues at existing businesses in 2021 was due to
higher demand primarily driven by products addressing treatment of COVID-19,
with particular strength in sales of products sold through the segment's
healthcare market channel, immunodiagnostics and clinical diagnostics products.
The decrease in segment income margin was primarily due to sales mix and
strategic investments, offset in part by profit on higher sales and, to a lesser
extent, a $13 million credit to cost of product revenue as a result of changing
the method of accounting for inventories (discussed in Note 1).

                                       28

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                         THERMO FISHER SCIENTIFIC INC.
          MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
                           AND RESULTS OF OPERATIONS

Results of Operations (continued)




Laboratory Products and Biopharma Services                                                                                                            Organic*
                                                                           Total                  Currency               Acquisitions/               (non-GAAP
(Dollars in millions)               2021              2020                Change               Translation                Divestitures                measure)
Revenues                     $ 14,862          $ 12,245                    21  %                      2  %                        5  %                   15  %
Segment income                  1,844             1,271                    45  %
Segment income margin            12.4  %           10.4  %                2.0 pt

* Results may not sum due to rounding



The increase in segment revenues at existing businesses in 2021 was primarily
due to increased demand in each of the segment's principal businesses with
particular strength in products sold through its pharma services business and
research and safety market channel and, to a lesser extent, laboratory products
businesses. The increase in segment income margin was primarily due to profit on
higher sales and sales mix, and, to a lesser extent, acquisitions and a
$20 million credit to cost of product revenue as a result of changing the method
of accounting for inventories (discussed in Note 1), offset in part by strategic
growth investments.

Non-operating Items

(Dollars in millions)                                        2021        2020
Net interest expense                                     $ 493       $ 488
GAAP other income/(expense)                               (694)        (76)

Adjusted other income/(expense) (non-GAAP measure) 38 45 GAAP tax rate

                                             12.5  %     11.8  %
Adjusted tax rate (non-GAAP measure)                      14.6  %     14.3  %



Net interest expense (interest expense less interest income) increased due primarily to the increase in debt to finance the acquisition of PPD and for general corporate purposes, offset in part by lower average interest rates. See additional discussion under the caption "Liquidity and Capital Resources" below.



GAAP other income/(expense) and adjusted other income/(expense) includes
currency transaction gains and losses on non-operating monetary assets and
liabilities and net periodic pension benefit cost/income, excluding the service
cost component. GAAP other income/(expense) in 2021 also includes $767 million
of losses on the early extinguishment of debt (Note 10) and $36 million of
financing costs associated with obtaining bridge financing commitments in
connection with the agreement to acquire PPD (Note 2), offset in part by $66
million of net gains on investments. GAAP other income/(expense) in 2020
includes $81 million of financing costs for a terminated acquisition, primarily
for loan commitment fees and entering into hedging contracts and $42 million of
expense reclassified from accumulated other comprehensive items related to a
hedge arrangement (Note 14), offset in part by $10 million of net gains on
investments.

The company's GAAP and adjusted tax rates increased in 2021 compared to 2020,
primarily due to higher profits at different marginal rates, offset in part by
the benefits of our tax planning initiatives. The company's 2021 GAAP and
adjusted tax rates were also impacted by income tax benefits on intra-entity
transactions totaling $284 million. In 2020, the company's GAAP and adjusted tax
rates were impacted by foreign tax credit planning in Sweden which resulted in
$96 million of foreign tax credits, with no related incremental U.S. income tax
expense; a net income tax benefit of $51 million from a domestication
transaction involving the transfer of non-U.S. subsidiaries to the U.S.; and a
$47 million income tax benefit related to a foreign exchange loss for tax
purposes on certain intercompany financing arrangements. Additionally, the 2020
GAAP tax rate included a $27 million tax benefit from tax audit settlements.

The effective tax rate in both 2021 and 2020 was also affected by relatively
significant earnings in lower tax jurisdictions. Due primarily to the
non-deductibility of intangible asset amortization for tax purposes, the
company's cash payments for income taxes were higher than its income tax expense
for financial reporting purposes and totaled $2.18 billion and $1.32 billion in
2021 and 2020, respectively.

The company expects its GAAP effective tax rate in 2022 will be between 9% and
11% based on currently forecasted rates of profitability in the countries in
which the company conducts business and expected generation of foreign tax
credits. The effective tax rate can vary significantly from period to period as
a result of discrete income tax factors and events. The company expects its
adjusted tax rate will be approximately 13% in 2022.

                                       29

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                         THERMO FISHER SCIENTIFIC INC.
          MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
                           AND RESULTS OF OPERATIONS

Results of Operations (continued)



The company has operations and a taxable presence in approximately 50 countries
outside the U.S. Some of these countries have lower tax rates than the U.S. The
company's ability to obtain a benefit from lower tax rates outside the U.S. is
dependent on its relative levels of income in countries outside the U.S. and on
the statutory tax rates in those countries. Based on the dispersion of the
company's non-U.S. income tax provision among many countries, the company
believes that a change in the statutory tax rate in any individual country is
not likely to materially affect the company's income tax provision or net
income, aside from any resulting one-time adjustment to the company's deferred
tax balances to reflect a new rate.

Liquidity and Capital Resources



The company's proven growth strategy has enabled it to generate free cash flow
as well as access the capital markets. The company deploys its capital primarily
via mergers and acquisitions and secondarily via share buybacks and dividends.

                                    December 31,       December 31,
(In millions)                               2021               2020
Cash and cash equivalents        $       4,477      $      10,325
Total debt                              34,870             21,735


Approximately half of the company's cash balances and cash flows from operations
are from outside the U.S. The company uses its non-U.S. cash for needs outside
of the U.S. including acquisitions, capacity expansion, and repayment of
third-party foreign debt by foreign subsidiaries. In addition, the company also
transfers cash to the U.S. using non-taxable returns of capital as well as
dividends where the related U.S. dividend received deduction or foreign tax
credit equals any tax cost arising from the dividends. As a result of using such
means of transferring cash to the U.S., the company does not expect any material
adverse liquidity effects from its significant non-U.S. cash balances for the
foreseeable future.

The company believes that its existing cash and cash equivalents and its future
cash flow from operations together with available borrowing capacity under its
revolving credit agreement will be sufficient to meet the cash requirements of
its existing businesses for the foreseeable future, including at least the next
24 months.

As of December 31, 2021, the company's short-term debt totaled $2.54 billion. On
January 7, 2022, the company replaced its prior credit facility with a new
revolving credit facility with a bank group that provides up to $5.00 billion of
unsecured multi-currency revolving credit (Note 10). If the company borrows
under this facility, it intends to leave undrawn an amount equivalent to
outstanding commercial paper to provide a source of funds in the event that
commercial paper markets are not available. As of December 31, 2021, no
borrowings were outstanding under the company's revolving credit facility,
although available capacity was reduced by approximately $4 million as a result
of outstanding letters of credit.

(In millions)                                         2021         2020

Net cash provided by operating activities $ 9,312 $ 8,289 Net cash used in investing activities

            (21,932)      (1,510)

Net cash provided by financing activities 6,581 959 Free cash flow (non-GAAP measure)

                  6,809        6,823


During 2021, cash provided by income was offset in part by investments in
working capital. Increases in accounts receivable and inventories used cash of
$204 million and $1.07 billion, respectively, primarily to support growth in
sales. An increase in accounts payable provided cash of $479 million. Changes in
other assets and other liabilities used cash of $724 million primarily due to
the timing of tax and incentive compensation payments. Cash payments for income
taxes were $2.18 billion during 2021.

During 2020, cash provided by income was offset in part by investments in
working capital. Increases in accounts receivable and inventories used cash of
$1.30 billion and $508 million, respectively, primarily to support growth in
sales. Changes in other assets and other liabilities provided cash of $1.45
billion primarily due to the timing of incentive compensation payments and, to a
lesser extent, customer billings. Cash payments for income taxes were $1.32
billion during 2020.

During 2021, acquisitions used cash of $19.40 billion. The company's investing
activities also included the purchase of $2.52 billion of property, plant and
equipment for capacity and capability investments. During 2020, the company's
investing activities were principally for the purchase of property, plant and
equipment.

                                       30

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                         THERMO FISHER SCIENTIFIC INC.
          MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
                           AND RESULTS OF OPERATIONS

Liquidity and Capital Resources (continued)



During 2021, issuance of senior notes provided $18.14 billion of cash. A net
increase in commercial paper obligations provided cash of $2.51 billion.
Repayment of debt used cash of $11.74 billion, including $4.30 billion to repay
the debt assumed in the acquisition of PPD. The company's financing activities
also included the repurchase of $2.00 billion of the company's common stock (4.1
million shares) and the payment of $395 million in cash dividends. On September
23, 2021, the Board of Directors authorized the repurchase of up to $3.00
billion of the company's common stock. Early in the first quarter of 2022, the
company repurchased $2.00 billion of the company's common stock (3.3 million
shares). At February 24, 2022, authorization remained for $1.00 billion of
future repurchases of the company's common stock. As discussed in Note 10, in
the first quarter of 2022 the company redeemed its 3.650% Senior Notes due 2025
for a total cash outlay of $375 million.

During 2020, issuance of senior notes provided cash of $3.46 billion. Repayment
of senior notes used cash of $710 million. The company's financing activities
also included the repurchase of $1.50 billion of the company's common stock (4.5
million shares) and the payment of $337 million in cash dividends.

The company expects that for all of 2022, expenditures for property, plant and equipment, net of disposals, will be between $2.5 and $2.7 billion.



In addition to the obligations on the balance sheet at December 31, 2021, which
include, but are not limited to, debt (Note 10), unrecognized tax benefits (Note
8), operating leases (Note 11) pension obligations (Note 7) and contingent
consideration (Note 14), the company has entered into unconditional purchase
obligations, in the ordinary course of business, that include agreements to
purchase goods, services or fixed assets and to pay royalties (Note 12).

The company is contingently liable with respect to certain legal proceedings and
related matters. An unfavorable outcome that differs materially from current
accrual estimates, if any, for one or more of the matters described under the
heading "Product Liability, Workers Compensation and Other Personal Injury
Matters," in Note 12 could have a material adverse effect on the company's
financial position as well as its results of operations and cash flows.

Non-GAAP Measures



In addition to the financial measures prepared in accordance with generally
accepted accounting principles (GAAP), we use certain non-GAAP financial
measures such as organic revenue growth, which is reported revenue growth,
excluding the impacts of revenues from acquired/divested businesses and the
effects of currency translation. We report organic revenue growth because Thermo
Fisher management believes that in order to understand the company's short-term
and long-term financial trends, investors may wish to consider the impact of
acquisitions and foreign currency translation on revenues. Thermo Fisher
management uses organic revenue growth to forecast and evaluate the operational
performance of the company as well as to compare revenues of current periods to
prior periods.

We report adjusted operating income, adjusted operating income margin, adjusted
other income/(expense), adjusted tax rate, and adjusted EPS. We believe that the
use of these non-GAAP financial measures, in addition to GAAP financial
measures, helps investors to gain a better understanding of our core operating
results and future prospects, consistent with how management measures and
forecasts the company's core operating performance, especially when comparing
such results to previous periods, forecasts, and to the performance of our
competitors. Such measures are also used by management in their financial and
operating decision-making and for compensation purposes. To calculate these
measures we exclude, as applicable:

•Certain acquisition-related costs, including charges for the sale of
inventories revalued at the date of acquisition, significant
transaction/acquisition-related costs, including changes in estimates of
contingent acquisition-related consideration, and other costs associated with
obtaining short-term financing commitments for pending/recent acquisitions. We
exclude these costs because we do not believe they are indicative of our normal
operating costs.

•Costs/income associated with restructuring activities, such as reducing
overhead and consolidating facilities. We exclude these costs because we believe
that the costs related to restructuring activities are not indicative of our
normal operating costs.

•Equity in earnings of unconsolidated entities; impairments of long-lived
assets; and certain other gains and losses that are either isolated or cannot be
expected to occur again with any predictability, including gains/losses on
investments, the sale of businesses, product lines, and real estate, significant
litigation-related matters, curtailments/settlements of pension plans, and the
early retirement of debt. We exclude these items because they are outside of our
normal operations and/or, in certain cases, are difficult to forecast accurately
for future periods.

•The expense associated with the amortization of acquisition-related intangible
assets because a significant portion of the purchase price for acquisitions may
be allocated to intangible assets that have lives of up to 20 years. Exclusion
of

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                         THERMO FISHER SCIENTIFIC INC.
          MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
                           AND RESULTS OF OPERATIONS

Non-GAAP Measures (continued)

the amortization expense allows comparisons of operating results that are consistent over time for both our newly acquired and long-held businesses and with both acquisitive and non-acquisitive peer companies.



•The tax impacts of the above items and the impact of significant tax audits or
events (such as changes in deferred taxes from enacted tax rate changes), the
latter of which we exclude because they are outside of our normal operations and
difficult to forecast accurately for future periods.

We report free cash flow, which is operating cash flow, excluding net capital
expenditures to provide a view of the continuing operations' ability to generate
cash for use in acquisitions and other investing and financing activities. The
company uses this measure as an indication of the strength of the company and
its ability to generate cash for use in acquisitions and other investing and
financing activities. Free cash flow is not a measure of cash available for
discretionary expenditures since we have certain non-discretionary obligations
such as debt service that are not deducted from the measure.

The non-GAAP financial measures of Thermo Fisher Scientific's results of
operations and cash flows included in this Form 10-K are not meant to be
considered superior to or a substitute for Thermo Fisher Scientific's results of
operations prepared in accordance with GAAP. Reconciliations of such non-GAAP
financial measures to the most directly comparable GAAP financial measures are
set forth within the "Overview" and "Results of Operations" sections and below.

(Dollars in millions except per share amounts)                            2021                              2020
Reconciliation of adjusted operating income and
adjusted operating income margin
GAAP operating income                                         $ 10,028             25.6  %       $ 7,794             24.2  %
Cost of revenues charges (a)                                         8              0.0  %             6              0.0  %

Selling, general and administrative charges (credits) (b)

                                                                144              0.4  %           (10)             0.0  %
Restructuring and other costs (c)                                  197              0.5  %            99              0.3  %
Amortization of acquisition-related intangible assets            1,761              4.5  %         1,667              5.2  %
Adjusted operating income (non-GAAP measure)                  $ 12,138             31.0  %       $ 9,556             29.7  %

Reconciliation of adjusted other income/(expense)
GAAP other income/(expense)                                   $   (694)                          $   (76)
Adjustments (d)                                                    732                               121
Adjusted other income/(expense) (non-GAAP measure)            $     38                           $    45

Reconciliation of adjusted tax rate
GAAP tax rate                                                     12.5  %                           11.8  %
Adjustments (e)                                                    2.1  %                            2.5  %
Adjusted tax rate (non-GAAP measure)                              14.6  %                           14.3  %

Reconciliation of adjusted earnings per share GAAP diluted earnings per share (EPS) attributable to Thermo Fisher Scientific Inc.

$  19.46                           $ 15.96
Cost of revenues charges (a)                                      0.02                              0.01

Selling, general and administrative charges (credits) (b)

                                                               0.36                             (0.02)
Restructuring and other costs (c)                                 0.50                              0.25
Amortization of acquisition-related intangible assets             4.43                              4.17
Other income/expense adjustments (d)                              1.84                              0.30
Benefit from income taxes (e)                                    (1.49)                            (1.12)
Equity in losses of unconsolidated entities                       0.01                              0.01
Adjusted EPS (non-GAAP measure)                               $  25.13                           $ 19.56


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                         THERMO FISHER SCIENTIFIC INC.
          MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
                           AND RESULTS OF OPERATIONS

Non-GAAP Measures (continued)



(Dollars in millions except per share amounts)                2021          

2020


Reconciliation of free cash flow
GAAP net cash provided by operating activities           $ 9,312            $ 8,289
Purchases of property, plant and equipment                (2,523)           

(1,474)


Proceeds from sale of property, plant and equipment           20            

8


Free cash flow (non-GAAP measure)                        $ 6,809

$ 6,823

(a) Adjusted results in 2021 exclude charges for the sale of inventories revalued at the date of acquisition. Adjusted results in 2020 exclude $4 million of accelerated depreciation on manufacturing assets to be abandoned due to facility consolidations and $2 million of charges to conform the accounting policies of recently acquired businesses with the company's accounting policies.



(b) Adjusted results in 2021 and 2020 exclude certain third-party expenses
(credits), principally transaction/integration costs (including reimbursement
thereof) related to recent/terminated acquisitions; credits from changes in
estimates of contingent acquisition consideration; and charges associated with
product liability litigation.

(c) Adjusted results in 2021 and 2020 exclude restructuring and other costs
consisting principally of severance, abandoned facility and other expenses of
headcount reductions within several businesses and real estate consolidations,
and charges for impairment of acquired technology. Adjusted results in 2021
exclude $35 million of charges for compensation due to employees of recently
acquired businesses at the date of acquisition.

(d) Adjusted results in 2021 and 2020 exclude net gains on investments and
charges for amortization of bridge loan commitment fees and entering hedging
contracts for recent/terminated acquisitions. Adjusted results in 2021 exclude
$767 million of losses on the early extinguishment of debt. Adjusted results in
2020 exclude $42 million of charges related to terminated interest rate swaps
and $8 million of net charges for the settlement/curtailment of pension plans.

(e) Adjusted provision for income taxes in 2021 and 2020 excludes the incremental tax benefit for the pre-tax reconciling items between GAAP and adjusted net income, incremental tax impacts from audit settlements and incremental tax impacts from adjusting the company's non-U.S. deferred tax balances as a result of tax rate changes.

Critical Accounting Policies and Estimates



The company's discussion and analysis of its financial condition and results of
operations is based upon its financial statements, which have been prepared in
accordance with accounting principles generally accepted in the United States of
America. The preparation of these financial statements requires management to
make estimates and assumptions that affect the reported amounts of assets,
liabilities, revenues and expenses and related disclosure of contingent
liabilities. On an on-going basis, management evaluates its estimates, including
those related to acquisition-related measurements and income taxes. Management
believes the most complex and sensitive judgments, because of their significance
to the consolidated financial statements, result primarily from the need to make
estimates about the effects of matters that are inherently uncertain. Management
bases its estimates on historical experience, current market and economic
conditions and other assumptions that management believes are reasonable. The
results of these estimates form the basis for judgments about the carrying value
of assets and liabilities where the values are not readily apparent from other
sources. Actual results may differ from these estimates under different
assumptions or conditions.

The company believes the following represent its critical accounting policies and estimates used in the preparation of its financial statements:

Acquisition-related Measurements

Business Combinations



The company uses assumptions and estimates in determining the fair value of
assets acquired and liabilities assumed in a business combination. The
determination of the fair value of intangible assets, which represent a
significant portion of the purchase price in many of the company's acquisitions,
requires the use of significant judgment with regard to (i) the fair value and
(ii) whether such intangibles are amortizable or non-amortizable and, if the
former, the period and the method by which the intangible asset will be
amortized. The company estimates the fair value of acquisition-related
intangible assets principally based on projections of cash flows that will arise
from identifiable intangible assets of acquired businesses, which include
estimates of customer attrition and technology obsolesce rates. The projected
cash flows are discounted to determine the present value of the assets at the
dates of acquisition. See Note 2 for additional information about our recent
business combinations.

                                       33

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                         THERMO FISHER SCIENTIFIC INC.
          MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
                           AND RESULTS OF OPERATIONS

Critical Accounting Policies and Estimates (continued)

Goodwill and Indefinite-lived Intangible Assets



The company evaluates goodwill and indefinite-lived intangible assets for
impairment annually and when events occur or circumstances change that would
more likely than not reduce the fair value of the asset below its carrying
amount. Events or circumstances that might require an interim evaluation include
unexpected adverse business conditions, economic factors, unanticipated
technological changes or competitive activities, loss of key personnel and acts
by governments and courts. Goodwill and indefinite-lived intangible assets
totaled $41.92 billion and $1.24 billion, respectively, at December 31, 2021
(see Note 1 for additional information). Estimates of discounted future cash
flows require assumptions related to revenue and operating income growth rates,
discount rates and other factors. For the goodwill impairment tests, the company
considers (i) peer revenues and earnings trading multiples from companies that
have operational and financial characteristics that are similar to the
respective reporting units and (ii) estimated weighted average costs of capital.
Different assumptions from those made in the company's analysis could materially
affect projected cash flows and the company's evaluation of goodwill and
indefinite-lived intangible assets for impairment.

The company performed the quantitative goodwill impairment test for all of its
reporting units and indefinite-lived intangible assets. Indications of fair
value based on projections of cash flows, which increased over the prior year
projections at higher rates than the increases in carrying values, and on peer
revenues, earnings trading multiples and discount rates, which were relatively
consistent with the prior year, were sufficient to conclude that no impairment
of goodwill or indefinite-lived intangible assets existed at the end of the
tenth fiscal month of 2021, the date of the company's annual impairment testing.
There were no interim impairments of goodwill or indefinite-lived intangible
assets in 2021. There can be no assurance, however, that an economic downturn
will not materially adversely affect peer trading multiples and the company's
businesses such that they do not achieve their forecasted profitability and
these assets become impaired. Should the fair value of the company's goodwill or
indefinite-lived intangible assets decline because of reduced operating
performance, market declines, or other indicators of impairment, or as a result
of changes in the discount rate, charges for impairment may be necessary.

Definite-lived Intangible Assets



Definite-lived intangible assets totaled $18.88 billion at December 31, 2021
(see Note 1 for additional information). The company reviews definite-lived
intangible assets for impairment when indication of potential impairment exists,
such as a significant reduction in cash flows associated with the assets. Actual
cash flows arising from a particular intangible asset could vary from projected
cash flows which could imply different carrying values from those established at
the dates of acquisition and which could result in impairment of such asset. The
company recorded impairments of $0.12 billion in 2021 (see Note 16 for
additional information).

Contingent Consideration



The fair value of contingent consideration liabilities, which were initially
exchanged for control of businesses or assumed from acquired businesses, was
$0.32 billion at December 31, 2021. At each reporting period, the fair value of
contingent consideration is determined using either discounted cash flow
analyses, Monte Carlo simulations, or fair values of an underlying
recapitalization investment portfolio. Changes in the fair value of contingent
consideration liabilities can result from changes in estimates of revenue or
operating results or in the timing or likelihood of achieving milestones, as
well as changes in the fair values of the investments underlying the
recapitalization investment portfolio. These changes resulted in
(benefits)/charges of $(0.05) billion during 2021 (see Note 14 for additional
information).

Income Taxes

Unrecognized Tax Benefits

In the ordinary course of business there is inherent uncertainty in quantifying
the company's income tax positions. The company assesses income tax positions
and records tax benefits for all years subject to examination based upon
management's evaluation of the facts, circumstances and information available at
the reporting date. For those tax positions where it is more likely than not
that a tax benefit will be sustained, the company has recorded the largest
amount of tax benefit with a greater than 50 percent likelihood of being
realized upon ultimate settlement with a taxing authority that has full
knowledge of all relevant information. For those income tax positions where it
is not more likely than not that a tax benefit will be sustained, no tax benefit
has been recognized in the financial statements. Should tax return positions
that the company expects are sustainable not be sustained upon audit, the
company could be required to record an incremental tax provision for such taxes.
The company's liability for these unrecognized tax benefits totaled $1.12
billion at December 31, 2021 (see Note 8 for additional information).

                                       34

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                         THERMO FISHER SCIENTIFIC INC.
          MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
                           AND RESULTS OF OPERATIONS

Critical Accounting Policies and Estimates (continued)



The company operates in numerous countries under many legal forms and, as a
result, is subject to the jurisdiction of numerous domestic and non-U.S. tax
authorities, as well as to tax agreements and treaties among these governments.
Determination of taxable income in any jurisdiction requires the company to
interpret the related tax laws and regulations and the use of estimates and
assumptions regarding significant future events, such as the amount, timing and
character of deductions, permissible revenue recognition methods under the tax
law and the sources and character of income and tax credits. Changes in tax
laws, regulations, agreements and treaties, currency exchange restrictions or
the company's level of operations or profitability in each taxing jurisdiction
could have an impact upon the amount of current and deferred tax balances and
hence the company's net income.

Valuation Allowances



The company estimates the degree to which tax assets will result in a benefit,
after consideration of all positive and negative evidence, and provides a
valuation allowance for tax assets that it believes will more likely than not go
unused. In situations in which the company has been able to determine that its
deferred tax assets will be realized, that determination generally relies on
future reversals of taxable temporary differences and expected future taxable
income. If it becomes more likely than not that a tax asset will be used, the
company reverses the related valuation allowance. Any such reversals are
recorded as a reduction of the company's tax provision. The company's tax
valuation allowance totaled $0.97 billion at December 31, 2021 (see Note 8 for
additional information). Should the company's actual future taxable income by
tax jurisdiction vary from estimates, additional allowances or reversals thereof
may be necessary.

Undistributed Earnings

The company has not provided U.S. state income taxes or additional non-U.S.
taxes on certain of its non-U.S. subsidiaries' undistributed earnings, as such
amounts are intended to be reinvested outside the United States indefinitely in
the respective jurisdictions based on specific business plans and tax strategies
(see Note 8 for additional information). These business plans and tax strategies
consider: short-term and long-term forecasts and budgets of the U.S. parent and
non-U.S. subsidiaries; working capital and other needs in locations where
earnings are generated; the company's past practices regarding non-U.S.
subsidiary dividends; sources of financing by the U.S. parent, such as issuing
debt or equity; and uses of cash by the U.S. parent that are more discretionary
in nature, such as business combinations and share repurchase programs. However,
should the company change its business plans and tax strategies in the future
and decide to repatriate a portion of these earnings to one of its U.S.
subsidiaries, including cash maintained by these non-U.S. subsidiaries, the
company would recognize additional tax liabilities. It is not practicable to
estimate the amount of additional U.S. state income tax and non-U.S. tax
liabilities that the company would incur. The company's intent is to only make
distributions from non-U.S. subsidiaries in the future when they can be made at
no net tax costs.

Recent Accounting Pronouncements

A description of recently issued accounting standards is included under the heading "Recent Accounting Pronouncements" in Note 1.

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