Item 5.02. Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

On March 24, 2021, Vaxcyte, Inc. (the "Company") was made aware of allegations of sexual harassment and inappropriate conduct towards an employee of GlaxoSmithKline plc ("GSK") by Moncef Slaoui, Ph.D., the Chairman of the Company's Board of Directors (the "Board"), which occurred when he was an employee of GSK.

Based on these allegations and in alignment with Vaxcyte's corporate values and policies, the Board has requested Dr. Slaoui's resignation. Dr. Slaoui has agreed and has resigned from the Board effective immediately.

Dr. Slaoui joined the Board in July 2017 and became Chairman of the Board in May 2018. Dr. Slaoui also served on the Compensation Committee. Dr. Slaoui's resignation was not the result of any dispute or disagreement with the Company or the Company's Board on any matter relating to the operations, policies or practices of the Company.

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