ITEM 7.01 REGULATION FD DISCLOSURE

On May 27, 2022, Zymeworks Inc. ("Zymeworks") issued a press release announcing that management will participate in an upcoming investor conference:

Jefferies Healthcare Conference. Zymeworks will participate in one-on-one
          meetings on June 8th - 9th and will present on June 8th at 9:30 a.m. ET
          in New York, NY.

On May 27, 2022, Zymeworks filed this press release with the Canadian securities regulatory authorities on the System for Electronic Document Analysis and Retrieval ("SEDAR") at www.sedar.com.

A copy of this press release is attached as Exhibit 99.1 hereto.

The information provided under this Item (including Exhibit 99.1, attached hereto) shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934 (the "Exchange Act") or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such a filing.

ITEM 9.01 FINANCIAL STATEMENTS AND EXHIBITS





  (d) Exhibits



Exhibit
  No.     Description

99.1        Press Release dated May 27, 2022.

104       Cover Page Interactive Data File (embedded as Inline XBRL document).

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