Thermo Fisher Scientific Inc. announced Thermo Scientific EliA RNA Pol III and EliA Rib-P tests have been cleared by the U.S. Food & Drug Administration (FDA) for aiding in the diagnosis of Systemic Sclerosis (SSc; scleroderma) and Systemic Lupus Erythematosus (SLE). With these new tests, the EliA portfolio provides a more robust clinical offering through a comprehensive menu of automated connective tissue disease tests. RNA Polymerase III is a criteria marker for SSc with both diagnostic and prognostic value.[1, 2] Additionally, in patients who are positive for RNA Polymerase III, up to 70% may have no other SSc associated antibodies present.[2] The EliA RNA Pol III test completes a criteria based EliA SSc panel and is the first fully automated RNA Polymerase test available in the U.S. A subset of SLE patients present with monospecific Ribosomal P antibodies.[3] Detection of these autoantibodies via indirect immunofluorescence has been shown to be an unreliable method, which if used solely, could result in delayed diagnosis and treatment.[4] The EliA Rib-P test is designed with optimal sensitivity and specificity and can be used to support the diagnosis of SLE, particularly in ANA negative patients.