GT Biopharma, Inc. a clinical stage immuno-oncology company focused on developing innovative therapeutics based on the Company's proprietary natural killer cell engager, TriKE protein biologic technology platform, announced that Jeffrey Miller, MD, University of Minnesota Medical School, Professor of Medicine, Division of Hematology, Oncology and Transportation will present a mini-oral presentation at the European Society for Medical Oncology Congress 2021 to be held virtually September 16-21. The mini-oral presentation will present updated positive Phase 1 safety data, progress, and preclinical data going beyond hematologic malignancies to solid tumors of a Phase 1 GTB-3550 TriKE trial. The Tri-Specific Killer Engager TriKE program is currently in pre-clinical and clinical development for the treatment of relapsed/refractory acute myelogenous leukemia and high-risk myelodysplastic syndrome with solid tumor TriKE commercial manufacturing and IND enabling studies in progress. Therapeutic and commercial advantages of GTB-3650 compared to GTB-3550 include: Based on second generation camelid single-domain antibody technology that holds several advantages over traditional IgG monoclonal antibodies; Improved potency and enhanced binding affinity; Similar preclinical safety profile; Commercial manufacturing capabilities through arrangement with Cytovance; Proprietary patented molecule, which unlike GTB-3550, is wholly owned by GT Biopharma; Camelid antibodies are single domain antibodies from the Camelidae family of mammals that include llamas, camels, and alpacas. These animals produce 2 main types of antibodies. One type of antibody camelids produce is the conventional antibody that is made up of 2 heavy chains and 2 light chains. They also produce another type of antibody that is made up of only 2 heavy chains and no light chain. This is known as heavy chain IgG. While these antibodies do not contain the CH1 region, they retain an antigen binding domain called the VHH region. VHH antibodies, also known as single domain antibodies, contain only the VHH region from the camelid antibody. Camelid antibodies have key characteristics, which include high affinity and specificity, high thermostability, good solubility and strictly monomeric behavior, small size, relatively low production cost, ease of genetic engineering, format flexibility or modularity, low immunogenicity, and a higher penetration rate into tissues. GTB-3650 is the Company's lead second-generation Tri-Specific Killer Engager TriKE program currently in preclinical development for the treatment of relapsed/refractory acute myelogenous leukemia and high-risk myelodysplastic syndrome.