"If the Greeks will vote 'no', the Greek position is dramatically weakened," Juncker told a news conference launching Luxembourg's six-month presidency of the European Union.

"The program has come to an end, there are no negotiations under way, if the Greeks will vote no, they have done everything but strengthening the Greek negotiation position," he added.

"Even in the case of a 'yes' vote, we'll have to face difficult negotiations," Juncker said.

Luxembourg Prime Minister Xavier Bettel said the EU needed to build bridges with Greece and with Britain, which plans a referendum on EU membership.

(Reporting by Michele Sinner, writing by Adrian Croft; editing by Foo Yun Chee; editing by Robert-Jan Bartunek)