“The treatment of CML has been revolutionized by tyrosine kinase inhibitors (TKI), but many patients are still not receiving their full clinical benefit. Our data suggest that the amorphous solid dispersion formulation of dasatinib - XS004, produced with HyNap technology, have the potential to reduce variability in drug exposure and unleash the full therapeutic power of TKI for more patients. We are pleased with the opportunity to present our findings for XS004 to the international CML community at ASH, the world´s largest and leading conference venue in hematology”, says
Xspray in collaboration with researchers from Uppsala University &
“The concomitant use of TKIs and acid-reducing agents is widespread in CML. By reducing the pH sensitivity of TKIs we believe this can assist more patients to benefit from the treatment,” says Per Andersson, CEO of
The 2 posters are available for download:
- Comedication of Proton Pump Inhibitors and Dasatinib Is Common in CML but XS004, a Novel Amorphous Solid Dispersion Formulation of Dasatinib, Provides Improved Uptake and Low pH-Dependency, Minimizing Unwanted Drug-Drug Interactions
- XS004 Dasatinib (XS004) Improves Variability and Bioavailability in Humans Using Amorphous Solid Dispersion Formulation of Dasatinib with Potential Implications for Its Clinical Use
“I believe these results are an important step forward in addressing real-world challenges associated with crystalline TKIs,” said Dr
The
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