The following discussion and analysis of our financial condition and results of
operations should be read in conjunction with our consolidated financial
statements and related notes appearing elsewhere in this Annual Report on
Form 10-K. In addition to historical financial information, the following
discussion contains forward-looking statements that are based upon current
plans, expectations and beliefs that involve risks and uncertainties. Our actual
results may differ materially from those anticipated in these forward-looking
statements as a result of various factors, including those set forth under
Part I, Item 1A, "Risk Factors" in this Annual Report on Form 10-K. Our fiscal
year ends on December 31.

                                    Overview

We are the leader in the cloud communications platform category. We enable
developers to build, scale and operate real­time customer engagement within
their software applications. We offer a customer engagement platform with
software designed to address specific use cases like account security and
contact centers, and a set of Application Programming Interfaces ("APIs") that
handles the higher level communication logic needed for nearly every type of
customer engagement. The power, flexibility and reliability offered by our
software building blocks empower companies of virtually every shape and size to
build world-class engagement into their customer experience. For additional
detail on the description of our business and products please refer to Part I,
Item 1, "Business", included elsewhere on this Annual Report on Form 10-K.

We have achieved significant growth in recent periods. In the years ended
December 31, 2021, 2020 and 2019, our revenue was $2.8 billion, $1.8 billion and
$1.1 billion, respectively, and our net loss was $949.9 million, $491.0 million
and $307.1 million, respectively. In the years ended December 31, 2021, 2020 and
2019, our 10 largest Active Customer Accounts generated an aggregate of 11%, 14%
and 13% of our total revenue, respectively.

Acquisition of Zipwhip, Inc. in 2021



In July 2021, we acquired Zipwhip, Inc. ("Zipwhip"), a leading provider of
toll-free messaging in the United States, for a purchase price of
$838.8 million. The purchase price was paid in the form of shares of our Class A
common stock and cash and included fair value of pre-combination services of
Zipwhip employees that was embedded in the unvested equity awards which we
assumed on the acquisition closing date. Part of the cash was paid to settle the
vested stock options of Zipwhip employees that were outstanding on the
acquisition closing date. We assumed all unvested and outstanding stock options
and restricted stock units of Zipwhip continuing employees as converted into our
own respective equity awards at the conversion ratio provided in the Agreement
and Plan of Merger and Reorganization. Vesting of Class A shares of our common
stock and assumed equity awards that were subject to service conditions is
recorded into our stock-based compensation expense as the services are provided.
This acquisition is described in detail in Note 7 to our consolidated financial
statements included elsewhere in this Annual Report on Form 10-K.
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Because the acquisition of Zipwhip occurred during the year ended December 31,
2021, the information presented in this section with respect to the year ended
December 31, 2021 includes the contribution of Zipwhip starting from July 14,
2021, the date of acquisition. The information with respect to the periods prior
to the date of acquisition relates to Twilio on a standalone basis, not
including Zipwhip. As a result, comparisons to prior periods may not be
indicative of future results or future rates of growth.

Acquisition of Segment.io, Inc. in 2020



In November 2020, we acquired Segment.io, Inc. ("Segment"), the market-leading
customer data platform, for a purchase price of $3.0 billion. The purchase price
was paid in the form of shares of our Class A common stock and cash and included
fair value of pre-combination services of Segment employees that was embedded in
the unvested equity awards which we assumed on the acquisition closing date.
Part of the cash was paid to settle the vested equity awards of Segment
employees that were outstanding on the acquisition closing date. We assumed all
unvested and outstanding equity awards of Segment continuing employees as
converted into our own equity awards at the conversion ratio provided in the
Agreement and Plan of Reorganization. Vesting of Class A shares of our common
stock and assumed equity awards that were subject to service conditions is
recorded into our stock-based compensation expense over the period the services
are provided. This acquisition is described in detail in Note 7 to our
consolidated financial statements included elsewhere in this Annual Report on
Form 10-K.

Because the acquisition of Twilio Segment occurred during the year ended
December 31, 2020, the information presented in this section with respect to the
year ended December 31, 2020 includes the contribution of Twilio Segment
starting from November 2, 2020, the date of acquisition. The information with
respect to periods prior to the date of acquisition relates to Twilio on a
standalone basis, not including Segment. The information with respect to year
2021 includes Segment results for the full year. As a result, comparisons to
prior periods or the current full year period may not be indicative of future
results or future rates of growth.

Investment in Syniverse Corporation



In February 2021, we entered into a Framework Agreement, as amended, with
Syniverse Corporation ("Syniverse") and Carlyle Partners V Holdings, L.P.,
("Framework Agreement"), pursuant to which Syniverse would issue to us shares of
Syniverse common stock in consideration for an investment by us of up to $750.0
million, subject to certain terms and conditions. The initial agreements and
conditions to closing of this transaction are described in detail in Note 13(a)
to our consolidated financial statements included elsewhere in this Annual
Report on Form 10-K.

On February 9, 2022, Syniverse mutually terminated a proposed Agreement and Plan
of Merger with M-3 Brigade Acquisition II Corp. ("MBAC") because the rate of
MBAC shareholder redemptions for the proposed transaction would have exceeded
the minimum cash condition for closing, which occurred as a result of recent
changes in market conditions ("MBAC Transaction Termination"). Because of the
MBAC Transaction Termination, Twilio will not purchase any shares of common
stock of, or make any investment in, MBAC.

The Framework Agreement, dated as of February 26, 2021, by and between Twilio,
Syniverse and Carlyle Partners V Holdings, L.P., remains in full force and
effect. The amendment, dated as of August 16, 2021, to the Framework Agreement
terminated on February 9, 2022, as a result of the MBAC Transaction Termination.
Pursuant to the terms and subject to the closing conditions set forth in the
Framework Agreement, the parties thereto are pursuing the alternative
transaction, whereby Twilio will make a minority investment of $500.0 million to
$750.0 million in Syniverse and the parties (or their applicable subsidiaries)
will enter into a wholesale agreement.

Public Equity Offerings



In February 2021, August 2020 and June 2019, we completed public equity
offerings in which we sold 4,312,500 shares, 5,819,838 shares and 8,064,515
shares, respectively, of our Class A common stock at public offering prices of
$409.60 per share, $247.00 per share and $124.00 per share, respectively. We
received aggregate proceeds of $1.8 billion, $1.4 billion and $979.0 million,
respectively, after deducting underwriting discounts and offering expenses paid
by us.

Issuance of 2029 and 2031 Senior Notes



In March 2021, we issued and sold $1.0 billion aggregate principal amount of
senior notes, consisting of $500.0 million principal amount of 3.625% notes due
2029 (the "2029 Notes") and $500.0 million principal amount of 3.875% notes due
2031 (the "2031 Notes," and together with the 2029 Notes, the "Notes"). The net
proceeds from the offering of these Notes were
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approximately $984.7 million, after deducting underwriting discounts and
issuance costs paid by us. These Notes are described in detail in Note 10 to our
consolidated financial statements included elsewhere in this Annual Report on
Form 10-K.

Redemption of Convertible Senior Notes and Capped Call Transactions



During 2021 we issued a notice of redemption for our convertible senior notes
due 2023 (the "Convertible Notes") and on June 2, 2021, we redeemed all of the
remaining outstanding principal amount of the notes. During 2021 and through the
date of the redemption, we converted $343.7 million aggregate principal amount
of the Convertible Notes by issuing 4,846,965 shares of our Class A common
stock. The extinguishment of these notes resulted in a $29.0 million loss that
is included in other (expenses) income, net, in our consolidated statement of
operations included elsewhere in this Annual Report on Form 10-K.

Concurrently with the principal redemption, we settled the related capped call
arrangements that were entered into contemporaneously with the Convertible Notes
offering in May 2018. The capped call arrangements were settled for gross cash
consideration of $229.8 million that we received and recorded as additional
paid-in-capital, net of $1.4 million of transaction costs and a $3.2 million
realized gain. These transactions are described in detail in Note 10 to our
consolidated financial statements included elsewhere in this Annual Report on
Form 10-K.

                                COVID-19 UPDATE

The rapid spread of the COVID-19 globally has disrupted, and may continue to
disrupt, our day-to-day operations and the operations of our customers, partners
and service providers for an indefinite period of time, including as a result of
changing public health recommendations, travel restrictions and limitations, the
duration, spread and severity and potential recurrence of the virus and its
variants, as well as the efficacy of vaccines and vaccine distribution and the
timing and trajectory of the economic recovery, all of which could negatively
impact our business and results of operations and financial condition. Since
mid-March 2020, we have taken precautionary measures to protect our employees
and contingent workers and to help minimize the spread of the virus by
temporarily closing our worldwide offices and minimizing business travel. We
have continued to monitor the progress of vaccination efforts around the world.
In the second half of 2021, as COVID-19 related restrictions have eased in some
geographies, we commenced a phased reopening for certain offices.

The broader implications of COVID-19 on our results of operations and overall
financial performance remain uncertain. The COVID-19 pandemic and its adverse
effects on economic and market conditions, including labor shortages, supply
chain disruptions and inflation, have been prevalent in the locations where we,
our customers, our suppliers or our third-party business partners conduct
business. These adverse conditions may continue for an extended period and there
may be additional impacts to the economy and our business as a result of
COVID-19. This could result in decreased business spending by our customers and
prospective customers and business partners and third-party business partners,
reduced demand for our solutions, lower renewal rates by our customers, longer
or delayed sales cycles, including customers and prospective customers delaying
contract signing or contract renewals, or reducing budgets or minimum
commitments related to the product and services that we offer, all of which
could have an adverse impact on our business operations and financial condition.
See the risk factor titled "The global COVID-19 pandemic may adversely impact
our business, results of operations and financial condition" in Part I, Item 1A,
"Risk Factors" of this Annual Report on Form 10-K for further discussion of the
possible impact of the COVID-19 pandemic on our business, financial condition
and results of operations.
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                              Key Business Metrics

                                                                          Year Ended December 31,
                                                               2021                 2020                 2019

Number of Active Customer Accounts (as of end date of period) (1)

                                                256,000              221,000              179,000
Total Revenue (in thousands) (1)                          $ 2,841,839          $ 1,761,776          $ 1,134,468
Total Revenue Growth Rate (1)                                      61  %                55  %                75  %
Dollar-Based Net Expansion Rate (2)                               131  %               137  %               135  %

____________________


(1) Includes the contributions from our Zipwhip business, acquired July 14, 2021; Twilio Segment business,
acquired November 2, 2020; Twilio SendGrid business, acquired February 1, 2019; and other smaller acquisitions
from the dates of their respective acquisitions except for the Number of Active Customer Accounts, which excludes
customer accounts from our Zipwhip business.

(2) As previously announced in our Annual Report on Form 10-K filed with the SEC on March 2, 2020, commencing with
the three-month period ended March 31, 2020, we calculate our Dollar-Based Net Expansion Rate by comparing total
revenue from a cohort of Active Customer Accounts in a period to the same period in the prior year (the "New DBNE
Definition"). To facilitate comparison between the periods presented, Dollar-Based Net Expansion Rate as presented
in the table above has been calculated as if the New DBNE Definition had been in effect during that period. As a
result of the New DBNE Definition, unless specifically identified as being calculated using total revenue, any
Dollar-Based Net Expansion Rates disclosed by us in our SEC filings, press releases and presentations prior to the
date of our press release for the three months ended March 31, 2020, will not be directly comparable to our
Dollar-Based Net Expansion Rates going forward. Unless an acquisition closes on the first day of a quarter,
revenue from an acquisition will not impact this calculation until the quarter following the one year anniversary
of the acquisition.


Number of Active Customer Accounts. We believe that the number of Active
Customer Accounts is an important indicator of the growth of our business, the
market acceptance of our platform and future revenue trends. We define an
"Active Customer Account" at the end of any period as an individual account, as
identified by a unique account identifier, for which we have recognized at least
$5 of revenue in the last month of the period. We believe that use of our
platform by customers at or above the $5 per month threshold is a stronger
indicator of potential future engagement than trial usage of our platform or
usage at levels below $5 per month. In the years ended December 31, 2021, 2020
and 2019, revenue from Active Customer Accounts represented over 99% of total
revenue in each period. A single organization may constitute multiple unique
Active Customer Accounts if it has multiple account identifiers, each of which
is treated as a separate Active Customer Account.

Dollar­Based Net Expansion Rate. Our ability to drive growth and generate
incremental revenue depends, in part, on our ability to maintain and grow our
relationships with existing Active Customer Accounts and to increase their use
of the platform. An important way in which we have historically tracked
performance in this area is by measuring the Dollar-Based Net Expansion Rate for
Active Customer Accounts. Our Dollar-Based Net Expansion Rate increases when
such Active Customer Accounts increase their usage of a product, extend their
usage of a product to new applications or adopt a new product. Our Dollar-Based
Net Expansion Rate decreases when such Active Customer Accounts cease or reduce
their usage of a product or when we lower usage prices on a product. As our
customers grow their businesses and extend the use of our platform, they
sometimes create multiple customer accounts with us for operational or other
reasons. As such, when we identify a significant customer organization (defined
as a single customer organization generating more than 1% of revenue in a
quarterly reporting period) that has created a new Active Customer Account, this
new Active Customer Account is tied to, and revenue from this new Active
Customer Account is included with, the original Active Customer Account for the
purposes of calculating this metric. We believe that measuring Dollar-Based Net
Expansion Rate provides a more meaningful indication of the performance of our
efforts to increase revenue from existing customers.

For historical periods through December 31, 2019, our Dollar-Based Net Expansion
Rate compared the revenue from Active Customer Accounts, other than large Active
Customer Accounts that have never entered into 12-month minimum revenue
commitment contracts with us, in a quarter to the same quarter in the prior
year. For reporting periods starting with the three months ended March 31, 2020,
our Dollar-Based Net Expansion Rate compares the revenue from all Active
Customer Accounts in a quarter to the same quarter in the prior year. To
calculate the Dollar-Based Net Expansion Rate, we first identify the cohort of
Active Customer Accounts that were Active Customer Accounts in the same quarter
of the prior year. The Dollar-Based Net Expansion Rate is the quotient obtained
by dividing the revenue generated from that cohort in a quarter, by the revenue
generated from that same cohort in the corresponding quarter in the prior year.
When we calculate Dollar-Based Net Expansion Rate for periods longer than one
quarter, we use the average of the applicable quarterly Dollar-Based Net
Expansion Rates for each of the quarters in such period. Revenue from
acquisitions does not impact the Dollar-Based Net Expansion Rate calculation
until the quarter following the one-year anniversary of the applicable
acquisition, unless the acquisition closing date is the first day of a quarter.
As a result of the change in calculation of Dollar-Based Net Expansion Rate,
unless specifically identified as being calculated based on total revenue, any
Dollar-Based Net Expansion Rates disclosed by us in our SEC filings, press
releases and presentations prior to the date of our press release for the three
months ended March 31, 2020, will not be directly comparable to our Dollar-Based
Net Expansion Rates going forward.
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                             Net Loss Carryforwards

At December 31, 2021, we had federal, state and foreign net operating loss
carryforwards of approximately $4.2 billion, $2.7 billion and $268.7 million,
respectively, and federal and state tax credits of approximately $132.9 million
and $84.9 million, respectively. If not utilized, the federal and state loss
carryforwards will expire at various dates beginning in 2029 and 2025,
respectively, and the federal tax credits will expire at various dates beginning
in 2029. The state tax credits can be carried forward indefinitely. At present,
we believe that it is more likely than not that the federal and state net
operating loss and credit carryforwards will not be realized. Accordingly, a
full valuation allowance has been established for these tax attributes, as well
as the rest of the federal and state deferred tax assets.

                   Key Components of Statements of Operations

Revenue. We derive our revenue primarily from usage­based fees earned from
customers using the software products within our Channel APIs. These usage­based
software products include offerings, such as Programmable Messaging,
Programmable Voice and Programmable Video, among others. Some examples of the
usage­based fees that we charge include the number of text messages sent or
received using our Programmable Messaging products, minutes of call duration
activity for our Programmable Voice products and the number of authentications
for our Verify product. In the years ended December 31, 2021, 2020 and 2019, we
generated 72%, 76% and 75% of our revenue, respectively, from usage­based fees.
We also earn monthly flat fees from certain fee­based products, such as our
Email API, Marketing Campaigns, Twilio Flex, our cloud contact center platform,
and Twilio Segment, our customer data platform.

When customers first begin using our platform, they typically pay upfront via
credit card in monthly prepaid amounts and draw down their balances as they
purchase or use our products. Our larger customers often enter into contracts
for at least 12 months, that contain minimum revenue commitments, which may
contain more favorable pricing. Customers on such contracts typically are
invoiced monthly in arrears for products used.

Amounts that have been charged via credit card or invoiced are recorded in
revenue, deferred revenue or customer deposits, depending on whether the revenue
recognition criteria have been met. Our deferred revenue and customer deposits
liability balance is not a meaningful indicator of our future revenue at any
point in time because the number of contracts with our invoiced customers that
contain terms requiring any form of prepayment is not significant.

We define U.S. revenue as revenue from customers with IP addresses or mailing
addresses at the time of registration in the United States, and we define
international revenue as revenue from customers with IP addresses or mailing
addresses at the time of registration outside of the United States.

Cost of Revenue and Gross Margin. Cost of revenue consists primarily of fees
paid to network service providers. Cost of revenue also includes cloud
infrastructure fees, direct costs of personnel, such as salaries and stock­based
compensation for our customer support employees, and non­personnel costs, such
as depreciation and amortization expense related to data centers and hosting
equipment, amortization of capitalized internal use software development costs
and acquired intangibles. Our arrangements with network service providers
require us to pay fees based on the volume of phone calls initiated or text
messages sent, as well as the number of telephone numbers acquired by us to
service our customers. Our arrangements with our cloud infrastructure provider
require us to pay fees based on our server capacity consumption.

Our gross margin has been and will continue to be affected by a number of
factors, including the timing and extent of our investments in our operations;
our product mix; our ability to manage our network service provider and cloud
infrastructure­related fees, including A2P SMS fees; the mix of U.S. revenue
compared to international revenue; changes in foreign exchange rates; the timing
of amortization of capitalized software development costs and acquired
intangibles; and the extent to which we periodically choose to pass on our cost
savings from platform optimization efforts to our customers in the form of lower
usage prices.

Operating Expenses. The most significant components of operating expenses are
personnel costs, which consist of salaries, benefits, sales commissions and
bonuses and stock­based compensation. We also incur other non­personnel costs
related to our general overhead expenses. We expect that our operating costs
will increase in absolute dollars as we add additional employees and invest in
our infrastructure to grow our business.
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Research and Development. Research and development expenses consist primarily of
personnel costs, outsourced engineering services, cloud infrastructure fees for
staging and development, amortization of capitalized internal use software
development costs, depreciation and an allocation of our general overhead
expenses. We capitalize the portion of our software development costs that meets
the criteria for capitalization.

We continue to focus our research and development efforts on adding new features
and products, including new use cases, improving our platform and increasing the
functionality of our existing products.

Sales and Marketing. Sales and marketing expenses consist primarily of personnel
costs, including commissions for our sales employees. Sales and marketing
expenses also include expenditures related to advertising, marketing, our brand
awareness activities and developer evangelism, costs related to our SIGNAL
customer and developer conferences, credit card processing fees, professional
services fees, depreciation, amortization of acquired intangibles and an
allocation of our general overhead expenses.

We focus our sales and marketing efforts on generating awareness of our company,
platform and products, creating sales leads and establishing and promoting our
brand, both domestically and internationally. We plan to continue investing in
sales and marketing by increasing our sales and marketing headcount,
supplementing our self­service model with an enterprise sales approach,
expanding our sales channels, driving our go­to­market strategies, building our
brand awareness and sponsoring additional marketing events.

General and Administrative. General and administrative expenses consist
primarily of personnel costs for our accounting, finance, legal, human resources
and administrative support personnel. General and administrative expenses also
include costs related to business acquisitions, legal and other professional
services fees, certain taxes, depreciation and amortization, charitable
contributions and an allocation of our general overhead expenses. We expect that
we will incur costs associated with supporting the growth of our business and to
meet the increased compliance requirements associated with our international
expansion. We may also incur higher than usual losses related to deterioration
of quality of certain financial assets caused by the macroeconomic conditions
and uncertainly in the COVID-19 environment.

Our general and administrative expenses include a certain amount of prior non-income-based taxes in certain domestic and international jurisdictions that we are subject to based on the manner we sell and deliver our products. Additional details are provided in Note 13(d) to our consolidated financial statements included elsewhere in this Annual Report on Form 10-K.



Provision for Income Taxes. Our income tax provision or benefit consists
primarily of income taxes, withholding taxes in foreign jurisdictions in which
the Company conducts business and the tax benefit related to the release of
valuation allowance from acquisitions. The primary difference between our
effective tax rate and the federal statutory rate relates to the full valuation
allowance the Company established on the federal, state and certain foreign net
operating losses and credits.

Non-GAAP Financial Measures:



We use the following non­GAAP financial information, collectively, to evaluate
our ongoing operations and for internal planning and forecasting purposes. We
believe that non­GAAP financial information, when taken collectively, may be
helpful to investors because it provides consistency and comparability with past
financial performance, facilitates period­to­period comparisons of results of
operations and assists in comparisons with other companies, many of which use
similar non­GAAP financial information to supplement their GAAP results.
Non­GAAP financial information is presented for supplemental informational
purposes only, should not be considered a substitute for financial information
presented in accordance with generally accepted accounting principles, and may
be different from similarly­titled non­GAAP measures used by other companies.
Whenever we use a non­GAAP financial measure, a reconciliation is provided to
the most closely applicable financial measure stated in accordance with
generally accepted accounting principles. Investors are encouraged to review the
related GAAP financial measures and the reconciliation of these non­GAAP
financial measures to their most directly comparable GAAP financial measures.
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Non­GAAP Gross Profit and Non­GAAP Gross Margin. For the periods presented, we
define non­GAAP gross profit and non­GAAP gross margin as GAAP gross profit and
GAAP gross margin, respectively, adjusted to exclude, as applicable, certain
expenses as presented in the table below:

                                                                     Year Ended December 31,
                                                        2021                  2020                  2019
Reconciliation:                                                          (In thousands)
Gross profit                                       $  1,390,713          $    915,661          $    608,917
Gross margin                                                 49  %                 52  %                 54  %
Non-GAAP adjustments:
Stock-based compensation                                 14,074                 8,857                 7,123
Amortization of acquired intangibles                    114,896                59,501                45,267
Payroll taxes related to stock-based
compensation                                                  -                     -                   104
  Non-GAAP gross profit                            $  1,519,683          $    984,019          $    661,411
  Non-GAAP gross margin                                      53  %                 56  %                 58  %


Non­GAAP Operating Expenses. For the periods presented, we define non­GAAP
operating expenses (including categories of operating expenses) as GAAP
operating expenses (and categories of operating expenses) adjusted to exclude,
as applicable, certain expenses as presented in the table below:

                                                                       Year Ended December 31,
                                                          2021                  2020                  2019
Reconciliation:                                                            (In thousands)
Operating expenses                                   $  2,306,297          $  1,408,562          $    978,702
Non-GAAP adjustments:
Stock-based compensation                                 (618,211)             (353,054)             (257,195)
Amortization of acquired intangibles                      (83,888)              (38,993)              (27,540)

Acquisition-related expenses                               (7,449)              (21,765)              (15,713)

Charitable contributions                                  (31,169)              (18,993)                    -

Payroll taxes related to stock-based
compensation                                              (48,417)              (27,389)              (15,084)
Non-GAAP operating expenses                          $  1,517,163          $    948,368          $    663,170


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Non­GAAP Income (Loss) from Operations and Non­GAAP Operating Margin. For the
periods presented, we define non­GAAP income (loss) from operations and non­GAAP
operating margin as GAAP loss from operations and GAAP operating margin,
respectively, adjusted to exclude, as applicable, certain expenses as presented
in the table below:

                                                                       Year Ended December 31,
                                                          2021                  2020                  2019
Reconciliation:                                                            (In thousands)
Loss from operations                                 $   (915,584)         $   (492,901)         $   (369,785)
Operating margin                                              (32) %                (28) %                (33) %
Non-GAAP adjustments:
Stock-based compensation                                  632,285               361,911               264,318
Amortization of acquired intangibles                      198,784                98,494                72,807

Acquisition-related expenses                                7,449                21,765                15,713

Charitable contributions                                   31,169                18,993                     -

Payroll taxes related to stock-based
compensation                                               48,417                27,389                15,188
Non-GAAP income (loss) from operations               $      2,520          $     35,651          $     (1,759)
Non-GAAP operating margin                                       -  %                  2  %                  -  %





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                             Results of Operations

The following tables set forth our results of operations for the periods
presented and as a percentage of our total revenue for those periods. We have
included Zipwhip in our results of operations prospectively after July 14, 2021,
Twilio Segment after November 2, 2020; Twilio SendGrid after February 1, 2019,
and all other acquisitions from the respective closing dates of each such
acquisition. The period-to-period comparison of our historical results are not
necessarily indicative of the results that may be expected in the future.

Our results of operations may be significantly affected by many factors, such as
uncertainty regarding the impacts of the COVID-19 pandemic, fluctuations in
foreign exchange rates, changes in global economic conditions and customer
demand and spending, inflation, labor market constraints, world events and
existing and new domestic and foreign laws and regulations, as well as those
factors outlined in Part I, Item 1A, "Risk Factors."

Our revenue is primarily derived from usage-based fees we charge for certain of
our products, which can lead to variability and at times create significant
differences between forecasts and actual results. In addition, our product mix
and mix of international and domestic customers may significantly impact our
gross margin. Because usage trends by geographic region and by customer are
inherently difficult to estimate, our actual results could differ materially
from our estimates.


                                                                           Year Ended December 31,
                                                              2021                      2020                  2019
Consolidated Statements of Operations Data:                   (In thousands, except share and per share amounts)
Revenue                                               $        2,841,839          $   1,761,776          $  1,134,468
Cost of revenue (1) (2)                                        1,451,126                846,115               525,551
Gross profit                                                   1,390,713                915,661               608,917
Operating expenses:
Research and development (1) (2)                                 789,219                530,548               391,355
Sales and marketing (1) (2)                                    1,044,618                567,407               369,079
General and administrative (1) (2)                               472,460                310,607               218,268
Total operating expenses                                       2,306,297              1,408,562               978,702
Loss from operations                                            (915,584)              (492,901)             (369,785)
Other (expenses) income, net                                     (45,345)               (11,525)                7,569
Loss before benefit for income taxes                            (960,929)              (504,426)             (362,216)
Benefit for income taxes                                          11,029                 13,447                55,153

Net loss attributable to common


   stockholders                                       $         (949,900)         $    (490,979)         $   (307,063)
Net loss per share attributable to common
   stockholders, basic and diluted                    $            (5.45)         $       (3.35)         $      (2.36)
Weighted-average shares used in computing net
   loss per share attributable to common
   stockholders, basic and diluted                           174,180,465            146,708,663           130,083,046


____________________________________

(1) Includes stock-based compensation expense as follows:



                                                      Year Ended December 31,
                                                2021           2020           2019
                                                          (In thousands)
             Cost of revenue                 $  14,074      $   8,857      $   7,123
             Research and development          258,672        173,303        126,012
             Sales and marketing               213,351        103,450         60,886
             General and administrative        146,188         76,301         70,297
             Total                           $ 632,285      $ 361,911      $ 264,318

____________________________________

(2) Includes amortization of acquired intangibles as follows:


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                                                      Year Ended December 31,
                                                 2021           2020          2019
                                                          (In thousands)
              Cost of revenue                 $ 114,896      $ 59,501      $ 45,267
              Research and development            1,260             -             -
              Sales and marketing                82,493        38,915        27,540
              General and administrative            135            78             -
              Total                           $ 198,784      $ 98,494      $ 72,807


                                                                            Year Ended December 31,
                                                            2021                      2020                     2019
Consolidated Statements of Operations, as a
percentage of revenue: **
Revenue                                                          100  %                    100  %                   100  %
Cost of revenue                                                   51                        48                       46
Gross profit                                                      49                        52                       54
Operating expenses:
Research and development                                          28                        30                       34
Sales and marketing                                               37                        32                       33
General and administrative                                        17                        18                       19
Total operating expenses                                          81                        80                       86
Loss from operations                                             (32)                      (28)                     (33)
Other (expenses) income, net                                      (2)                       (1)                       1
Loss before benefit for income taxes                             (34)                      (29)                     (32)
Benefit for income taxes                                               *                     1                        5

Net loss attributable to common


   stockholders                                                  (33  %)                   (28  %)                  (27) %


____________________________________


* Less than 0.5% of revenue.
** Columns may not add up to 100% due to rounding.

     Comparison of the Fiscal Years Ended December 31, 2021, 2020 and 2019

Revenue

                                                  Year Ended December 31,
                                                                                                         2020 to 2021                      2019 to 2020
                                       2021                 2020                 2019                       Change                            Change
                                                                                    (Dollars in thousands)


Total Revenue                     $ 2,841,839          $ 1,761,776          $ 1,134,468          $ 1,080,063             61  %       $    627,308       55  %


2021 compared to 2020

In 2021, total revenue increased by $1.1 billion, or 61%, compared to the same
period last year. This increase was primarily attributable to an increase in the
usage of our products, particularly our Programmable Messaging products,
Programmable Voice products and Email products, the adoption of additional
products by our existing customers, the additional A2P fees imposed by certain
carriers and revenue contributions from our acquisitions of Twilio Segment,
Zipwhip and other businesses. The change in usage from our existing customers
was reflected in our Dollar­Based Net Expansion Rate of 131% for the year ended
December 31, 2021. The increase in usage was also attributable to a 16% increase
in the number of Active Customer Accounts, from 221,000 as of December 31, 2020,
to over 256,000 as of December 31, 2021.
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In 2021, U.S. revenue and international revenue represented $1.9 billion or 66%,
and $960.0 million, or 34%, respectively, of total revenue. In 2020, U.S.
revenue and international revenue represented $1.3 billion, or 73%, and $479.6
million, or 27%, respectively, of total revenue. The increase in international
revenue was attributable to the growth in usage of our products, particularly
our Programmable Messaging products and Programmable Voice products, by our
existing international Active Customer Accounts; a 14% increase in the number of
international Active Customer Accounts driven in part by our focus on expanding
our sales to customers outside of the United States; and revenue contribution
from our recent acquisitions.

2020 compared to 2019



In 2020, total revenue increased by $627.3 million, or 55%, compared to the same
period last year. This increase was primarily attributable to an increase in the
usage of our products, particularly our Programmable Messaging products and
Programmable Voice products, the adoption of additional products by our existing
customers, and revenue contribution from our acquisition of our Twilio Segment
business for the period from November 2, 2020, through December 31, 2020. This
increase was partially offset by pricing decreases that we have implemented over
time in the form of lower usage prices, in an effort to increase the reach and
scale of our platform. The changes in usage and prices in 2020 were reflected in
our Dollar­Based Net Expansion Rate of 137%. The increase in usage was also
attributable to a 23% increase in the number of Active Customer Accounts, from
179,000 as of December 31, 2019, to over 221,000 as of December 31, 2020, which
was also positively impacted by the customer accounts added through the
acquisition of our Twilio Segment business.

In 2020, U.S. revenue and international revenue represented $1.3 billion or 73%,
and $479.6 million, or 27%, respectively, of total revenue. In 2019, U.S.
revenue and international revenue represented $808.9 million, or 71%, and $325.6
million, or 29%, respectively, of total revenue. The increase in international
revenue was attributable to the growth in usage of our products, particularly
our Programmable Messaging products and Programmable Voice products, by our
existing international Active Customer Accounts; a 23% increase in the number of
international Active Customer Accounts driven in part by our focus on expanding
our sales to customers outside of the United States; and revenue contribution
from the acquisition of our Twilio Segment business.

Cost of Revenue and Gross Margin



                                                Year Ended December 31,
                                                                                                      2020 to 2021                      2019 to 2020
                                       2021                2020               2019                       Change                            Change
                                                 (Dollars in thousands)
Cost of revenue                   $ 1,451,126          $ 846,115          $ 525,551          $    605,011             72  %       $    320,564       61  %
Gross margin                               49  %              52  %              54  %


2021 compared to 2020

In 2021, cost of revenue increased by $605.0 million, or 72%, compared to the
same period last year. The increase in cost of revenue was primarily
attributable to a $465.5 million increase in network service providers' costs,
which included the additional A2P fees imposed by certain carriers, and a
$44.2 million increase in cloud infrastructure fees, all to support the growth
in usage of our products. The increase was also due to a $55.4 million increase
in the amortization expense of intangible assets that we acquired through
business combinations. In addition, the year ended December 31, 2021, included
cost of revenue from our recent acquisitions.

In 2021, the gross margin percentage declined compared to the same period last
year. This decline was primarily driven by continued strong growth of our
international messaging business, the additional A2P fees imposed by certain
carriers and an increase in network service provider fees in certain
geographies, which we pass to our customers at cost. The decline was also due to
an increase in amortization expense related to our acquired intangible assets,
These declines were partially offset by the growth of our other application
services products, the impact of the acquisition of our Twilio Segment business
and certain operational improvements.
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2020 compared to 2019



In 2020, cost of revenue increased by $320.6 million, or 61%, compared to the
same period last year. The increase in cost of revenue was primarily
attributable to a $246.2 million increase in network service providers' costs
and a $32.3 million increase in cloud infrastructure fees, both to support the
growth in usage of our products. The increase was also due to a $14.2 million
increase in the amortization expense of intangible assets that we acquired
through business combinations.

In 2020, gross margin percentage declined compared to the same period last year.
This decline was primarily driven by a re-acceleration in growth of our
messaging business, an increase in amortization expense related to acquired
intangible assets, the impact of an increasing mix of international product
usage and an increase in network service provider fees in certain geographies,
which we pass to our customers at cost. These declines were partially offset by
the impact of the acquisition of our Twilio Segment business and certain
operational improvements.

Operating Expenses

                                                        Year Ended December 31,
                                                                                                               2020 to 2021                      2019 to 2020
                                              2021                 2020                2019                       Change                            Change
                                                                                           (Dollars in thousands)
Research and development                 $   789,219          $   530,548          $ 391,355          $    258,671             49  %       $    139,193       36  %
Sales and marketing                        1,044,618              567,407            369,079               477,211             84  %            198,328       54  %
General and administrative                   472,460              310,607            218,268               161,853             52  %             92,339       42  %
Total operating expenses                 $ 2,306,297          $ 1,408,562          $ 978,702          $    897,735             64  %       $    429,860       44  %


2021 compared to 2020

In 2021, research and development expenses increased by $258.7 million, or 49%,
compared to the same period last year. The increase was primarily attributable
to a $225.0 million increase in personnel costs, net of a $15.7 million increase
in capitalized software development costs, largely as a result of a 54% average
increase in our research and development headcount, as we continued to focus on
enhancing our existing products, introducing new products as well as enhancing
product management and other technical functions. In addition, the year ended
December 31, 2021 included research and development expenses and the impact of
growth in headcount from our recent acquisitions.

In 2021, sales and marketing expenses increased by $477.2 million, or 84%,
compared to the same period last year. The increase was primarily attributable
to a $331.5 million increase in personnel costs, largely as a result of a 74%
average increase in sales and marketing headcount, as we continued to expand our
sales efforts globally. The increase was also due to a $43.6 million increase
related to the amortization of acquired intangible assets and a $31.6 million
increase in advertising expenses. In addition, the year ended December 31, 2021
included sales and marketing expenses and the impact of growth in headcount from
our recent acquisitions.

In 2021, general and administrative expenses increased by $161.9 million, or
52%, compared to the same period last year. The increase was primarily
attributable to a $142.1 million increase in personnel costs, largely as a
result of a 75% average increase in general and administrative headcount, to
support the growth of our business globally. The increase was also due to a
$12.2 million increase in charitable contributions that we made through
Twilio.org, $11.2 million increase in professional service fees incurred in the
ordinary course of business, offset by a $14.2 million decrease in professional
services related to our acquisitions. In addition, the year ended December 31,
2021 included general and administrative expenses and the impact of growth in
headcount from our recent acquisitions.

2020 compared to 2019



In 2020, research and development expenses increased by $139.2 million, or 36%,
compared to the same period last year. The increase was primarily attributable
to a $128.3 million increase in personnel costs, net of a $17.8 million increase
in capitalized software development costs, largely as a result of a 63% average
increase in our research and development headcount, as we continued to focus on
enhancing our existing products, introducing new products as well as enhancing
product management and other technical functions. The increase was also due to a
$13.3 million increase in our cloud infrastructure fees related to staging and
development of our products. In addition, the year ended December 31, 2020
included research and development expenses and headcount from our recent
acquisitions.
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In 2020, sales and marketing expenses increased by $198.3 million, or 54%,
compared to the same period last year. The increase was primarily attributable
to a $137.4 million increase in personnel costs, largely as a result of a 88%
average increase in sales and marketing headcount, as we continued to expand our
sales efforts in the United States and abroad. The increase was also due to a
$11.4 million increase related to the amortization of acquired intangible assets
and a $20.1 million increase in advertising expenses. In addition, the year
ended December 31, 2020, included sales and marketing expenses and headcount
from our recent acquisitions.

In 2020, general and administrative expenses increased by $92.3 million, or 42%,
compared to the same period last year. The increase was primarily attributable
to a $25.4 million increase in personnel costs, largely as a result of a 66%
average increase in general and administrative headcount, to support the growth
of our business globally. The increase was also due to a $19.0 million increase
in charitable contributions due to several donations made by Twilio.org, a $10.7
million increase in our allowance for estimated credit losses partially impacted
by the COVID-19 environment and a $5.8 million increase in professional expenses
related to our acquisitions of other business. Additionally, certain of our
taxes increased by $7.9 million primarily in foreign jurisdictions and our
professional services fees increased by $6.6 million. In addition, the year
ended December 31, 2021 included general and administrative expenses and
headcount from our recent acquisitions.

                        Liquidity and Capital Resources

Our principal sources of liquidity have been (i) the net proceeds of $979.0
million, $1.4 billion and $1.8 billion, net of underwriting discounts and
offering expenses paid by us, from our public equity offerings in June 2019,
August 2020 and February 2021, respectively; (ii) the aggregate net proceeds of
approximately $537.0 million, after deducting purchaser discounts and debt
issuance costs paid by us, from the issuance of our Convertible Notes in May
2018; (iii) the aggregate net proceeds of approximately $984.7 million, after
deducting purchaser discounts and debt issuance costs paid by us, from the
issuance of our 2029 Notes and 2031 Notes in March 2021; (iv) the net proceeds
of $228.4 million, after deducting transaction costs paid by us, from settlement
of our capped call arrangements in June 2021; and (v) the payments received from
customers using our products.

Our primary uses of cash include operating costs, such as personnel-related
costs, network service provider costs, cloud infrastructure costs,
facility-related spending, as well as acquisitions and investments. Refer to
Note 6, Note 10, Note 13(a) and Note 18 to our consolidated financial statements
included elsewhere in this Annual Report on Form 10-K for detailed discussions
of our obligations and commitments related to leases, debt, other purchase
obligations and our proposed minority investment in Syniverse Corporation.

We may, from time to time, consider acquisitions of, or investments in,
complementary businesses, products, services, capital infrastructure or
technologies which might affect our liquidity requirements, cause us to secure
additional financing or issue additional equity or debt securities. There can be
no assurance that additional credit lines or financing instruments will be
available in amounts or on terms acceptable to us, if at all.

We believe that our cash, cash equivalents and marketable securities balances,
as well as the cash flows generated by our operations, will be sufficient to
satisfy our anticipated cash needs for working capital and capital expenditures
for the next 12 months and beyond. However, our belief may prove to be
incorrect, and we could utilize our available financial resources sooner than we
currently expect. Our future capital requirements and the adequacy of available
funds will depend on many factors, including those set forth in Part I, Item 1A,
"Risk Factors." We may be required to seek additional equity or debt financing
in order to meet these future capital requirements. In the event that additional
financing is required from outside sources, we may not be able to raise it on
terms acceptable to us, or at all. If we are unable to raise additional capital
when desired, our business, results of operations and financial condition would
be adversely affected. Additionally, cash from operations could also be affected
by various risks and uncertainties in connection with the COVID-19 pandemic,
including timing and ability to collect payments from our customers and other
risks detailed in Part I, Item 1A, "Risk Factors."

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Cash Flows

The following table summarizes our cash flows:



                                                                              Year Ended December 31,
                                                                   2021                 2020                 2019
                                                                                   (In thousands)
Cash (used in) provided by operating activities               $    (58,192)         $   32,654          $    14,048
Cash (used in) investing activities                             (2,489,996)           (845,855)          (1,285,792)
Cash provided by financing activities                            3,096,325           1,493,311            1,020,145
Effect of exchange rate changes on cash, cash
equivalents and restricted cash                                       (191)                 40                    -

Net increase (decrease) in cash, cash equivalents and restricted cash

$    547,946

$ 680,150 $ (251,599)

Cash Flows from Operating Activities



In 2021, cash used in operating activities consisted primarily of our net loss
of $949.9 million adjusted for non-cash items, including $632.3 million of
stock-based compensation expense, $17.2 million of tax benefit related to
release of valuation allowance in connection with our Zipwhip and prior
acquisitions, $258.4 million of depreciation and amortization expense, $5.8
million amortization of the debt discount and issuance costs related to our
long-term debt, $48.8 million of non-cash reduction to our operating
right-of-use asset, $31.5 million amortization of deferred commissions and
$185.1 million of cumulative changes in operating assets and liabilities. With
respect to changes in operating assets and liabilities, accounts receivable and
prepaid expenses increased $196.0 million primarily due to revenue growth, the
timing of cash receipts and pre-payments for cloud infrastructure fees and
certain operating expenses. Accounts payable and other current liabilities
increased $137.7 million primarily due to increases in transaction volumes.
Operating lease liability decreased $49.0 million due to payments made against
our operating lease obligations. Other long-term assets increased $121.2 million
primarily due to an increase in the sales commissions balances related to the
growth of our business.

In 2020, cash provided by operating activities consisted primarily of our net
loss of $491.0 million adjusted for non-cash items, including $360.9 million of
stock-based compensation expense, $16.5 million of tax benefit related to
release of valuation allowance in connection with our acquisitions of other
businesses, $149.7 million of depreciation and amortization expense, $23.8
million amortization of the debt discount and issuance costs related to our
long-term debt, $38.4 million of non-cash reduction to our operating
right-of-use asset, $13.3 million amortization of deferred commissions, a $13.2
million increase in our allowance for credit losses, and $97.4 million of
cumulative changes in operating assets and liabilities. With respect to changes
in operating assets and liabilities, accounts receivable and prepaid expenses
increased $92.9 million primarily due to the timing of cash receipts from
certain of our larger customers, pre-payments for cloud infrastructure fees and
certain operating expenses. Accounts payable and other current liabilities
increased $98.4 million primarily due to increases in transaction volumes.
Operating lease liability decreased $33.9 million due to payments made against
our operating lease obligations. Other long-term assets increased $81.9 million
primarily due to an increase in the sales commissions balances related to the
growth of our business.

Cash Flows from Investing Activities



In 2021, cash used in investing activities was $2.5 billion primarily consisting
of $1.9 billion of purchases of marketable securities and other investments, net
of maturities and sales, $491.5 million of net cash paid to acquire other
businesses as described in Note 7 to our consolidated financial statements
included elsewhere in this Annual Report on Form 10-K, $44.0 million related to
capitalized software development costs and $46.0 million related to purchases of
long-lived assets.

In 2020, cash used in investing activities was $845.9 million primarily
consisting of $453.1 million of purchases of marketable securities and other
investments, net of maturities and sales, $333.6 million of net cash paid to
acquire other businesses as described in Note 7 to our consolidated financial
statements included elsewhere in this Annual Report on Form 10-K, $33.3 million
related to capitalized software development costs and $25.8 million related to
purchases of long-lived assets.
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Cash Flows from Financing Activities



In 2021, cash provided by financing activities was $3.1 billion primarily
consisting of $1.8 billion in net proceeds from our public equity offering, as
described in Note 14 to our consolidated financial statements included elsewhere
in this Annual Report on Form 10-K; $984.7 million in net proceeds from the
issuance of our 2029 Notes and 2031 Notes and $228.4 million in net proceeds
from the settlement of the capped call transactions related to our Convertible
Notes, which were fully redeemed during 2021, as described in Note 10 to our
consolidated financial statements included elsewhere in this Annual Report on
Form 10-K; and $136.2 million in proceeds from stock options exercised by our
employees and shares issued under our employee stock purchase plan.

In 2020, cash provided by financing activities was $1.5 billion primarily
consisting of $1.4 billion in net proceeds from our public equity offering, as
described in Note 14 to our consolidated financial statements included elsewhere
in this Annual Report on Form 10-K, and $104.8 million in proceeds from stock
options exercised by our employees and shares issued under our employee stock
purchase plan.

                         Off-Balance Sheet Arrangements

We have not entered into any off-balance sheet arrangements and do not have any holdings in variable interest entities.


                              Segment Information

We have one business activity and operate in one reportable segment.


                   Critical Accounting Policies and Estimates

Our consolidated financial statements are prepared in accordance with generally
accepted accounting principles in the United States of America. The preparation
of these consolidated financial statements requires us to make estimates and
assumptions that affect the reported amounts of assets, liabilities, revenue,
expenses and related disclosures. We evaluate our estimates and assumptions on
an ongoing basis. Our estimates are based on historical experience and various
other assumptions that we believe to be reasonable under the circumstances. Our
actual results could differ from these estimates.

We believe that the accounting policies, assumptions and estimates associated
with revenue recognition and business combinations have the greatest potential
impact on our consolidated financial statements. Therefore, we consider these to
be our critical accounting policies and estimates.

See Note 2 to the consolidated financial statements included elsewhere in this Annual Report on Form 10-K for a discussion of our accounting policies.

Revenue Recognition



Revenue is recognized upon transfer of control of promised products or services
to customers in an amount that reflects the consideration we expect to receive
in exchange for those products or services. We enter into contracts that can
include various combinations of products and services, which are generally
capable of being distinct and accounted for as separate performance obligations.
Revenue is recognized net of allowances for credits and any taxes collected from
customers, which are subsequently remitted to governmental authorities.

Our revenue is primarily derived from usage-based fees earned from customers
accessing our enterprise cloud computing services. Platform access is considered
a monthly series comprising one performance obligation and usage-based fees are
recognized as revenue in the period in which the usage occurs.

Subscription-based fees are derived from certain non-usage-based contracts, such
as with the sales of short codes, customer support, and fees charged to access
the cloud-based platform of our Twilio Segment business, which acquisition is
further described in Note 7 to our consolidated financial statements included
elsewhere in this Annual Report of Form 10-K. Non-usage-based contracts revenue
is recognized on a ratable basis over the contractual term which is generally
from one to three years.
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Our arrangements do not contain general rights of return. However, credits may
be issued on a case-by-case basis. Credits are accounted for as variable
consideration, are estimated based on historical trends and are recorded against
revenue. The contracts do not provide customers with the right to take
possession of the software supporting the applications. Amounts that have been
invoiced are recorded in accounts receivable and in revenue or deferred revenue
depending on whether the revenue recognition criteria have been met.

Business Combinations



Accounting for business combinations requires us to make significant estimates
and assumptions, especially at the acquisition date with respect to tangible and
intangible assets acquired and liabilities assumed. We use our best estimates
and assumptions to accurately assign fair value to the tangible and intangible
assets acquired and liabilities assumed at the acquisition date as well as the
useful lives of those acquired intangible assets. Examples of critical estimates
in valuing certain of the intangible assets and goodwill we have acquired
include but are not limited to future expected cash flows from acquired
developed technologies; existing customer relationships; uncertain tax positions
and tax related valuation allowances assumed; and discount rates. Unanticipated
events and circumstances may occur that may affect the accuracy or validity of
such assumptions, estimates or actual results.

                Recent Accounting Pronouncements Not Yet Adopted

See Note 2(ac) to the consolidated financial statements included elsewhere in this Annual Report on Form 10-K for a discussion of recent accounting pronouncements not yet adopted.

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