Corporate Overview

July 2022

©SPARC

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Pipeline overview & key short-term catalysts

Asset / Program

MoA

Indication

Discovery Preclinical Phase 1

Phase 2

Phase 3/

Upcoming

Partner

Registration Study

Catalyst

Parkinson's

PoC data from

PROSEEK

Disease

study in 2023

Vodobatinib

c-ABL

Lewy Body

PoC data in 2023

(SCC-138)

Inhibitor

Dementia1

Alzheimer's

Disease

Vodobatinib

BCR-ABL

Refractory

Pivotal data

(SCO-088)

Inhibitor

CML

in 2024

SCO-120

SERD

Metastatic

Phase 1 data

Breast Cancer

in 2023

Psoriasis

Phase 2

Vibozilimod

Selective

data in 2023

(SCD-044)

S1PR1 agonist

Atopic

Phase 2 data

Dermatitis

in 2023

Alopecia

Areata

ADC

MUC-1

Multiple

IND Filing

Tumors

Targeted 2023

Delivery Systems programs | Commercial (2 in Ophthalmology and 1 in Neurology).

Assets - Elepsia XR, Xelpros BAK Free, Lipodox and other platform licensing trxns + 3 NDAs planned for 2022 Preclinical Assets | 10+ preclinical assets under development to ensure a robust pipeline for future growth

Neurology Oncology Immunology

1. Investigator Initiated Study | MoA = Mechanism of Action | PoC = Proof of Concept | CML = Chronic Myeloid Leukemia | SERD = Selective Estrogen Receptor Degrader | S1PR1 = Sphingosine-1-Phosphate Receptor 1 IND = Investigational New Drug | TAA-1 = Tumor Associated Antigen-1 | IBD = Inflammatory Bowel Disease

SPARC © 2022

3

Long term intent - Realize the potential of SPARC operating model to build a high impact institution

Access early stage science and capabilities globally

Calibrated risk taking in large

unmet needs

Collaborations with academic innovators and small biotechs

Competitive partnering model

Growing footprint

Robust internal validation and stage gates

Focused internal ideation effort

Efficient translation leveraging cost and patient access advantages

Low cost of failure/

More shots on the goal

Strong Med-Chem team & growing Biologics group focusing on multi-specific conjugates & fusions Biology infrastructure and CMC expertise to validate developability and progress to clinic

Network of service providers Experienced clinical team with an India/US focus

Maximize value capture

through 'asset appropriate'

commercialization

Strategic flexibility to

maximize returns

Leverage legacy portfolio for non-dilutive capital through licensing transactions Maintain optionality on high value assets

Asset specific vehicles to continue to develop assets without diluting SPARC Maintain flexibility for the SPV exits

Extent of validation

Where do we go

Feed the beast - Good science in identified problems | Focus on early target validation | Early stage asset acquisitions & partnerships

Structure guided computational chemistry| modular biologics platform | Fully leverage & expand patient access advantages

Develop Vodobatinib & MUC-1 program into high value commercial propositions through non-dilutive structures post P2

SPARC © 2022

4

Opportunity to further extend the operating model advantages

SPARC strategic development partnerships

Expand the pre-clinical portfolio through targeted partnerships and asset acquisitions in key focus areas

SPARC operational footprint

Princeton, NJ

Clinical

Development,

Regulatory Sciences and

Partnerships

Currently 25 scientists.

Vadodara, India

3 centers, Discovery and Translational Dev Hub. Currently 225 scientists.

Mumbai, India

Houses Clinical Development and Delivery System Currently 150 scientists.

Internalization of clinical development operations Increase the patient capture from India

Create an Eastern European clinical execution hub to further expand the patient access advantage

Start building out late stage development capability

Fourth lab location with access to early stage biology & tax advantages for asset holding

SPARC commercial partnerships (Sun Pharma, CMS, Visiox, Tripoint)

Build the capital base to maintain optionality going into 2023 Start developing a commercial core for the future

SPARC © 2022

5

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Sun Pharma Advanced Research Company Limited published this content on 08 July 2022 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 08 July 2022 12:23:01 UTC.