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Company	Sector	Price	Change	5-day change	1st Jan %	Capi. (M$)
ORTOMA AB ^USD	Medical Software & Technology Servi...	7.4854	256.65%	0.00%	184.87%	118
FLAGSHIP GLOBAL CORP ^USD	Medical Diagnostic & Testing Equipm...	1.09	96.40%	0.00%	0.00%	172
ALDER BIOPHARMACEUTICALS INC ^USD	Bio Therapeutic Drugs	18.5	83.90%	15.77%	-1.85%	841
IDEAYA BIOSCIENCES INC ^USD	Biotechnology & Medical Research - ...	9.79	25.67%	37.89%	0.00%	158
CELL MEDX CORP ^USD	Bio Therapeutic Drugs	1.49	24.17%	45.45%	990.91%	67
NOVAVAX, INC. ^USD	Biotechnology & Medical Research - ...	7.57	19.78%	39.15%	-79.43%	151
INTEGRITY APPLICATIONS INC ^USD	Bio Diagnostics & Testing	0.5	19.05%	0.00%	-16.00%	68
KODIAK SCIENCES INC ^USD	Bio Therapeutic Drugs	17.57	17.21%	46.42%	147.46%	553
LEXICON PHARMACEUTICALS, INC. ^USD	Bio Therapeutic Drugs	2.74	17.09%	92.96%	-58.73%	249
AMPLITUDE SURGICAL ^EUR	Medical Equipment, Supplies & Distr...	1.515	16.54%	18.82%	-44.91%	69
ELBIT MEDICAL TECHNOLOGIES LTD ^ILa	Medical Imaging Systems	87.6	16.49%	1.62%	-21.01%	51
GULF MEDICAL PROJECTS COMPANY PS.. ^AED	Healthcare Facilities & Services - ...	1.49	14.62%	14.62%	-14.86%	284
WAVE LIFE SCIENCES LTD ^USD	Biotechnology & Medical Research - ...	27.4	14.45%	30.79%	-34.82%	821
CHAMPIONS ONCOLOGY INC ^USD	Biotechnology & Medical Research - ...	6.9	14.05%	15.00%	-11.65%	70
COMMON SPLENDOR INTL HLTH INDSTR.. ^HKD	Healthcare Facilities & Services - ...	0.57	14.00%	14.00%	-10.94%	192
AVADEL PHARMACEUTICALS PLC (ADR) ^USD	Pharmaceuticals - NEC	2.46	13.89%	11.82%	-4.65%	81
ANAVEX LIFE SCIENCES CORP ^USD	Bio Therapeutic Drugs	3.32	13.70%	18.15%	112.82%	154
CEL-SCI CORPORATION ^USD	Bio Therapeutic Drugs	9.12	13.01%	6.32%	181.18%	283
NAMASTE TECHNOLOGIES INC ^CAD	Alternative Medicine	0.55	12.24%	-27.94%	-38.75%	119
CHEMESIS INTERNATIONAL INC ^CAD	Alternative Medicine	0.94	11.90%	-7.69%	-14.29%	69
PULSE BIOSCIENCES INC ^USD	Advanced Medical Equipment & Techno...	16.18	11.66%	23.32%	41.19%	301
PANACEA BIOTEC LTD ^INR	Generic Pharmaceuticals	152.65	10.82%	10.90%	-4.11%	132
SIRONA BIOCHEM CORP ^CAD	Biotechnology & Medical Research - ...	0.475	10.47%	-8.51%	405.88%	71
ALPINE IMMUNE SCIENCES INC ^USD	Bio Therapeutic Drugs	4.24	10.42%	-9.79%	15.22%	71
CYCLERION THERAPEUTICS INC ^USD	Biotechnology & Medical Research - ...	12.3	10.41%	17.70%	0.00%	305
GENESIS HEALTHCARE INC ^USD	Residential & Long Term Care	1.41	10.16%	19.49%	19.49%	138
PORTAGE BIOTECH INC ^USD	Biotechnology & Medical Research - ...	0.1	9.89%	-16.67%	4.17%	99
VTV THERAPEUTICS INC ^USD	Bio Therapeutic Drugs	1.77	9.60%	19.11%	-39.06%	54
SPECTRUM PHARMACEUTICALS, INC. ^USD	Biotechnology & Medical Research - ...	9.7	9.48%	27.80%	10.86%	984
ADVERUM BIOTECHNOLOGIES INC ^USD	Bio Therapeutic Drugs	6.29	8.82%	-49.48%	99.68%	373
ACADIA PHARMACEUTICALS INC. ^USD	Biotechnology & Medical Research - ...	44.01	8.80%	13.28%	172.17%	5 845
NEXT SCIENCE LTD ^AUD	Pharmaceuticals - NEC	3.1	8.77%	0.35%	0.00%	352
OPTINOSE INC ^USD	Biotechnology & Medical Research - ...	7.8	8.64%	14.20%	25.81%	298
AXSOME THERAPEUTICS INC ^USD	Bio Therapeutic Drugs	29.16	8.64%	20.45%	934.04%	924
ENDO INTERNATIONAL PLC ^USD	Generic Pharmaceuticals	4.2	8.25%	36.81%	-42.47%	878
SURFACE ONCOLOGY INC ^USD	Bio Therapeutic Drugs	2.24	8.21%	21.08%	-47.17%	58
PCI BIOTECH HOLDING ASA ^NOK	Bio Therapeutic Drugs	30.45	8.17%	4.26%	7.03%	117
SEQUENT SCIENTIFIC LTD ^INR	Pharmaceuticals - NEC	83.85	8.12%	8.90%	23.31%	287
ADVANCED MEDICAL SOLUTIONS GROUP.. ^GBp	Medical Supplies	244	7.96%	-16.44%	-11.27%	604
AERIE PHARMACEUTICALS INC ^USD	Bio Therapeutic Drugs	23.84	7.92%	16.46%	-33.96%	1 015
THERAPEUTICSMD INC ^USD	Specialty & Advanced Pharmaceutical...	3.69	7.89%	19.42%	-3.15%	825
RUBIUS THERAPEUTICS INC ^USD	Bio Therapeutic Drugs	10.27	7.77%	8.22%	-36.13%	759
GOSSAMER BIO INC ^USD	Biotechnology & Medical Research - ...	21.38	7.71%	7.33%	0.00%	1 309
KARYOPHARM THERAPEUTICS INC ^USD	Bio Therapeutic Drugs	11.85	7.43%	22.29%	26.47%	683
AVALON GLOBOCARE CORP ^USD	Biotechnology & Medical Research - ...	2.47	7.39%	14.62%	-10.18%	174
SMS PHARMACEUTICALS LTD ^INR	Generic Pharmaceuticals	50.05	7.17%	11.47%	-26.61%	60
AC IMMUNE SA ^USD	Biotechnology & Medical Research - ...	5.41	7.13%	2.27%	-42.75%	341
SHOCKWAVE MEDICAL INC ^USD	Medical Equipment	32.85	7.11%	-5.36%	0.00%	860
EQUILLIUM INC ^USD	Pharmaceuticals - NEC	4.08	7.09%	10.27%	-50.00%	66
PARADIGM BIOPHARMACEUTICALS LTD ^AUD	Biopharmaceuticals	2.13	7.04%	2.05%	94.11%	263

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