Corporate Overview
July 2022
©SPARC
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SPARC © 2022 | 2 |
Pipeline overview & key short-term catalysts
Asset / Program | MoA | Indication | Discovery Preclinical Phase 1 | Phase 2 | Phase 3/ | Upcoming | Partner | ||
Registration Study | Catalyst | ||||||||
Parkinson's | PoC data from | ||||||||
PROSEEK | |||||||||
Disease | |||||||||
study in 2023 | |||||||||
Vodobatinib | c-ABL | Lewy Body | PoC data in 2023 | ||||||
(SCC-138) | Inhibitor | Dementia1 | |||||||
Alzheimer's | |||||||||
Disease | |||||||||
Vodobatinib | BCR-ABL | Refractory | Pivotal data | ||||||
(SCO-088) | Inhibitor | CML | in 2024 | ||||||
SCO-120 | SERD | Metastatic | Phase 1 data | ||||||
Breast Cancer | in 2023 | ||||||||
Psoriasis | Phase 2 | ||||||||
Vibozilimod | Selective | data in 2023 | |||||||
(SCD-044) | S1PR1 agonist | Atopic | Phase 2 data | ||||||
Dermatitis | in 2023 | ||||||||
Alopecia | |||||||||
Areata | |||||||||
ADC | MUC-1 | Multiple | IND Filing | ||||||
Tumors | Targeted 2023 | ||||||||
Delivery Systems programs | Commercial (2 in Ophthalmology and 1 in Neurology).
Assets - Elepsia XR, Xelpros BAK Free, Lipodox and other platform licensing trxns + 3 NDAs planned for 2022 Preclinical Assets | 10+ preclinical assets under development to ensure a robust pipeline for future growth
Neurology Oncology Immunology
1. Investigator Initiated Study | MoA = Mechanism of Action | PoC = Proof of Concept | CML = Chronic Myeloid Leukemia | SERD = Selective Estrogen Receptor Degrader | S1PR1 = Sphingosine-1-Phosphate Receptor 1 IND = Investigational New Drug | TAA-1 = Tumor Associated Antigen-1 | IBD = Inflammatory Bowel Disease
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Long term intent - Realize the potential of SPARC operating model to build a high impact institution
Access early stage science and capabilities globally
Calibrated risk taking in large
unmet needs
Collaborations with academic innovators and small biotechs
Competitive partnering model
Growing footprint
Robust internal validation and stage gates
Focused internal ideation effort
Efficient translation leveraging cost and patient access advantages
Low cost of failure/
More shots on the goal
Strong Med-Chem team & growing Biologics group focusing on multi-specific conjugates & fusions Biology infrastructure and CMC expertise to validate developability and progress to clinic
Network of service providers Experienced clinical team with an India/US focus
Maximize value capture
through 'asset appropriate'
commercialization
Strategic flexibility to
maximize returns
Leverage legacy portfolio for non-dilutive capital through licensing transactions Maintain optionality on high value assets
Asset specific vehicles to continue to develop assets without diluting SPARC Maintain flexibility for the SPV exits
Extent of validation
Where do we go
Feed the beast - Good science in identified problems | Focus on early target validation | Early stage asset acquisitions & partnerships
Structure guided computational chemistry| modular biologics platform | Fully leverage & expand patient access advantages
Develop Vodobatinib & MUC-1 program into high value commercial propositions through non-dilutive structures post P2
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Opportunity to further extend the operating model advantages
SPARC strategic development partnerships
Expand the pre-clinical portfolio through targeted partnerships and asset acquisitions in key focus areas
SPARC operational footprint
Princeton, NJ
Clinical
Development,
Regulatory Sciences and
Partnerships
Currently 25 scientists.
Vadodara, India
3 centers, Discovery and Translational Dev Hub. Currently 225 scientists.
Mumbai, India
Houses Clinical Development and Delivery System Currently 150 scientists.
Internalization of clinical development operations Increase the patient capture from India
Create an Eastern European clinical execution hub to further expand the patient access advantage
Start building out late stage development capability
Fourth lab location with access to early stage biology & tax advantages for asset holding
SPARC commercial partnerships (Sun Pharma, CMS, Visiox, Tripoint)
Build the capital base to maintain optionality going into 2023 Start developing a commercial core for the future
SPARC © 2022 | 5 |
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Sun Pharma Advanced Research Company Limited published this content on 08 July 2022 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 08 July 2022 12:23:01 UTC.