Crescendo Biologics Ltd. (Crescendo) announced that Zai Lab has reported positive topline results from a randomized, double-blind, placebo-controlled Phase 1b proof-of-concept study of ZL-1102, an anti-IL-17A targeting Humabody?. The Phase 1b trial was a first-in-human study to evaluate the safety, pharmacokinetics and efficacy of a topical formulation of ZL-1102 in adults with mild-to-moderate chronic plaque psoriasis (CPP). The study recruited 53 patients with CPP, and it is reported that topical therapy with ZL-1102 resulted in clinical improvement in local PASI score, erythema and scaling, target lesion size and responder rates, and that a consistent improvement in patients was seen over time. The safety profile of ZL-1102 was comparable to placebo. The declaration of clinical proof-of-concept for ZL-1102 by Zai Lab triggers a milestone payment from Zai Lab to Crescendo under the terms of the exclusive worldwide license agreement for ZL-1102 (formerly CB001) announced in May 2018. Under the terms of that agreement, Crescendo granted to Zai Lab a worldwide exclusive license to develop and commercialize ZL-1102 for all indications. Zai Lab is responsible for conducting all regulatory filings, clinical studies and commercialization activities, with Crescendo being eligible for certain development, regulatory, and commercial milestones as well as tiered royalties on global sales.