Forward-looking statements, within the meaning of Section 21E of the Securities
Exchange Act of 1934 are made throughout this Management's Discussion and
Analysis of Financial Condition and Results of Operations. Any statements
contained herein that are not statements of historical fact may be deemed to be
forward-looking statements, including without limitation statements regarding:
projections of revenues, expenses, earnings, margins, tax rates, tax provisions,
cash flows, pension and benefit obligations and funding requirements, our
liquidity position; cost reductions, restructuring activities, new product and
service developments, competitive strengths or market position, acquisitions or
divestitures; growth, declines and other trends in markets we sell into; new or
modified laws, regulations and accounting pronouncements; outstanding claims,
legal proceedings, tax audits and assessments and other contingent liabilities;
foreign currency exchange rates and fluctuations in those rates; general
economic and capital markets conditions; the timing of any of the foregoing;
assumptions underlying any of the foregoing; the expected impact of the COVID-19
pandemic on the company's business; and any other statements that address events
or developments that Thermo Fisher intends or believes will or may occur in the
future. Without limiting the foregoing, the words "believes," "anticipates,"
"plans," "expects," "seeks," "estimates," and similar expressions are intended
to identify forward-looking statements, although not all forward-looking
statements are accompanied by such words. While the company may elect to update
forward-looking statements in the future, it specifically disclaims any
obligation to do so, even if the company's estimates change, and readers should
not rely on those forward-looking statements as representing the company's views
as of any date subsequent to the date of the filing of this Quarterly Report.
Important factors that could cause actual results to differ materially from
those indicated by such forward-looking statements are set forth under the
caption "Risk Factors" in the company's   Annual Report on Form 10-K   for the
year ended December 31, 2020 (which is on file with the SEC) as updated under
the heading "Risk Factors" in Part II, Item 1A of this report on Form 10-Q.
Important factors that could cause actual results to differ materially from
those indicated by forward-looking statements include risks and uncertainties
relating to: the duration and severity of the COVID-19 pandemic; the need to
develop new products and adapt to significant technological change;
implementation of strategies for improving growth; general economic conditions
and related uncertainties, dependence on customers' capital spending policies
and government funding policies; the effect of economic and political conditions
and exchange rate fluctuations on international operations; use and protection
of intellectual property; the effect of changes in governmental regulations; any
natural disaster, public health crisis or other catastrophic event; and the
effect of laws and regulations governing government contracts, as well as the
possibility that expected benefits related to recent or pending acquisitions,
including our pending acquisition of PPD, Inc., may not materialize as expected.

Overview


The company develops, manufactures and sells a broad range of products that are
sold worldwide. The company expands the product lines and services it offers by
developing and commercializing its own technologies and by making strategic
acquisitions of complementary businesses. The company's operations fall into
four segments (Note 4): Life Sciences Solutions, Analytical Instruments,
Specialty Diagnostics and Laboratory Products and Services.
The company mobilized in early 2020 to support the COVID-19 pandemic response
with products and services that help analyze, diagnose and protect from the
virus. However, the company saw a significant reduction in customer activity in
several businesses by late March 2020 that materially adversely affected
primarily the 2020 results of the Analytical Instruments segment and, to a
lesser extent, some businesses within the company's other three segments. The
extent and duration of the negative impacts continuing into the remainder of
2021 are uncertain and dependent in part on the success of global efforts to
control the pandemic and economic activity ramping up. The company believes the
impacted businesses' long-term prospects remain excellent given the company's
attractive markets served, its industry-leading position and proven growth
strategy. Several of the company's businesses have had a significant increase in
revenues due to sales of product and services addressing diagnosis and treatment
of COVID-19, including test kits and, to a lesser extent, products and services
for therapy and vaccine development and manufacturing. While these positive
impacts are expected to continue through 2021, the duration and extent of future
revenues from such sales are uncertain and dependent primarily on customer
testing as well as therapy and vaccine demand.
Sales in the first quarter of 2021 were $9.91 billion, an increase of $3.68
billion from the first quarter of 2020. Excluding the effects of currency
translation and acquisitions, revenues increased $3.31 billion (53%).
In the first quarter of 2021, total company operating income and operating
income margin were $3.05 billion and 30.8%, respectively, compared with $0.91
billion and 14.5%, respectively, in 2020.
                                       22
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                         THERMO FISHER SCIENTIFIC INC.
          MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
                           AND RESULTS OF OPERATIONS
Overview (continued)
Net income increased to $2.34 billion in the first quarter of 2021 from $0.79
billion in the first quarter of 2020, primarily due to an increase in operating
income, offset in part by an increase in the income tax provision and
$197 million of losses on the early extinguishment of debt.
During the first three months of 2021, the company's cash flow from operations
totaled $1.98 billion compared with $0.36 billion for 2020.
On January 15, 2021, the company acquired, within the Laboratory Products and
Services segment, the Belgium-based European viral vector manufacturing business
of Groupe Novasep SAS for approximately $834 million in net cash consideration.
The European viral vector manufacturing business provides manufacturing services
for vaccines and therapies to biotechnology companies and large biopharma
customers. The acquisition expands the segment's capabilities for cell and gene
vaccines and therapies.
On February 25, 2021, the company acquired, within the Life Sciences Solutions
segment, Mesa Biotech, Inc., a U.S.-based molecular diagnostic company, for
approximately $406 million in net cash consideration and contingent
consideration with an initial fair value of $65 million due upon the completion
of certain milestones. Mesa Biotech has developed and commercialized a PCR based
rapid point-of-care testing platform available for detecting infectious diseases
including COVID-19. The acquisition enables the company to accelerate the
availability of reliable and accurate advanced molecular diagnostics at the
point of care.
On April 15, 2021, the company entered into a definitive agreement under which
it will acquire PPD, Inc. for $47.50 per share for a total cash purchase price
of $17.4 billion plus the assumption of approximately $3.5 billion of net debt.
PPD provides a broad range of clinical research and specialized laboratory
services to enable customers to accelerate innovation and increase drug
development productivity. In 2020, PPD generated revenue of $4.7 billion.. Upon
close of the transaction, PPD will become part of the Laboratory Products and
Services Segment. The transaction, which is expected to be completed by the end
of 2021, is subject to the satisfaction of customary closing conditions,
including the receipt of applicable regulatory approvals. Shareholders holding
in aggregate approximately 60% of the issued and outstanding shares of common
stock of PPD have approved the transaction by written consent. No further action
by other PPD shareholders is required to approve the transaction. The company
intends to finance the purchase price with cash on hand and the net proceeds
from issuance of debt. The company is currently evaluating future debt
financings and the timing of such transactions is subject to market and other
conditions. The company also has available, but it does not currently expect to
utilize, up to $9.5 billion of committed bridge financing.

Critical Accounting Policies and Estimates
Management's Discussion and Analysis and Note 1 to the Consolidated Financial
Statements of the company's   Annual Report on Form 10-K   for 2020, describe
the significant accounting estimates and policies used in preparation of the
consolidated financial statements. There have been no significant changes in the
company's critical accounting policies during the first three months of 2021.

Results of Operations
First Quarter 2021 Compared With First Quarter 2020
                                         Three Months Ended
                                        April 3,           March 28,            Total              Currency              Acquisitions/
(In millions)                               2021                2020           Change           Translation               Divestitures           Operations
Revenues
Life Sciences Solutions         $    4,203             $    1,774          $ 2,429          $        101          $              32          $     2,296
Analytical Instruments               1,387                  1,101              286                    46                          -                  240
Specialty Diagnostics                1,615                    958              657                    32                          -                  625
Laboratory Products and
Services                             3,597                  2,730              867                    92                         76                  699
Eliminations                          (896)                  (333)            (563)                   (8)                         -                 (555)
Consolidated Revenues           $    9,906             $    6,230          $ 3,676          $        263          $             108          $     3,305


                                       23

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                         THERMO FISHER SCIENTIFIC INC.
          MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
                           AND RESULTS OF OPERATIONS
Results of Operations (continued)
Sales in the first quarter of 2021 increased $3.68 billion from the first
quarter of 2020. Aside from the effects of currency translation and
acquisitions, revenues increased $3.31 billion (53%) primarily due to increased
demand. The first quarter of 2021 had three extra selling days in the quarter
compared to the 2020 quarter. The company's fourth quarter of 2021 will have
four fewer selling days than the corresponding 2020 quarter. Sales of products
that address COVID-19 testing and treatment increased $2.68 billion to $2.85
billion in the first quarter of 2021. Sales were particularly strong in
diagnostic and healthcare markets, primarily due to demand for products
supporting customers diagnosing the COVID-19 virus, as well as to customers in
pharma and biotech markets where demand was strong for products and services and
pandemic-related demand for vaccines and therapies also contributed to growth.
Sales to academic and government customers and customers in industrial markets
were strong primarily due to robust customer activity. Sales growth was strong
in each of the company's primary geographic areas during the first quarter of
2021.
In the first quarter of 2021, total company operating income and operating
income margin were $3.05 billion and 30.8%, respectively, compared with $0.91
billion and 14.5%, respectively, in 2020. The increase in operating income was
primarily due to profit on higher sales and, to a lesser extent, sales mix,
offset in part by strategic growth investments in 2021 to support the company's
near and long-term growth. The company's references to strategic growth
investments generally refer to targeted spending for enhancing commercial
capabilities, including expansion of geographic sales reach and e-commerce
platforms, marketing initiatives, expanded service and operational
infrastructure, focused research and development projects and other expenditures
to enhance the customer experience, as well as incentive compensation and
recognition for employees. The company's references throughout this discussion
to productivity improvements generally refer to improved cost efficiencies from
its Practical Process Improvement (PPI) business system including reduced costs
resulting from global sourcing initiatives, a lower cost structure following
restructuring actions, including headcount reductions and consolidation of
facilities, and low cost region manufacturing. Productivity improvements are
calculated net of inflationary cost increases.
In the first quarter of 2021, the company recorded restructuring and other costs
of $38 million. In the first quarter of 2020, the company recorded restructuring
and other costs of $46 million. See Note 12 for restructuring charges expected
in future periods.
Segment Results
Note 4 to the Consolidated Financial Statements of the company's   Annual Report
on Form 10-K   for 2020, describes the company's measurement of segment income.
There have been no significant changes in measurement methods used to determine
segment income.
                                       24
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                         THERMO FISHER SCIENTIFIC INC.
          MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
                           AND RESULTS OF OPERATIONS

Results of Operations (continued)


                                                                      Three Months Ended
                                                               April 3,      March 28,
(Dollars in millions)                                              2021           2020      Change
Revenues
Life Sciences Solutions                                     $  4,203       $  1,774         137  %
Analytical Instruments                                         1,387          1,101          26  %
Specialty Diagnostics                                          1,615            958          69  %
Laboratory Products and Services                               3,597          2,730          32  %
Eliminations                                                    (896)          (333)        169  %
Consolidated Revenues                                       $  9,906       $  6,230          59  %

Segment Income
Life Sciences Solutions                                     $  2,279       $    675         238  %
Analytical Instruments                                           272            171          59  %
Specialty Diagnostics                                            428            236          81  %
Laboratory Products and Services                                 531            295          80  %
Subtotal Reportable Segments                                   3,510          1,377         155  %

Cost of Revenues Charges                                          (8)            (2)
Selling, General and Administrative Charges                      (16)       

(6)


Restructuring and Other Costs                                    (14)       

(38)


Amortization of Acquisition-related Intangible Assets           (423)       

(425)


Consolidated Operating Income                               $  3,049

$ 906 237 %



Reportable Segments Income Margin                               35.4  %        22.1  %
Consolidated Operating Income Margin                            30.8  %     

14.5 %




Income from the company's reportable segments increased 155% to $3.51 billion in
the first quarter of 2021 due primarily to profit on higher sales and, to a
lesser extent, sales mix, offset in part by strategic growth investments.
Life Sciences Solutions
                                       Three Months Ended
                                April 3,      March 28,
(Dollars in millions)               2021           2020       Change
Revenues                     $  4,203       $  1,774          137  %

Operating Income Margin          54.2  %        38.0  %      16.2 pt


Sales in the Life Sciences Solutions segment increased $2.43 billion in the
first quarter of 2021. Sales increased $2.30 billion (129%) due to higher
revenues at existing businesses and $32 million due to acquisitions. The
favorable effects of currency translation resulted in an increase in revenues of
$101 million. The increase in revenues at existing businesses was primarily
driven by demand for testing to diagnose COVID-19 with higher sales of genetic
sciences products and, to a lesser extent, biosciences products. Sales also grew
due to higher demand for bioproduction products.
The increase in operating income margin for the segment resulted primarily from
profit on higher sales and, to a lesser extent, sales mix, offset in part by
strategic growth investments.
                                       25
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                         THERMO FISHER SCIENTIFIC INC.
          MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
                           AND RESULTS OF OPERATIONS
Results of Operations (continued)
Analytical Instruments
                                       Three Months Ended
                                April 3,      March 28,
(Dollars in millions)               2021           2020      Change
Revenues                     $  1,387       $  1,101          26  %

Operating Income Margin          19.6  %        15.5  %      4.1 pt


Sales in the Analytical Instruments segment increased $286 million in the first
quarter of 2021. Sales increased $240 million (22%) due to higher revenues at
existing businesses. The favorable effects of currency translation resulted in
an increase in revenues of $46 million. The increase in revenues at existing
businesses was due to increased demand for products sold by each of the
segment's primary businesses with particular strength in chromatography and mass
spectrometry instruments.
The increase in operating income margin for the segment was primarily due to
profit on higher sales and, to a lesser extent, productivity improvements,
offset in part by sales mix and strategic growth investments.
Specialty Diagnostics
                                        Three Months Ended
                                  April 3,      March 28,
(Dollars in millions)                 2021           2020      Change
Revenues                     $    1,615       $    958          69  %

Operating Income Margin            26.5  %        24.7  %      1.8 pt


Sales in the Specialty Diagnostics segment increased $657 million in the first
quarter of 2021. Sales increased $625 million (65%) due to higher revenues at
existing businesses. The favorable effects of currency translation resulted in
an increase in revenues of $32 million. The increase in revenues at existing
businesses was due to higher demand primarily driven by products addressing
treatment of COVID-19, with particular strength in sales of products sold
through the segment's healthcare market channel business, and to a lesser
extent, microbiology and clinical diagnostics products.
The increase in operating income margin for the segment was primarily due to
profit on higher sales, offset in part by sales mix and, to a lesser extent,
strategic growth investments.
Laboratory Products and Services
                                       Three Months Ended
                                April 3,      March 28,
(Dollars in millions)               2021           2020      Change
Revenues                     $  3,597       $  2,730          32  %

Operating Income Margin          14.8  %        10.8  %      4.0 pt


Sales in the Laboratory Products and Services segment increased $867 million in
the first quarter of 2021. Sales increased $699 million (26%) due to higher
revenues at existing businesses and $76 million due to an acquisition. The
favorable effects of currency translation resulted in an increase in revenues of
$92 million. The increase in revenues at existing businesses was primarily due
to increased demand in each of the segment's principal businesses.
The increase in operating income margin for the segment was primarily due to
profit on higher sales and, to a lesser extent, productivity improvements,
offset in part by strategic growth investments and, to a lesser extent, sales
mix.
Other Income/Expense
The company reported other expense of $183 million in the first quarter of 2021
compared to other income of $12 million in the first quarter of 2020. In 2021,
other expense includes $197 million of losses on the early extinguishment of
debt.
Provision for Income Taxes
The company's effective tax rate was 15.1% for the first quarter of 2021. The
company expects its effective tax rate for all of 2021 will be between 11% and
13% based on currently forecasted rates of profitability in the countries in
which the company
                                       26
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                         THERMO FISHER SCIENTIFIC INC.
          MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
                           AND RESULTS OF OPERATIONS
Results of Operations (continued)
conducts business and expected generation of foreign tax credits. Due primarily
to the non-deductibility of intangible asset amortization for tax purposes, the
company's cash payments for income taxes are higher than its income tax expense
for financial reporting purposes and are expected to total approximately
$1.5 billion in 2021. In the first quarter of 2020, the company's effective tax
rate was 4.8%.
The company has operations and a taxable presence in approximately 50 countries
outside the U.S. Some of these countries have lower tax rates than the U.S. The
company's ability to obtain a benefit from lower tax rates outside the U.S. is
dependent on its relative levels of income in countries outside the U.S. and on
the statutory tax rates in those countries. Based on the dispersion of the
company's non-U.S. income tax provision among many countries, the company
believes that a change in the statutory tax rate in any individual country is
not likely to materially affect the company's income tax provision or net
income, aside from any resulting one-time adjustment to the company's deferred
tax balances to reflect a new rate.

Recent Accounting Pronouncements A description of recently issued accounting standards is included under the heading "Recent Accounting Pronouncements" in Note 1.



Liquidity and Capital Resources
Consolidated working capital (current assets less current liabilities) was
$10.69 billion at April 3, 2021, compared with $11.65 billion at December 31,
2020. Included in working capital were cash and cash equivalents of $5.58
billion at April 3, 2021 and $10.33 billion at December 31, 2020.
First Three Months of 2021
Cash provided by operating activities during the first three months of 2021 was
$1.98 billion. Cash provided by income was offset in part by investments in
working capital. A decrease in accounts receivable provided $149 million of
cash. An increase in inventories used cash of $352 million, primarily to support
growth in sales. Changes in other assets and other liabilities used cash of
$1.20 billion primarily due to the timing of payments for compensation. Cash
payments for income taxes increased to $542 million during the first three
months of 2021, compared with $100 million in the first three months of 2020.
During the first three months of 2021, the company's investing activities used
$2.00 billion of cash. Acquisitions used cash of $1.34 billion. The company's
investing activities also included the purchase of $628 million of property,
plant and equipment for capacity and capability investments.
The company's financing activities used $4.85 billion of cash during the first
three months of 2021. Repayment of senior notes used cash of $2.80 billion. The
company's financing activities also included the repurchase of $2.00 billion of
the company's common stock and the payment of $87 million in cash dividends. On
November 5, 2020, the Board of Directors replaced the existing authorization to
repurchase the company's common stock with a new authorization to repurchase up
to $2.50 billion of the company's common stock. At May 7, 2021, authorization
remained for $500 million of future repurchases of the company's common stock.
The company's commitments for purchases of property, plant and equipment,
contractual obligations and other commercial commitments did not change
materially between December 31, 2020 and April 3, 2021 except for the agreement
to acquire PPD, discussed in Note 2. The company expects that for all of 2021,
expenditures for property, plant and equipment, net of disposals, will be
between $2.5 and $2.7 billion.
As of April 3, 2021, the company's short-term debt totaled $4 million. The
company has a revolving credit facility with a bank group that provides up to
$3.00 billion of unsecured multi-currency revolving credit (Note 7). If the
company borrows under this facility, it intends to leave undrawn an amount
equivalent to outstanding commercial paper to provide a source of funds in the
event that commercial paper markets are not available. As of April 3, 2021, no
borrowings were outstanding under the company's revolving credit facility,
although available capacity was reduced by approximately $31 million as a result
of outstanding letters of credit.
Approximately half of the company's cash balances and cash flows from operations
are from outside the U.S. The company uses its non-U.S. cash for needs outside
of the U.S. including acquisitions and repayment of acquisition-related
intercompany debt to the U.S. In addition, the company also transfers cash to
the U.S. using non-taxable returns of capital as well as dividends where the
related U.S. dividend received deduction or foreign tax credit equals any tax
cost arising from the
                                       27
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                         THERMO FISHER SCIENTIFIC INC.
          MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
                           AND RESULTS OF OPERATIONS
Liquidity and Capital Resources (continued)
dividends. As a result of using such means of transferring cash to the U.S., the
company does not expect any material adverse liquidity effects from its
significant non-U.S. cash balances for the foreseeable future.
The company believes that its existing cash and cash equivalents and its future
cash flow from operations together with available borrowing capacity under its
revolving credit agreement and bridge loan agreement will be sufficient to meet
the cash requirements of its existing businesses for the foreseeable future,
including at least the next 24 months and to fund the pending PPD acquisition.
First Three Months of 2020
Cash provided by operating activities was $356 million during the first three
months of 2020. Cash provided by income was offset in part by investments in
working capital. Increases in accounts receivable and inventories used cash of
$218 million and $141 million, respectively, primarily to support growth in
sales. Changes in other assets and other liabilities used cash of $443 million
primarily due to the timing of customer billings. Cash payments for income taxes
totaled $100 million.
During the first three months of 2020, the company's investing activities used
$260 million of cash, principally for the purchase of property, plant and
equipment.
The company's financing activities provided $619 million of cash during the
first three months of 2020. Issuance of senior notes provided cash of $2.19
billion. The company's financing activities also included the repurchase of
$1.50 billion of the company's common stock and the payment of $76 million in
cash dividends.

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