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    ALTME   NL0015000YE1

TME PHARMA N.V.

(ALTME)
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Real-time Euronext Paris  -  11:21:10 2023-01-27 am EST
1.150 EUR   -3.97%
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TME Pharma Announces Positive Updated Interim Results from NOX-A12 GLORIA Phase 1/2 in Brain Cancer Presented at the Society for Neuro-oncology 2022 Annual Meeting

11/18/2022 | 07:30pm EST

TME Pharma N.V. announced the presentation of updated interim results from the GLORIA Phase 1/2 clinical trial expansion arm with NOX-A12 combined with radiotherapy and bevacizumab (biosimilar Avastin®) in chemotherapy-refractory (MGMT unmethylated) brain cancer (glioblastoma) in a poster presentation at the Society for Neuro-Oncology (SNO) Annual Meeting, held in Tampa, Florida, US from November 16 – 20, 2022. The company additionally disclosed newer data from the expansion arm that became available after the presentation submission cut-off date, as well as results from the completed dose-escalation part of the same clinical trial. The poster as well as the most recent data highlight the following key points: 100% of target lesions treated with the triple combination of NOX-A12, radiotherapy and bevacizumab were reduced by more than 50%.

5 of 6 patients (83%) achieved durable partial responses (PR) by mRANO criteria1, which takes into account radiographic response as well as other factors such as clinical condition of the patient. One patient experienced progressive disease (PD) due to distant failure while target lesion control was maintained. 2 of 6 patients achieved almost complete tumor size reduction (>99%) where contrast enhancing lesions were detectable but too small to be measured.

The data for the second patient achieving >99% decrease in tumor size was obtained shortly after the data cut-off for the poster and will be presented in the webinar on November 22, 2022. The mean best sum of perpendicular diameters (SPD) of the tumor response was -74.9% (-53.8% to -99.9%) for target lesion sums. The triple combination was well tolerated and safe. No dose-limiting toxicities were observed.


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All news about TME PHARMA N.V.
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Financials
Sales 2021 0,03 M 0,04 M 0,04 M
Net income 2021 -14,5 M -15,7 M -15,7 M
Net cash 2021 7,02 M 7,62 M 7,62 M
P/E ratio 2021 -1,07x
Yield 2021 -
Capitalization 1,56 M 1,70 M 1,70 M
EV / Sales 2020 405x
EV / Sales 2021 316x
Nbr of Employees 13
Free-Float 12,3%
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Managers and Directors
Aram Andrew Mangasarian Chief Business Officer
Maurizio PetitBon Chairman-Supervisory Board
Cornelis Alexander Izeboud Member-Supervisory Board
Martine J. van Vugt Member-Supervisory Board
Susan Coles Member-Supervisory Board
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