Xbrane Biopharma AB (publ) has been granted two new patents by the Swedish patent and Registration Office (PRV). The patents relate to novel methods of using signal peptides to enhance the production yield and thereby lowering the production cost of recombinant proteins expressed in E.coli. The patents are an important additional component to Xbrane's platform technology aimed at enabling development of biosimilar candidates to the lowest production cost possible. Recombinant proteins are produced via the introduction of a DNA-sequence into a living cell instructing it to produce the protein of interest. Signal peptides typically function to prompt a cell to translocate the recombinant protein, usually through and across the cellular membrane. It has been demonstrated in the patents that certain nucleic acid sequences of the DNA sequences encoding the signal peptides positively impact the production yield, i.e., the amount of the targeted recombinant protein produced at a given scale of fermentation. The patents relate to specific such novel nucleic acid sequences encoding various signal peptides that have been demonstrated to have significant impact on production yield.