Item 2.02 Results of Operations and Financial Condition.

On May 4, 2022, Twilio Inc. (the "Company") issued a press release announcing its financial results for the quarterly period ended March 31, 2022. A copy of the press release is furnished herewith as Exhibit 99.1.

The information furnished under this Item 2.02 and in the accompanying Exhibit 99.1 shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act regardless of any general incorporation language in such filing, unless expressly incorporated by specific reference in such filing.

Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

(b) On April 28, 2022, Elena Donio, informed the Company of her intention to resign from the Company's board of directors (the "Board") and the Company's Compensation and Talent Management Committee. The Board accepted Ms. Donio's resignation on April 29, 2022. Ms. Donio's resignation did not result from any disagreements with the Company on any matter relating to its operations, policies or practices. Effective as of the time of Ms. Donio's resignation on April 29, 2022, the Board reduced the size of the Board to eight members. The Company thanks Ms. Donio for her years of service as a member of the Board and Compensation and Talent Management Committee and looks forward to her contributions in her role as the Company's President of Revenue. On April 28, 2022, Marc D. Boroditsky notified the Company of his intention to resign from his position as the Chief Revenue Officer of the Company effective immediately. His last day of employment will be August 19, 2022. Mr. Boroditsky's current salary, benefits and stock option and restricted stock unit award vesting schedules will remain in effect until August 19, 2022, subject to his continued employment through such date.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits.

Exhibit No. Description

99.1 Press release issued by Twilio Inc. dated May 4 , 2022

104 Cover Page Interactive Data File (embedded within the Inline XBRL document)

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