Valbiotis SA announced that it has completed the recruitment of 600 volunteers for the international multicenter Phase II/III REVERSE-IT clinical study on TOTUM•63. This randomized, placebo-controlled study evaluates the efficacy of TOTUM•63, a plant-based active substance, in a population with impaired glucose metabolism, from prediabetes to untreated type 2 diabetes (early stage). The primary objective will be the reduction of fasting blood glucose levels after 24 weeks of TOTUM•63 supplementation compared to placebo.

The results will be communicated at the end of the study. The Phase II/III REVERSE-IT study was co-designed by the Valbiotis and Nestlé Health Science medical and regulatory teams to demonstrate the efficacy of TOTUM•63 against prediabetes and untreated type 2 diabetes (early stage), as part of the global strategic partnership between the two companies. REVERSE-IT should confirm the positive results of the Phase II clinical study already obtained in a similar population with TOTUM•63.